Saratov JOURNAL of Medical and Scientific Research

Tolstokorov A.S.

Saratov State Medical University

Comparative analysis of the quality of life before and after various methods of invasive treatment of esophageal cancer

Year: 2018, volume 14 Issue: №3 Pages: 408-411
Heading: Surgery Article type: Original article
Authors: Tolstokorov A.S., Ramazanov E.N., Dergunova S.A.
Organization: Saratov State Medical University
Summary:

The aim of the work is to assess the quality of life before and after multistage and one-stage operations, palliative interventions performed with malignant neoplasms of the esophagus. Material and Methods. The quality of life was evaluated in 565 patients with esophageal cancer at various stages of surgical treatment by means of questionnaires for assessing the quality of life of GIQLI, GSRS, MOS SF-36 questionnaire. Results. When performing multi-stage operations before the end of treatment, the quality of life changes insignificantly, and is comparable with the quality of life after palliative operations. The study of the quality of life after the end of treatment with the use of endoscopic minimally invasive technologies in these questionnaires convincingly showed the advantage of this category of surgical interventions due to less trauma, better cosmetic effect, quick activation and rehabilitation in the postoperative period. Conclusion. Taking into account the results of the research, preference is given to one-stage operations with the use of minimally invasive endoscopic techniques, which in a short time can save the patient from cancer and significantly improve the quality of life.

AttachmentSize
2018_3_408-411.pdf302.47 KB

Efficacy of surgical treatment of renal form of hyperparathyroidism

Year: 2018, volume 14 Issue: №2 Pages: 265-267
Heading: Surgery Article type: Original article
Authors: Kovalenko Yu.V., Tolstokorov A.S., Rossolovsky A.N., Kravchenya A.R., Manakhov G.A.
Organization: Saratov State Medical University
Summary:

Objective: to study the efficacy of surgical treatment of primary hyperparathyroidism in risk of uronephrolithiasis progression. Material and Methods. The research involved 55 patients, the biochemical and clinical parameters before and after treatment with retrospective-prospective method of analysis were studied and analyzed. Results. It is established that the surgical treatment of patients with uronephrolithiasis is proved to be effective in 96,4% of the cases, as it allows to eliminate the classic symptoms of primary hyperparathyroidism, and urolithiasis. Improvement of laboratory hormonal and biochemical indices of mineral metabolism, and, consequently, reducing the severity of risk factors of urolithiasis is marked. Conclusion. Surgical treatment of renal forms of primary hyperparathyroidism is a pathogeneti-cally reasonable method. Parathyroidectomy performed in an adequate amount prevents relapses and progression of diseases that are the consequence of primary hyperparathyroidism.

AttachmentSize
2018_2_265-267.pdf245.79 KB

Primary hyperpara-thyroidism: current state of the problem

Year: 2017, volume 13 Issue: №4 Pages: 849-853
Heading: Surgery Article type: Review
Authors: Kovalenko Yu.V., Tolstokorov A.S., Rossolovsky A.N., Kravchenya A.R., Manakhov G.A., Velikanova M.G.
Organization: Saratov State Medical University
Summary:

 The review is devoted to current state of the problem of primary hyperparathyroidism. One of the important steps in the study of pathology of parathyroid glands and their decision value in development of primary hyperparathyroidism was introduction of automated screening of the ionized calcium of plasma of blood to all patients asking for medical care. Understanding of the nature of this process allowed the doctors of many specialities to unite the efforts in the analysis of results of the already accumulated experience and extend possibilities of early preclinical exposure of this disease.

AttachmentSize
2017_04_849-8531.pdf278.36 KB

Professor K.I. Myshkin (to the 95-th birth anniversary)

Year: 2016, volume 12 Issue: №4 Pages: 625-627
Heading: Scientific schools and memorable dates Article type: Short message
Authors: Popkov V.M., Tolstokorov A.S., Zavalev V.I., Kurochkina E.N.
Organization: Medical Department of the Presidential Administration of the Russian Federation , Saratov State Medical University
Summary:

The article presents the biographical data of Professor K. I. Myshkin who is one of the most prominent representatives of the Saratov school of surgery. It describes the main directions of his scientific activity. Particular attention is paid to the contribution of K. I. Myshkin to the training of surgical staff for Saratov Medical Institute.

AttachmentSize
2016_04_625-627.pdf397.32 KB

The clinical significance of the prevalence of parapancreatitis in pan-creonecrosis

Year: 2016, volume 12 Issue: №1 Pages: 57-60
Heading: Surgery Article type: Original article
Authors: Alexandrov D.A., Tolstokorov A.S., Sedov D.S.
Organization: Saratov State Medical University
Summary:

Tftea/m of the study is to determine the relationship of clinical surgical treatment options of degradation of retroperi-tonealfat. Material and Methods. We have analyzed the results of treatment of 1177 patients with necrotizing pancreatitis, taking into account the severity and characteristics of parapancreatitis. Statistical data processing was carried out by the program Statistica for Windows 6.0. using the Student's criterion. Results. The variety of clinical forms of pancreatic necrosis due to a combination of options lesions of the pancreas and retroperitoneal fat. The outcome of pancreatic necrosis is determined not only by the degree of destruction of the pancreas, but also features parapancreatitis. The allocation of limited and common prevalence of parapancreatitis was substantiated and specified. Conclusion. The effectiveness of the treatment of pancreatic necrosis is dependent on the development options of parapancreatitis which present the predictive and tactical value.

AttachmentSize
2016_01_057-060.pdf347.01 KB

Experience of antireflux surgery application for the treatment of gastroesophageal reflux disease

Year: 2015, volume 11 Issue: №4 Pages: 583-586
Heading: Surgery Article type: Original article
Authors: Tolstokorov A.S., Khubolov A.M., Kovalenko Yu.V.
Organization: Saratov State Medical University
Summary:

Purpose of the study: post-hoc analysis of mid-term and late results of various types of antireflux surgery performed to treat hiatal hernia. Material and methods. We have studied results of post-surgery examination of 118 patients diagnosed with hiatal hernia, the examination being performed at various time intervals after surgeries. Results. The only benefits of using laparoscopic treatment include cosmetic effect, shorter terms of hospital stay and recovery of person's capacity to work. Conclusion. Analysis of immediate and late results of surgical treatment of gastroesophageal reflux disease as well as frequency of postsurgical relapses provided no certain evidence of significant beneficial effect for choosing laparoscopic surgical methods over traditional open surgery.

AttachmentSize
2015_04_583-586.pdf266.64 KB

Influence of socio-psychological status peculiarities on patients with obstructed inguinal hernia while concerning surgical treatment

Year: 2013, volume 9 Issue: №2 Pages: 328-332
Heading: Surgery Article type: Original article
Authors: Tolstokorov A.S., Lyakishev V.V., Selezneva T.D.
Organization: Saratov Road Clinical Hospital, Saratov State Medical University
Summary:

The research goal is to confront the duration of withholding operative therapy of obstructed inguinal hernias with peculiarities of medical and social and psychological status of patients. Materials and methods: 186 patients with inguinal hernias aged from 25 to 60 years were examined. Duration of withholding operative therapy was determined from the moment of officially established diagnosis to the moment of admission to surgical hospital. Results: Medical aid to patients with inguinal hernias who went to the hospital by themselves is no more than 29% and in most cases (53,6%) diagnosis is officially established while staying in health care institutions with other diseases, 94,6% of patients realized the fact that full recovery from inguinal hernias was possible only after surgical procedures. Conclusion: In the first year after establishment of diagnosis consent to surgical treatment of inguinal hernias is associated with the age under 30, higher education, the presence of partially or entirely unreduced inguinal hernia, prevalence of such qualities of charac-
ter as psychasthenia, paranoia, hypomania. In five-six years after official establishment of diagnosis patients aged over 50 years with higher education and prevailing of such qualities of character as hypohondria, depression, psychasthenia give their consent to surgical treatment of inguinal hernia regardless of its type and size.

AttachmentSize
2013-02_328-332.pdf255.16 KB

Prevention of papillosphincterotomic wound bleeding after endoscopic intervention on major duodenal papilla in choledo-cholithiasis

Year: 2012, volume 8 Issue: №4 Pages: 1012-1016
Heading: Surgery Article type: Original article
Authors: TolstokorovA. S., Sarkisyan Z. О., Goch Е.М., Skopets S. М., Dergunova S. A., Rakhnayev D. Y. Parab D.
Organization: Saratov State Medical University
Summary:

Objective of the study is to prevent bleeding from papillosphincterotomic wounds after endoscopic intervention. Methods: Analysis of the results of endoscopic intervention of patients receiving treatment at the Saratov regional hospital during the period from 2006 to 2010. Endoscopic papillotomy and papillosphincterotomy have been performed in 250 patients. Bleeding has been occurred in 21 (8.4%) of cases. Results: Bleeding from the PST or PT — wounds has occurred in self-discharge of CBD stones into duodenum. Conclusion: According to the observations, method of prevention of bleeding from PST-wound in choledocholithiasis has been proposed. It deals with the temporary installation of stent in the distal part of common bile duct for 2-4 days in multistage endoscopic operations.

AttachmentSize
201204-1012-1016.pdf241.56 KB

Genetic aspects of etiology and development of thyroid gland cancer

Year: 2012, volume 8 Issue: №3 Pages: 854-858
Heading: Surgery Article type: Review
Authors: Kovalenko Yu.V., Tolstokorov A.S.
Organization: Saratov State Medical University
Summary:

Recent studies on thyroid gland cancer development and progression have identified new classes of tumor markers, proto-oncogenes, tumor-suppressing genes, cell receptor genes, identified genetic tumor-predisposing polymorphism and some other significantly important segments of genome. The identification has been based mainly on revealing of DNA abnormal consequences, specific for occurrence of thyroid gland cancer and its progression.

AttachmentSize
201203-854-858.pdf256.66 KB

Method of prevention of acute pancreatitis after diagnostic and therapeutic endoscopic retrograde cholangiopancreatography

Year: 2012, volume 8 Issue: №3 Pages: 845-849
Heading: Surgery Article type: Original article
Authors: Tolstokorov A.S., Sarkisyan Z.О., Goch Е.М., Volchkov A.S., Skopets S.М., Dergunova S.A., Rakhnayev D.Ya.
Organization: Saratov State Medical University
Summary:

Objective of the study: Prevention of acute pancreatitis after diagnostic and therapeutic endoscopic retrograde cholangiopancreatography (ERCP). Material and Methods. Analysis of the results of diagnostic and therapeutic ERCP, of the patients treated at Saratov Regional clinical hospital f during the period from 2006 to 2010. Results, lincrease in pancreatic amylase levels in blood above 50 U/l till ERCP is a risk factor for development of acute pancreatitis after endoscopic retrograde cholangiopancreatography (ERCP). Conclusion. The above-stated follows to the background of increased pancreatic amylase levels in blood, performance of endoscopic retrograde cholangiopancreatography led to the development of acute pancreatitis.

AttachmentSize
201203-845-849.pdf262.84 KB