Saratov JOURNAL of Medical and Scientific Research

cognitive impairment

Early detection of cognitive impairment in patients with multiple sclerosis

Year: 2017, volume 13 Issue: №1 Pages: 164-168
Heading: Neurology Article type: Original article
Authors: Poverennova I.E., Romanova T.V., Zakharov A.V., Khivintseva E.V.
Organization: Samara State Medical University

The aim of the study was to examine cognitive impairment in patients with multiple sclerosis with an emphasis on the speed and efficiency of information processing. It was supposed to reveal the patterns of these disorders depending on the duration and severity of the disease. Material and methods. The study included 50 patients with established diagnosis of clinically significant multiple sclerosis, a relapsing-remitting course. The EDSS score was evaluated. Cognitive functions were assessed using SDMT and PASAT-3 tests. All patients underwent a study of cognitive evoked potential. All examined patients were divided into 2 groups depending on the duration of the disease. Results. Cognitive screening tests PASSAT and SDMT showed no correlation with the duration of the disease severity and cannot serve as a tool for screening early signs of cognitive impairment in young patients with multiple sclerosis. A significant increase in latency of the P300 potential was obtained with increasing duration and severity of the disease, which correlates with the severity of cognitive dysfunction. Conclusion. This study is the initial step in the search for a tool for screening early manifestations of cognitive impairment in patients with multiple sclerosis. In the future it is planned to expand the research with the modernization of its design.

2017_01-1_164-168.pdf292.07 KB

Affective and cognitive disorders at men and women with discirculatory encephalopathy

Year: 2012, volume 8 Issue: №2 Pages: 570-574
Heading: Neurology Article type:
Authors: Yakovlev N.A., Abramenko Y.V.
Organization: Tver State Medical University of the Ministry of Russia

The goal of the research was the comparative analysis of affective and cognitive disorders headache at women and men with dyscirculatory encephalopathy (DE), identify the connection of these disorders with the cerebral hemodynam-ics, neuroimaging of cinerea changes and BDNF in patients’ blood serum. 72 women (middle age 64,3±1,0) and 48 comparable in age and education men (middle age 65,0±1,2) with initiatory stages of dyscirculatory encephalopathy (DE) have been studied using comparative analysis of neuropsychological, sonographic and neuroimaging characteristics. The research revealed the predomination of cognitive impairment among men with (DE), especially attention, verbal coding and praxis disorders. Affective and insomnia disorders prevailed with women-patients. The results have shown possible links between low levels of brain-derived neurotrophic factor (BDNF) in blood plasma and the severity of depression and cognitive impairment at patients with (DE), especially at men. The received results may be important for individualization of therapeutic intervention.

201202_570-574.pdf292.65 KB