Saratov JOURNAL of Medical and Scientific Research

early diagnosis

Investigation of the oxidative status in patients with Parkinson's disease

Year: 2018, volume 14 Issue: №1 Pages: 132-135
Heading: Neurology Article type: Original article
Authors: Goncharova Z.A., Kolmakova T.S., Okseniuk O.S., Gelpey M.A., Isachkina N.S.

Currently, much attention is paid to the search for laboratory diagnostic tests for Parkinson's disease, which can be used to create a screening diagnostic panel. The aim of the research was to study markers of oxidative status in blood plasma and to correlate these indicators with the main clinical characteristics of Parkinson's disease. Material and Methods. The study included 32 patients of the main group and 21 patients as a control group. Blood was collected for the evaluation of total oxidative activity and general antioxidant status of the organism (OOAand OAA): determination of the activity of catalase, superoxide dismutase (SOD), malonic dialdehyde (MDA) in the blood serum by spectropho- tometric method. Results. The parameters of SOD, catalase, ОАА, OOA in patients with early stage of Parkinson's disease significantly differed from those of the control group Conclusion. Reduction of oxidative activity could slow down the development of the disease.

2018_01-1_132-135.pdf241.66 KB

Early diagnosis of masked hypertension in adolescents

Year: 2016, volume 12 Issue: №4 Pages: 574-578
Heading: Pediatrics Article type:
Authors: Ledyaev M.Ya., Mozoleva S.S., Gavrikov L.K.
Organization: Volgograd State Medical University

Objective: to improve diagnosis of latent arterial hypertension by studying the characteristics of hemodynamics and the rigidity of the vascular walls of the arteries in adolescents with this phenomenon. Material and Methods. The study involved 147 children aged 11 to 18 years who did not have heart rhythm disorders, congenital heart defects, endocrine diseases and diseases of the kidneys. They were divided into three groups on the basis of blood pressure values (BP) obtained during three measurements of blood pressure according to the method of N. S. Korotkov and when conducting 24-hours ambulatory blood pressure monitoring (ABPM). Group 1 included children with blood pressure values in the range from 5 to 95 percentile. Group 2 was composed children with masked hypertension (values of office blood pressure in the range from 5 to 95 percentile but indicators of ABPM of blood pressure is greater than 95 percentile). Group 3 included children with stable arterial hypertension (blood pressure values exceeded the 95 percentile). The study was a comparative analysis of the hemodynamic and rigidity (stiffness) of the arteries. Results: Most hemodynamic parameters in children with masked hypertension were higher than in children of group 1. However, these figures were lower than in children with stable arterial hypertension. Among the indicators of the rigidity of the arteries, the most sensitive indicator (dP/dt) max was maximum rate of pressure rise. Children with masked hypertension had increased arterial stiffness, however it was lower than in children with stable arterial hypertension. Conclusion: The use of BPLab monitor with technology Vasotens allows physicians to evaluate the daily profile of arterial pressure, the hemodynamics and stiffness of blood vessels, which is an important step for early diagnostics of latent arterial hypertension in children

2016_04_574-578.pdf262.79 KB

The diagnostic reliability of outpatient neurological care to patients with Parkinson’s disease

Year: 2012, volume 8 Issue: №2 Pages: 513-517
Heading: Neurology Article type: Original article
Authors: Razdorskaya V.V., Voskresenskaya O.N., Yudina G.K.
Organization: First Moscow State Medical University n.a. I.M. Sechenov, Saratov State Medical University

Goal: discussion of the revealing aspects of Parkinson’s disease (PD) by ambulatory neurologists. Techniques: a longitudinal epidemiological survey on applications to a specialized clinic. Results. 603 patients with Parkinsonism suspicions were examined for a four-year period. The syndromal diagnosis of Parkinsonism/extra pyramidal syndrome was correctly recognized by ambulatory neurologists in ca. ¾ of the whole contingent of patients. Hypodiagnostics of PD was the most frequent mistake (71 of 146 corrected diagnoses). Hyperdiagnostics of PD followed by frequency (57 of 146 corrected diagnoses). Every ffth patient applied for consultation caused diffculties in the ambulatory chain. Conclusion. The diagnostic mistakes, no provisional diagnosis for every tenth PD patient cause justifed anxiety in the patients regarding the quality of guaranteed medical aid and force them to apply for specialized consulting reception individually.

201202_513-517.pdf438.4 KB