Saratov JOURNAL of Medical and Scientific Research

Kamenskih I.D.

Saratov State Medical University n.a. V.I. Razumovsky Clinic of Eye Diseases, Ophthalmologist

Evaluation of the effectiveness of antiglaucomic operations with the use of the Ex-Press mini glaucoma shunt and Repegel-1 drainage in patients wi

Year: 2017, volume 13 Issue: №2 Pages: 394-400
Heading: Ophtalmology Article type: Original article
Authors: Kamenskikh T.G., Veselova E.V., Filatova V.S., Lyakhovich V.V., Golub' L.K., Karpenko A.A., Alekseyeva E.l., Kamenskikh I.D.
Organization: Saratov State Medical University
Summary:

The purpose of study is to evaluate the effectiveness of antiglaucomic operations with the use of the Ex-Press mini glaucoma shunt and Repegel-1 drainage in patients with primary open-angle glaucoma. Material and Methods. 65 patients (65 eyes) with an established diagnosis of uncompensated primary open-angle glaucoma of Stage III were observed. All patients underwent anti-glaucoma surgery. Patients of group 1 (15 patients, 15 eyes) underwent penetrating deep sclerectomy with implantation of the Ex-Press mini shunt under the scleral flap. Patients of group 2 (25 patients, 25 eyes) — penetrating deep sclerectomy with Repegel 1 drainage. Patients of group 3 (25 patients, 25 eyes) underwent sinus trabeculectomy without drainage. Results. In the early postoperative period, a good hypotensive effect was obtained in patients of all three groups. The most persistent antihypertensive effect was obtained in patients who underwent anti-glaucoma surgery with Repegel-1 drainage implantation. In patients who were implanted with the Ex-Press mini shunt, there was a significant decrease in the perimetrical MD index for 3 months. Conclusions. 1. Improvement of the photosensitivity of the retina in patients who underwent an antiglaucoma operation with Ex-Press shunt implantation, possibly due to the low invasiveness of the intervention and the absence of a sharp drop in IOP level. 2. Preliminary results (analysis 3 months after the operation) indicate a lower number of postoperative complications in the implantation of Repegel-1 drainage and a persistent hypotensive effect. 3. Patients who underwent antiglaucoma operations with implantation of drainage systems showed improvement of hemodynamic parameters in the pool of posterior short ciliary arteries in the postoperative period.

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Clinical and immunological parallels in the diagnosis of primary open-angle glaucoma.

Year: 2017, volume 13 Issue: №2 Pages: 378-383
Heading: Ophtalmology Article type: Original article
Authors: Kamenskikh I.D., Kamenskikh T.G., Kolbenev I.O., Zakharova N.B., Kozletsov A.P., Tuchin V.V.
Organization: Saratov State Medical University, Saratov state university, Yuri Gagarin State Technical University of Saratov
Summary:

The purpose of study is an assessment of the informative value of various diagnostic parameters in monitoring and prognosis of the state of the visual organ in patients with primary open-angle glaucoma. Material and methods. 216 patients (216 eyes) were examined. 126 patients (126 eyes) with the diagnosis of primary open-angle glaucoma I, II or III stage were included in the main group (I), and 90 patients (90 eyes) without ophthalmologic pathology were included in the control group (II). All patients underwent complex examination. Laser confocal scanning tomography for the analysis of the optic disc morphology was performed using a Heidelberg Retina Tomograph II from Heidelberg Engineering (Germany). Evaluation of the field of view was carried out using the computer static perimeter Oculus twinfield-2 (Germany). Electrophysiological studies (apparatus Roland Consult, Germany) included: the study of visual cortical potentials on the outbreak, the pattern-electroretinogram, photopic negative response. Neurotrophic brain factor, ciliary neurotrophic growth factor and protein NF-200, S-100 protein, monocyte chemoattractant, vascular endothelial growth factor were determined in the serum. Results. An increase in the concentration of the S-100 protein with progression of POAG testifies to the existence of parallels between apoptosis of retinal ganglion cells and systemic neurodegenera-tion affecting the central nervous system as a whole. The importance of electrophysiological research methods, which give information about the third neuron of the visual pathway, has been confirmed. Pattern-electroretinogram, photopic negative response most reflect abnormalities in the work of ganglion cells of the retina, including before the appearance of structural changes in the optic disc and the retina. Conclusion. The interrelation of dynamics of functional, morphological and immunological criteria of progression of POAG is revealed, which allows to predict the further course of the pathological process. Since the study involved patients with IOP target values, it is important not only to maintain IOP on target values, but also to carry out neuroprotection.

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Comparative analysis of the results of various physical therapy techniques in the treatment of patients with primary open-angle glaucoma with chronic cerebral ischemia

Year: 2012, volume 8 Issue: №2 Pages: 445-452
Heading: Neurology Article type: Original article
Authors: Kamenskih T.G., Raigorodskij Y.М., Veselova E.V., Mishkina E.J., Kolbenev I.O., Lazarev М.S., Kamenskih I.D.
Organization: Saratov State Medical University
Summary:

Aim of the study: to evaluate the effectiveness of the techniques of dynamic simultaneous transcranial magnetic therapy and resonance, and electrical stimulation, transcranial magnetic therapy and dynamic laser stimulation, magnetic simpatokorrektsii in the treatment of patients with primary open-angle glaucoma with chronic cerebral ischemia. Techniques. We observed 184 patients diagnosed with primary open-angle glaucoma who received different physical therapy techniques. Results. Patients treated with transcranial magnetic therapy and electrical stimulation or laser stimulation, in addition to improving visual function and improve the bioelectrical activity of the visual cortex, more pronounced than in other groups also observed the activation of the intraocular blood fow. Application of magnetic simpatokorrektsii allows for improvement of basic functional, electrophysiological and hemodynamic performance by reducing the activity of the sympathetic nervous system and reduce the vasopressor effect. Conclusion. Transcranial magnetic therapy in combination with electrical stimulation or laser stimulation is effective in the treatment of patients with POAG. In patients with primary open-angle glaucoma with chronic cerebral ischemia technique of magnetic sim-patokorrektsii compared with traditional methods of vasoactive therapy is more effective, which is manifested not only increase the visual functions, but also a decrease in cognitive impairment.

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