Saratov JOURNAL of Medical and Scientific Research

Rostov State Medical University of Ministry of Health and Social Development of the Russian Federation

Pathogenetic significance of biochemical markers in evaluation of nail destruction

Year: 2013, volume 9 Issue: №2 Pages: 286-290
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Urazovskaya E.V. Mikashinovich Z.I.
Organization: Rostov State Medical University of Ministry of Health and Social Development of the Russian Federation

The purpose of the article is to evaluate the state of metabolic status of patients with distal onycholysis of hands. Materials and methods: Evaluation of hemoglobin, red blood cells, neutrophil granulocytes, the level of glycolytic processes of lactate and pyruvate, the activity of superoxide dismutase, catalase, myeloperoxidase, neutrophil elastase, serum alkaline phosphatase activity, as well as degradation products content of collagen structures to relative fractions of the blood free and peptide bound oxyproline. Results: It has been shown that free fraction oxyproline in 18 women with distal onycholysis of hands and hemoglobinemia prevails over peptide bound oxyproline fraction in blood, activated glycolytic processes on the modulation mechanism of adaptation with a slight increase of the lactate and pyruvate, the inhibition of activity of antioxidant enzymes, alkaline phosphatase and serum first phase elongation of blood coagulation as a result of the activated plasma recalcification time. Conclusion: The functional state of red blood cells, neutrophil granulocytes in the oppression of the first line of antioxidant enzyme defense and extension in patients with distal onycholysis of hands points to the formation of a mixed type of chronic hypoxia.

2013-02_286-290.pdf242.56 KB

Pathomorphism of the clinical picture of multiple sclerosis in rostov region


The goal of the research is to analyze the dynamics of the clinical picture at multiple sclerosis (MS) patients living in Rostov region, who got the disease over the 1965 to 2010 period. The clinical data of 505 MS patients have been analyzed (age, gender, MS onset peculiarities, speed of MS progression, the time of reaching 3,4 and 6 EDSS scores). Worsening of the natural MS course over recent decades in population of Rostov region has been identifed. Taking into account the multifactor nature of multiple sclerosis, the fact of worsening can be explained by the increase of negative environmental infuence, which should be considered while medico-prophylactic organizations.

Keywords: Rostov region
201202_416-419.pdf261.77 KB