Saratov JOURNAL of Medical and Scientific Research

Goncharova Z.A.

Rostov State Medical University of Ministry of Health and Social Development of the Russian Federation, Department of Neurology and Neurosurgery, Associate Professor, Candidate of Medical Science

Distinguishing features of the range of serum antibodies to nervous tissue antigens in Parkinson's disease

Year: 2019, volume 15 Issue: №1 Pages: 151-154
Heading: Neurology Article type: Original article
Authors: Goncharova Z.A., Kolmakova T.S., Oksenjuk O.S., Morgul E.V., Gelpey M.A., Vlasova N.D., Kalmykova Yu.A.
Organization:
Summary:

The goal of this study was to perform a multivariable analysis of immunobiochemical parameters which reflect the state of nervous system microstructure in Parkinson's disease (PD). Materials and Methods. The study included 54 patients of the main group with a diagnosis of PD and 6 patients of the control group. The immunoreactivity profiles of natural regulatory auto-AB in serum were determined by ELISA using the ELI-P-Complex assay. The following parameters were assessed: ABto NF-200, GFAP, S100 proteins, MBP, beta-endorphin, voltage dependent Ca2+channel, H-cholinergic receptors, glutamate, dopamine, serotonin, opiate, GABA receptors. Results. The study revealed significant abnormalities in auto-AB profiles of the examined patients. Conclusion. The findings on the difference in range of auto- AB dependent on the duration of the disease and the revealed associations with the main characteristics of the disease can be used both for early diagnosis and for predicting the course of PD in the future.

AttachmentSize
2019_01-1_151-154.pdf272.7 KB

Investigation of the oxidative status in patients with Parkinson's disease

Year: 2018, volume 14 Issue: №1 Pages: 132-135
Heading: Neurology Article type: Original article
Authors: Goncharova Z.A., Kolmakova T.S., Okseniuk O.S., Gelpey M.A., Isachkina N.S.
Organization:
Summary:

Currently, much attention is paid to the search for laboratory diagnostic tests for Parkinson's disease, which can be used to create a screening diagnostic panel. The aim of the research was to study markers of oxidative status in blood plasma and to correlate these indicators with the main clinical characteristics of Parkinson's disease. Material and Methods. The study included 32 patients of the main group and 21 patients as a control group. Blood was collected for the evaluation of total oxidative activity and general antioxidant status of the organism (OOAand OAA): determination of the activity of catalase, superoxide dismutase (SOD), malonic dialdehyde (MDA) in the blood serum by spectropho- tometric method. Results. The parameters of SOD, catalase, ОАА, OOA in patients with early stage of Parkinson's disease significantly differed from those of the control group Conclusion. Reduction of oxidative activity could slow down the development of the disease.

AttachmentSize
2018_01-1_132-135.pdf241.66 KB

Clinical and immunological features of multiple sclerosis combined with persistent herpes viral infection

Year: 2018, volume 14 Issue: №1 Pages: 126-132
Heading: Neurology Article type: Original article
Authors: Goncharova Z.A., Belovolova R.A., Megerian V.A.
Organization: City Hospital №1 n.a. N.A. Semashko
Summary:

The purpose of the study is to evaluate the symptomatology of multiple sclerosis (MS) and to evaluate the immune status in patients with reactivation of persistent herpes viral infection (PHVI). Material and Methods. We examined 56 patients with definite multiple sclerosis (MS) and 20 patients treated for other diseases of nervous system (radicu-iar syndrome caused by degenerative disease backbone) (comparison group). The MS patients were divided into 2 groups: patients without reactivation of PHVI (typical MS) and patients with reactivation of PHVI (virus-associated MS). The PHVI reactivation was registered in the case of presence of the appropriate clinical features and it was also verified by serological methods (ELISA). The symptomatology of MS was evaluated according to FS and EDSS scales. We performed the study of cell and humoral adaptive immunity. Results. Patients with reactivation of PHVI had more significant neurological symptomatology, more frequent relapses of MS, a higher speed of MS progression compared with typical MS patients. The immune status features in virus-associated MS patients can be estimated as a combination of secondary immunodeficiency (T-cell mediated) and active autoimmune process (the activation of B-cell component). Conclusion. It was revealed more significant neurological symptomatology, severer MS course and markers of secondary immunodeficiency in MS patients with reactivation of PHVI.

AttachmentSize
2018_01-1_126-132.pdf305.25 KB

Epidemiology analysis of Parkinson's disease in Rostov-on-Don

Year: 2017, volume 13 Issue: №1 Pages: 135-139
Heading: Neurology Article type: Original article
Authors: Goncharova Z.A., Rabadanova Е.А., Gelpey M.A.
Organization:
Summary:

In orderto improve the assistance provided to patients with Parkinson's disease (PD) it is necessary to conduct epi-demiological analysis, the establishment of the register, the clinical analysis. In Rostov-on-Don (population: 1114806 on 01.12.2015) epidemiological analysis of PD is carrying out for the first time. The aim of this study was to analyze the main epidemiological indicators of PD in the population of Rostov-on-Don to support, organize and optimize the system of treatment and preventive care for these patients. Material and methods. The object of study was 661 patients (415 women and 246 men). Results. Epidemiological analysis of PD in Rostov-on-Don has shown that the prevalence and incidence of line with the average for the country. We have revealed the hypodiagnostics at the first stage of the disease. We have also identified gender features: the predominance of women, which is contrary to the results of most studies that have demonstrated the predominance of men. We have found that in 16.9% PD first symptoms were observed in aged under 60 years, i.e. in people of working age. Conclusion. Establishment of a register and the city center of diagnostics and treatment of extrapyramidal disorders has improved diagnosis and quality of follow-up for these patients. It is needed to improve the quality of diagnosis by general practitioner.

Keywords: -
AttachmentSize
2017_01-1_135-139.pdf242.03 KB

Influence of non-motor symptoms on the Parkinson's disease features and on quality of patients' life

Year: 2016, volume 12 Issue: №3 Pages: 362-366
Heading: Neurology Article type: Original article
Authors: Goncharova Z.A., Gelpey M.A., Rabadanova E.A.
Organization:
Summary:

The main clinical symptoms of PD are well understood, but it is necessary to continue studying the changes of symptoms as it progresses. The aims of the research were: to study the structure of non-motor symptoms (NMS) at the early and last stages of PD, to determine the frequency and clinical significance of the NMS at different stages of PD, comparing the severity of NMS in PD with the severity of the same symptoms in the natural aging, to study the quality of life (QOL) of patients with the impact assessment of the NMS and the assessment of motor symptoms on this criterion. The material and methods. The study included 79 patients with PDand 25 patients without neurodegenerative disorders (control group). The degree of movement disorders severity was assessed using UPDRS scale. Cognitive function was assessed using the Montreal Cognitive Rating Scale (MoCA). To identify and assess the severity of NMS questionnaire used NMSS. Assessment of quality of life of patients was carried out by PDQ-39 questionnaire. Results. There was a significant difference between the intensity of the NMS in PD patients and the control group. Intensity of NMSs significantly correlated with disease stage, disease duration, with the points on the UPDRS scale. Conclusion. NMS significantly affect the quality of life, their severity and structure varies considerably from early to late stage PD, and they are the result of a neurodegenerative process, inherent in PD, and not the natural aging process.

AttachmentSize
2016_03_362-366.pdf296.39 KB

Pathomorphism of the clinical picture of multiple sclerosis in rostov region

Summary:

The goal of the research is to analyze the dynamics of the clinical picture at multiple sclerosis (MS) patients living in Rostov region, who got the disease over the 1965 to 2010 period. The clinical data of 505 MS patients have been analyzed (age, gender, MS onset peculiarities, speed of MS progression, the time of reaching 3,4 and 6 EDSS scores). Worsening of the natural MS course over recent decades in population of Rostov region has been identifed. Taking into account the multifactor nature of multiple sclerosis, the fact of worsening can be explained by the increase of negative environmental infuence, which should be considered while medico-prophylactic organizations.

Keywords: Rostov region
AttachmentSize
201202_416-419.pdf261.77 KB