Saratov JOURNAL of Medical and Scientific Research


Possible laboratory and instrumental markers of Parkinson's disease

Year: 2020, volume 16 Issue: №1 Pages: 336-341
Heading: Neurology Article type: Original article
Authors: Goncharova Z.A., Kolmakova T.S., Oksenyuk O.S., Morgul E.V., Gelpey M.A., Vlasova N.D., Smirnova O.B., Mutalieva Kh.M.

Objective: to evaluate the role of a complex of markers of inflammatory processes and free radical oxidation, an immunoreactivity profile, stabilographic indicators in the pathogenesis of Parkinson's disease (PD) for possible use as clinically significant markers of early diagnosis of the disease. Material and Methods. 139 patients with PD, 31 patients as the control, and 11 patients as the comparison with Parkinson's syndrome were examined. The following parameters were evaluated in blood serum: antidodies to NF-200, GFAP, S100, MBP, voltage-dependent-Ca-chan-nel, Na-Choline, glutamate, dopamine, serotonin, Mu-Opiate, GABA receptors, (3-Endorphin; total antioxidant activity; malondialdehyde's accumulation; determination of small, medium, large and giant circulating immune complexes and medium-weight molecules. Postural functions were evaluated using a biofeedback computer stabilizer. Results. Significant differences in the profiles of immunoreactivity, neuroinflammation and endogenous intoxication in patients and in the control group were revealed. The stabilometric indicator of the quality of the equilibrium function significantly varied depending on the stage of PD. Conclusion. The results indicate a possible role of activation of the immune system and neuroinflammation in the process of neurodegeneration in PD. The autoimmune response is specific in nature, progressively changing depending on the stage of the disease.

2020_01-3_336-341.pdf347.25 KB

Biomechanical criteria of orthopedic status of patients with dysplastic coxarthrosis (Crowe) IV before and after treatment

Year: 2017, volume 13 Issue: №3 Pages: 520-526
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Yusupov K.S., Barabash Yu.A., Pavlenko N.N., Romakina N.A., Anisimova E.A., Letov A.S., Sertakova A.V., Anisimov D.l.
Organization: Scientific Research Institute of Traumatology Orthopedics and Neurosurgery of Saratov State Medical University n.a. V.I. Razumovsky

The aim: to analyze locomotor function of lower limbs in patients with dysplastic coxarthrosis Crowe IV type before and after single-step hip joint endoprosthesis and femoral bone osteotomy conducted by our own technology. Material and Methods. 42 patients with one-side dysplastic coxarthrosis Crowe IV type were examined and operated. The mean age at the time of admission in men was 47.3±1.2 years, women — 46.1 ±1.1 years. Static and kinematic function of lower limbs was evaluated with the help of stabilometrics and podometry before and one year after the operation. Results. Before treatment, the patients had deviations of static and dynamic function of locomotor system stabilometri-cally seen as instability in upright position and podographically as a compromised gait. One year postsurgically we indicated static balance between the limbs within the normal range, expanded motoring mode, which was supported by significant improvement in the biomechanical characteristics of locomotor function of the patients. Conclusion. Total hip replacement in combination with modifying osteotomy of the hip conducted by a unique technique restores static and kinematic function of lower limbs in patients with high congenital hip dislocation (dysplastic coxarthrosis Crowe type IV) which is proved by stabilographic and podographic indices one year after operation.

2017_03_520-526.pdf671.05 KB

Objective assessment of postural function and falls prevention

Year: 2016, volume 12 Issue: №2 Pages: 250-253
Heading: Neurology Article type: Review
Authors: Akhmadeeva L.R., Kharisova Е.М.
Organization: Bashkir State Medical University of the Russian Health Care

A literature review on evaluation of postural function in elderly patients is presented in the article. The detailed description of the main methods of diagnostics of balance disorders is given in the work.

2016_02-1_250-253.pdf230.35 KB

Application of techniques of biomechanics in the status evaluation and pathology correction of locomotor system

Year: 2015, volume 11 Issue: №3 Pages: 310-316
Heading: Traumatology and Orthopedics Article type: Review
Authors: Romakina N.A., Fedonnikov A.S., Kireev S.I., Bakhteeva N.Kh., Norkin I.A.
Organization: Saratov State Medical University

The article deals with the problem of development and the modern state of biomechanics as a scientific and practical direction in medicine under the context of technological advance herein a specific attention is paid to the achievements of the Russian schools. It is shown a necessity of wide usage of instrumental biomechanical diagnostics of locomotive disorders for intrinsic substantiation of rehabilitation treatment tactics and monitoring of its medical efficiency particularly for persons with remote effects of surgical interventions such as osteosynthesis, spondylosynthesis, total joint replacements. Non-invasive technique, possibility of its multiple application and rather low cost make actual using of locomotion clinical analysis techniques for rehabilitation treatment of concerned patients of different age groups.

2015_03_310-316.pdf313.08 KB

The study of a balance function using video stabilom-etry in patients with ataxia

Year: 2013, volume 9 Issue: №1 Pages: 92-97
Heading: Otolaryngology Article type: Original article
Authors: Mareev О.V., Sholomov I.I., Gorozhankin А. V., Monakhova O.A.
Organization: Engels Technological Institute of Saratov State Technical University n.a. Yu.A. Gagarin

The aim of the study is to assess the condition of balance function in patients with different diseases. Materials and methods: The study has been performed on 82 patients divided into the following groups: patients with Menier»s disease, with multiple sclerosis, chronic cerebral ischemia, and persons without pathology of balance function, which have composed the comparison group. Statistical evaluation of video stabilometric data of patients in these groups has been performed. Results: Reliable differences between stabilometric parameters in patients with disorder of balance function and patients of comparison group have been revealed. Conclusion: Video stabilometry may be applied as an objective method for evaluation of balance function in order to detect different pathological states.

2013-01_092-097.pdf456.1 KB

Infuence of depression on stability in elderly patients with discirculatory encephalopa-thy

Year: 2012, volume 8 Issue: №2 Pages: 383-388
Heading: Neurology Article type: Original article
Authors: Baidina T.V., Sosnitskaya D.M.
Organization: Perm State University of Medicine n.a. academician E.A. Vagner

The goal of the research is studying of patients who suffer from disequilibrium because of the gerontal dyscir-culatory encephalopathy (DE) with borderline disorders. The research also highlights possible relationship between depression and postural abnormalities using stabilometrics. 72 patients of 75 – 90 years old with dyscirculatory en-cephalopathy were examined. There were clinical and psychometric trials. Mental depression was detected according to depressive disorder criteria of ICD-10 (International Classifcation of Deseases-10th revision). Clinical assessment of static sense according to R. Bohannon scale (1989). Stabilometrics was carried out in compliance with European open eyes — methodology using “MBN — Biomechanics” complex (Moscow).During the tests two groups of patients were sorted out. They are the main group consisted of 56 patients with depressive symptom and a group for comparison consisted of 16 patients without anxiety or depression. The groups are comparable to age and cognitive defect rate. There was no difference according to clinical assessment of static sense according to R. Bohannon scale. The length and the area of a stabilogram, the centre of pressure movement speed in the main group is higher because the oscillation amplitude in the medium frequency area in frontal plane.The research concluded that depression intensifes balance disorder at patients with gerontal dyscirculatory en-cephalopathy. This disorder can be revealed by computer stabilometrics method. These disorders are the consequences of the infuence of phrenopathy on muscle tone.

Keywords: stabilometrics
201202_383-388.pdf307.76 KB