Saratov JOURNAL of Medical and Scientific Research

cancer genesis

The question of a 'New Era in the Low Dose Radiation Epidemiology' approach

Year: 2016, volume 12 Issue: №4 Pages: 654-662
Heading: radiation medicine Article type: Review
Authors: Koterov A.N., Ushenkova L.N., Biryukov А.Р., Samoilov A.S.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

The historical and recent years data on cancer and/or leukemia rate increasing after exposure of people in low dose (up to 100 mGy) radiation with a low LET, attributiveness of effects and the possibility of their experimental confirmation were considered. Previously, information about the carcinogenic effects of low doses was not clearly interpreted due to the presence of uncertainty, biases and confounders. The biological mechanism was also absent. In the last 5-7 years the situation has changed dramatically: more significant data were obtained: irradiation at computed tomography in dentistry, for residents of a high natural background radiation, and others. Simultaneously it was obtained radiobio-logical data on increased DNA double strand breaks level after exposure to doses from few milligrays and it can be considered as a possible molecular mechanism of these effects. As a result, was declared 'New Era in the Low Dose Radiation Epidemiology' (Kitahara С M., et al., 2015), which can lead to costs in terms of tightening of radiation risks and to fear of medical exposure. The conducted in the review analysis of recent epidemiological and radiobiological evidence suggests, however, that there is no unambiguous evidence of attributed to radiation carcinogenic effects, identified during the 'New Epidemiology of Low Doses', and there is no a proven molecular mechanism that could provide biological plausibility of such effects.

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То the theory and practice of psychosomatics

Year: 2012, volume 8 Issue: №2 Pages: 193-198
Heading: Clinical Psychology Article type: Author's opinion
Authors: Khaykin A.V.
Organization: Rostov-on-Don
Summary:

The article considers the main theoretical issues of psychosomatics. It provides an overview of psychosomatic genesis models. The hypotheses of psychobiological nature of cancer and the mechanism of the placebo effect have been under the study. The general model of psychosomatic work has been worked out. The article provides a brief overview of psychotherapeutic techniques used in the work with somatic diseases, where the main attention has been paid to the procedural and hypnotherapeutic techniques. It discusses the integration of psychosomatics and somatic medicine

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