Saratov JOURNAL of Medical and Scientific Research

vascular endothelial growth factor

Vascular endothelial growth factor as a risk predictor of thromboembolic complications in patients with orthopaedic profile

Year: 2016, volume 12 Issue: №3 Pages: 354-358
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Vorobeva I.S., Nikitina V.V., Gladilin G.P., Ivanenko I.L.
Organization: Saratov State Medical University
Summary:

Objective: to determine the risk of thromboembolic complications in orthopaedic patients. Material and methods. A survey of 151 patients who had undergone total endoprosthesis of large joints of the lower extremities, aged 25-68, under treatment in Saratov Scientific Research Institute of Orthopedics and Traumatology. Results. The performed research allowed to establish that at values of the content of VEGF-A to 183,6 PG/ml a low risk of thromboembolic complications was predicted and for values above 183,6 PG/ml high risk was prognosed. Conclusion. We have proved high efficiency of using the relationship of VEGF and PAI-1 in serum, which plays a leading role in the development of predisposition to thrombosis.

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2016_03_354-358.pdf1.14 MB

Vascular endothelial growth factor as a risk predictor of thromboembolic complications in patients with orthopaedic profile

Year: 2016, volume 12 Issue: №3 Pages: 354-358
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Vorobeva I.S., Nikitina V.V., Gladilin G.P., Ivanenko I.L.
Organization: Saratov State Medical University
Summary:

Objective: to determine the risk of thromboembolic complications in orthopaedic patients. Material and methods. A survey of 151 patients who had undergone total endoprosthesis of large joints of the lower extremities, aged 25-68, under treatment in Saratov Scientific Research Institute of Orthopedics and Traumatology. Results. The performed research allowed to establish that at values of the content of VEGF-A to 183,6 PG/ml a low risk of thromboembolic complications was predicted and for values above 183,6 PG/ml high risk was prognosed. Conclusion. We have proved high efficiency of using the relationship of VEGF and PAI-1 in serum, which plays a leading role in the development of predisposition to thrombosis.

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2016_03_354-358.pdf1.14 MB

Content of vascular endothelial growth factor in blood serum and gastric juice in children with chronic inflammatory diseases of stomach and duodenum

Year: 2014, volume 10 Issue: №1 Pages: 110-113
Heading: Pediatrics Article type: Original article
Authors: Zavyalova O.V., Spivakovsky У.М., Zakharova N.B., Lukina O.A., Sirotkin E.A.
Organization: Saratov State Medical University
Summary:

The aim: to assess the levels of vascular endothelial growth factor (VEGF) in children with chronic inflammatory diseases of stomach and duodenum. Material and methods. 67 children with chronic inflammatory diseases of gastroduo-denal zone have been investigated. The substrate of the study included the serum and portion of gastric content. The data obtained were compared with a group of healthy children. Results. Maximum high content of VEGF was identified in children with duodenal ulcer. Conclusion. The content of this indicator depended on the Helicobacter pylori infection.

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The diagnostic value of biomarkers of inflammation, angiogenesis and fibrogenesis to assess the severity of urodynamic obstruction in children with congenital megaureter

Year: 2012, volume 8 Issue: №4 Pages: 996-1001
Heading: Urology Article type: Original article
Authors: Morozov D.A., Krasnova E.I., Deryugina LA., Zakharova N.B., H'icheva Yu.A.
Organization: Saratov State Medical University, Clinical hospital n.a. S. R. Mirotvortsev SSMU, Moscow Research Institute of Pediatrics and Pediatric Surgery
Summary:

The aim of the study is to determine the diagnostic value of urine biomarkers of inflammation (interleukin-1p, tumor necrosis factor-a), angiogenesis (vascular endothelial growth factor) and fibrogenesis (monocyte chemoattractant protein-1, matrix metalloproteinase-9) to assess the severity of urodynamic obstruction of the ureter. Materials and Methods — Complex investigation of 47 children with congenital nonrefluxing megaureter at the age from 1 month till 11 years is carried. Results. The correlation between the urine level of IL-1p and main laboratory criteria of inflammation occurred, so IL-1p as an integrative indicator of pyelonephritis activity was appeared. The relation between levels of VEGF and MCP-1 and indicators of renal hemodynamics allowed to consider increased levels of these factors as markers of irreversible nephrosclerosis. The urine level of MMP-9 was strongly correlated with parameters of peristalyic activity of the ureter. The group of children with lower peristalyic activity of the megaureter was significantly different from group with normal ureteral peristalsis by the high urine level of MMP-9. We do not have reliable data about the diagnostic value of determination of the urine level of TNF-a in children with congenital megaureter. Conclusion: The urine level of biological markers investigations are very important for clinical practice for determination of pyelonephritis activity (IL-1p), severity of ischemic deterioration of renal parenchyma (VEGF, MCP-1). Further studies are needed to clarify the pathogenic role of MMP-9 in the regulation of peristalyic activity of the ureter during embryonic and postnatal development in patients with congenital nonrefluxing megaureter.

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Vascular endothelial growth factor as a marker of development of relapses in the postoperative period in kidney and bladder tumors

Year: 2011, volume 7 Issue: №3 Pages: 711-714
Heading: Urology Article type: Original article
Authors: Durnov D.A., Mikhailov V. Yu., Zakharova N.B., Ponukalin A.N.
Organization: Saratov State Medical University
Summary:

Aim: The article considers the results of research of the vascular endothelial growth factor (VEGF) in blood serum in patients with kidney and bladder tumors after surgical intervention. Materials and methods: The total of investigated patients consisted of 75 primary patients with kidney cancer (stages pT1-pT3N0M0), 75 patients with non-muscle-invasive bladder cancer (NMIBC), stages pTa-1NxMoG1-3, 25 patients with cysts of kidneys and 30 healthy patients. Results of research of content of VEGF in patients with kidney cancer and NMIBC in the postoperative period confirmed the role of angiogenesis processes both in the development of tumoral tissue and relapses of disease. Conclusion: Investigations of VEGF in blood serum may be additional method of revealing kidney cancer and NMIBC after surgical treatment of relapses of disease and may influence on the duration of recurrence-free period

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