Saratov JOURNAL of Medical and Scientific Research


Dynamics of angiogenesis and inflammation biomarkers in patients with urolithic disease with obstructive uropathy

Year: 2017, volume 13 Issue: №3 Pages:
Heading: Urology Article type: Original article
Authors: Popkov V.M., Zakharova N.B., Ponukalin A.N., Polozov A.B., Khotko D.N., Khotko A.l., Spirin P.V.
Organization: Scientific Research Institute of Traumatology Orthopedics and Neurosurgery of Saratov State Medical University n.a. V.I. Razumovsky

Purpose: to establish the nature of changes in markers of angiogenesis and inflammation in the blood serum and urine in patients with obstruction of the ureteropelvic segment or upper third of the ureter by ureteral stones in different terms of the kidney drainage. Material and Methods. 53 patients with urolithiasis have been examined. The main group consisted of 33 patients with concrements of the upper third of the ureter or renal pelvis-ureteral segment with pres- ent obstructive uropathy. The comparison group consisted of 20 patients with calculi of the kidney without symptoms of obstruction. In the main group patients underwent drainage of the kidney by percutaneous-nephrostomy puncture. Results. Patients of the main group revealed a significant increase in the levels of markers of angiogenesis and inflammation before the kidney drainage. The level of MCP-1 correlated with the level of serum creatinine. In the process of drainage the levels of these markers were decreased as a result of increased GFR. Determination of the concentration of urinary VEGF, IL-8 and MCP-1 in patients may have clinical value in personalized management of patients with obstructive uropathy to determine the optimal terms of the second stage of the surgical intervention. Conclusion. Determination of markers of inflammation and angiogenesis in the urine of patients in conjunction with assessment of renal function by creatinine level is important for determining the term of kidney drainage.

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General methods of identification of narcotic substances in cadaveric urine and biochemical indices in blood at positive identification of drug substances

Year: 2011, volume 7 Issue: №3 Pages: 642-646
Heading: Narcology Article type: Original article
Authors: Bychkov E.N., Serkova S.A., Arsentieva L.A., Frantsuzova T.S., Bluvshtein G.A., Borodulin V.B.
Organization: Saratov State Medical University, Saratov Bureau of Forensic Medical Examination

The goal of the present paper was to find effective biochemical markers of chronic narcotization. Materials and methods. The results of biochemical research of biological liquids in human organism and chromatographic methods of drug substances identification in cadaveric urine were analyzed. Research of 197 samples of different biologic liquids of 10 persons was carried out. Control was fulfilled on the basis of 135 samples of biological liquids took of 12 persons. Methods of identification of drug substances are presented, chromatographic and spectral characteristics of drug substances are described. Interrelations of biochemical indices at positive study of drug substances identification were conducted. The increased urea metabolic concentration in cadaveric blood of drug addicts was revealed in comparison with control specimens. Results. (Numeral results are given in Table 3). Correct correlation of biochemical markers was not established. Conclusion. The present results suppose continued study of informative reliable biochemical markers of chronic drug intoxication

201103_642-646.pdf584.87 KB