Saratov JOURNAL of Medical and Scientific Research

Tikhonova L.A.

Saratov Road Clinical Hospital, Functional Diagnostics Physician, Candidate of Medical Science

Dynamic regulation of cerebral blood flow and it's clinical, and laboratory markers in elderly patients with arterial hypertension

Year: 2011, volume 7 Issue: №4 Pages: 842-845
Heading: Internal Diseases Article type: Original article
Authors: Malinova L.I., Sadjaya L.A., Tikhonova L.A.
Organization: Saratov Road Clinical Hospital, Saratov Institute of Cardiology, Russia
Summary:

Aim: to estimate the dynamic regulation of cerebral blood flow (CBF) and significance of clinical, and laboratory parameters as a possible markers of CBF violations. Material. 179 elderly patients with arterial hypertension were involved in the study. Transcranial Doppler ultrasonography (Philips Envisor HD, USA) was used for CBF parameters dynamics during orthostatic hypotension. Results. Main directions of CBF parameters changings (Friedman ANOVA p 0,0091 ... 0,012, coeff. of concordance 0,308 ... 0,691) were detected. Gender differences of CBF parameters, as well as blood pressure level influence upon CBF regulation during orthostatic hypertension were studied. Conclusion. Received data allow us to consider gender, controlled or uncontrolled hypertension, cytomorphological parameters of peripheral blood, diuretics usage as clinical, and laboratory markers of dynamic regulation of CBF in elderly patients with arterial hypertension

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Possibilities of magnetic resonance tomography in identification and diagnostics of neurosyphilis forms

Year: 2011, volume 7 Issue: №3 Pages: 647-652
Heading: Neurology Article type: Original article
Authors: Kolokolov O.V., Bakulev A.L., Zuev V.V., Sholomov I.I., Chekhonatskaya M.L, Kolesnikov A.I., Tikhonova LA., Starodubova A. V.
Organization: Saratov State Medical University
Summary:

Aim: To evaluate the possibilities of the magnetic resonance tomography (MRT) in diagnostics and identification of neurosyphilis. Materials and methods: A total of 1387 patients with different forms of documented neurosyphilis were examined to study the deficiency of neurological function. The diagnosis of neurosyphilis was confirmed by CSF-study. MRT was performed in 57 cases. Results: Magnetic resonance tomography (MRT) in 6 patients showed no pathology, 16 patients had arachnoid cystic changes and in 16 cases hydrocephaly occurred. Cerebral cortical atrophy was presented in 13 patients, in 12 cases — multifocal changes were visualized, 12 patients had white matter structural changes. Two cases required diagnostics. A 59-year-old man was hospitalized with epileptic seizure, progressive dementia and multifocal neurologic symptoms. A 40-year-old man was examined with recurring episodes of acute cere-brospinal accident and progressing cognitive disorders. Conclusion: MRT could be used in differential diagnostics of neurosyphilis imitating space-occupying lesions of cerebrum and spinal cord, tumors of central nervous system and could help to define the form of neurosyphilis

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Research results of application of reflexo-therapy in correction of myopia

Year: 2011, volume 7 Issue: №3 Pages: 624-628
Heading: Ophtalmology Article type: Original article
Authors: Agasarov L.G., Yurova O.V., Frantsuzov A.S., Tikhonova L.A.
Organization: Saratov Road Clinical Hospital, Russian Scientific Center of Restorative Medicine and Health Resort, First Moscow State Medical University n.a. I.M. Sechenov
Summary:

Objective: To develop the optimum scheme of acupuncture, aimed at improving the functional status of the visual analyzer in patients with myopia. Materials. Treatment was conducted in the main group by reflexology courses in 10 procedures and basic therapy in the control group, only basic therapy. The examination included the classic ophthal-mologic research methods, ultrasound and Doppler echoofthalmografy with color mapping of blood vessels — the ophthalmic artery (OA), central retinal artery (CRA) and posterior long ciliary arteries (ZDTSA), the study of visual efficiency and visual assessment of the subjective expression of asthenopia. The results of these studies were subjected to statistical analysis using the method of variation statistics with the computation of the arithmetic mean (M), the average error of the arithmetic mean (m) and the level of significance (p). Differences between mean values were considered significant if the probability of errors on the distribution of Student»s less than 0,05. The result showed a pronounced effect method of acupuncture on the clinical features, hemodynamic and ergonomic eye, the severity of visual fatigue and general condition of patients. Conclusion. The use of corporal-auricular acupuncture technique in patients with myopia allowed to increase the visual acuity without correction in 1,6 times, visual acuity with correction in 1,2 times, lower rates of subjective and objective refraction in an average of 29.8 and 32.4%, increase rates of accommodation of more than 1,5 times, to increase blood flow velocity characteristics in the GA by an average of 9.7, the CAC at 33.4 and ZDTSA by 27,5%. All this is possible to reduce the severity of subjective indicators of asthenopia in 58% of cases and to increase visual efficiency by 11,3%

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Age dependent dynamics of intima-media complex thickness in elderly patients with arterial hypertension

Year: 2011, volume 7 Issue: №3 Pages: 611-614
Heading: Internal Diseases Article type: Original article
Authors: Sadjaya L.A., Tikhonova LA., Malinova L.I.
Organization: Saratov Road Clinical Hospital, Saratov Institute of Cardiology, Russia
Summary:

Aim: To estimate the dynamics of intima-media complex in elderly patients with arterial hypertension. Materials: 179 elderly patients with arterial hypertension were involved in the study. Mean intima-media wall thickness (IMT) of common carotid arteries in plaque-free sites and prevalence of plaques were evaluated by B-mode ultrasound investigation (Philips Envisor HD, USA). Results: IMT changing was of nonlinear character, remained stable up to 74 years. Mean rate of the following IMT augmentation was 0.157 mm per year. Frequency of atherosclerotic plaque revealing was significantly increased since the 7th decade. Significant correlation between IMT and systolic, diastolic, mean blood pressure levels or medication spectrum was not revealed. Conclusion: Received data proved significant influence of aging upon IMT enlargement

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