Saratov JOURNAL of Medical and Scientific Research

immunoregulatory processes

Disturbances in system of cytokines and lipid exchange in patients with psoriasis

Year: 2011, volume 7 Issue: №2 Pages: 434-437
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Akhlupkina M.V., Svistunov A.A., Bakulev A.L, Zakharova N.B., Nikitina V.V.
Organization: Saratov State Medical University, First Moscow State Medical University n.a. I.M. Sechenov
Summary:

Investigation of proinflammatory and antiinflammatory cytokines content in blood serum (IL-1 (3, IL-4, IL-6, IL-8, IL-10, INF-y, IL-17) was carried out for establishment of clinical and diagnostic value of disturbances of immunoregulatory processes and lipid spectrum in patients with psoriasis. Method of solid phase immune-enzyme analysis and indicators of lipid profile on biochemical analyzer Stat Fax were used in the study. It was found out that psoriasis exacerbation was accompanied by change of proinflammatory and antiinflammatory cytokines in blood serum and increase of lipid profile level. The hyperproliferation and inflammatory skin changes in case of psoriasis exacerbation were accompanied by hyperproduction of cytokines and disturbance of immunoregulatory processes to Th-2 cellular answer including autoimmune processes. The described changes led to raised synthesis of lipids and to their entry into peripheral blood flow. Determination of proinflammatory cytokines and lipids level in blood serum in patients with psoriasis can be used for an estimation of severity of disease, its development prognosis and administered therapy

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