Saratov JOURNAL of Medical and Scientific Research

chronic kidney disease

Optimization of chronic kidney disease stages in patients with type 2 diabetes mellitus with the program "ChronicKidneyDiseaseDiagnostics"

Year: 2017, volume 13 Issue: №3 Pages: 484-488
Heading: Internal Diseases Article type: Original article
Authors: Yarkova N.A., Borovkov А.А., Soloviyanova E.N.
Organization: N. Novgorod State Medical Academy
Summary:

Objective: to evaluate the practical possibility of automated calculation of glomerular filtration rate (GFR) in patients with type 2 diabetes mellitus (DM) on the basis of the developed computer program «Chronic_Kidney_Disease_Di-agnostics». Material and Methods. The study included 233 patients (78 men and 155 women) with type 2 diabetes who were hospitalized in the Neuroendocrinological Department of Nizhny Novgorod Regional Clinical Hospital n.a. O. N. Semashko during the period from 2013 to 2016. The average age of patients was 57.75 years [52; 64]. According to the history the mean duration of type 2 diabetes was of 5.3 years [0.3; 8.0]. The average level of glycosylated hemoglobin (HbA1c) was 9.53% [7.0; 10.2]. All patients underwent clinical and laboratory an3 instrumental studies. The data obtained were entered into the program «Chronic_Kidney_Disease_Diagnostics» (authors: N.A. Yarkova, N.N. Borovkov, D.A. Terekhova). Statistical analysis of the results of research carried out by Statistica 7.0. Results. According to the study in patients with type 2 diabetes, chronic kidney disease has been identified in the pre-clinical stages C2 and C1 (56.2 and 25.8%, respectively). Conclusion. The program «Chronic_Kidney_Disease_Diagnostics» is intended for nephrologists, endocrinologists and therapists. It allows specialists to diagnose kidney CKD in patients in the therapeutic profile of the early preclinical stage. It is designed for quick calculation of glomerular filtration rate.

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Interdisciplinary conceptualization of palliative care for patients with chronic kidney diseases

Year: 2016, volume 12 Issue: №3 Pages: 412-414
Heading: Sociology of Medicine Article type: Author's opinion
Authors: Petrov G.S., Krom I.L., Yerugina N.N.
Organization: Saratov State Medical University
Summary:

The article presents the author's analysis of modern interpretations of palliative care. Transformation of palliative care conceptualization during the last decade has led to the appearance of a palliative approach to treatment of patients with chronic diseases; quality feature of this approach is possibility to render a palliative care along with treatment of underlying disease and syndrome treatment of a patient. The authors note that due to increasing number of patients requiring renal replacement therapy, organization of palliative care is relevant in the group of patients with chronic kidney diseases. According to the authors' viewpoint, palliative approach to aging and fast-growing cohort of dialysis patients, many of which are in the period of living out, suggests implementation of individual program of dialysis therapy, in domestic literature there are only a few works devoted to palliative approach to patients with terminal chronic renal failure that suggests prospects of research in this direction.

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. Chronic kidney disease in patients with chronic back pain taking non-steroidal anti-inflammatory drugs

Year: 2016, volume 12 Issue: №1 Pages: 40-44
Heading: Internal Diseases Article type: Original article
Authors: Gaydukova I.Z., Rebrov А.Р., Lebedinskaya О.А., Polyanskaya O.L., Patrikeeva D.A., Aparkina A.V.
Organization: Saratov State Medical University
Summary:

The aim of the study was to evaluate the incidence of chronic kidney disease (CKD) in patients with chronic back pain and nonsteroidal anti-inflammatory drugs (NSAIDs) intake not less than a year, and to study the interrelation between CKD, peculiarities of pain and its treatment. Material and Methods. 91 patients with axial spondyloarthri-tis — ax-SpA(ankylosing spondylitis and non-radiographic ax-SpA) and 35 patients with degenerative diseases of the spine (DDS) with NSADs intake not less than 1 year were involved in the study. The control group included healthy volunteers who did not took NSAIDs during the last year (n=51). By age, gender, factors of cardiovascular risk, GFR
in patients with ax-SpA, DDS and controls were comparable. The activity of pain was evaluated according to the accepted recommendations. The index of NSAID intake as calculated for the preceding year. Results. GFR in patients with ax-SpAwas 87,0 [77,25; 102,0] ml/min/1,73 m2, 11 (18%) patients showed a reduction in GFR of less than 60 ml/ min/1,73m2. In patients with DDS GFR was 87,5 [65,5; 97,0] ml/min / 1,73 m 2 (p=0,27), decreased GFR of less than 60 ml/min / 1,73 m2 was detected in 3 (15%) patients. The ratio of albumin / creatinine urine in patients with ax-SpA was 35,8 [25,46; 43,4] mg/g, in patients DDS —207,1 [91,66; 244,59] mg/g (p

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The senile kidney

Year: 2015, volume 11 Issue: №1 Pages: 046-049
Heading: Gerontology and geriatrics Article type: Lecture
Authors: Denisova Т.Р., Lipatova Т.Е., Chernenkov Yu.V., Nazarov M.l.
Organization: Regional Hospital for War Veterans, Saratov, Saratov State Medical University
Summary:

The given work summarizes external data and self-obtained results on development and diagnostic of kidney involution modifications. Article discusses definition of "senile kidney" as a clinical and pathomorphological term. Major statements on pathophysiological causes of age-associated renal disorders and their prognosis, specifics of chronic kidney disease in elderly and senile patients have been reviewed. Phenomenon of renal "multimorbidity" in eldely maximizes worsening risk of unmodifiable kidney function.

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Researching of cardos activity for chronic heart failure treatment in case of concomitant chronic kidney disease (stage V, conventional hemodialysis)

Year: 2011, volume 7 Issue: №2 Pages: 422-426
Heading: Internal Diseases Article type: Original article
Authors: Chepurina N.G., Kretov М.А.
Organization: Volgograd State Medical University
Summary:

Aim: comparative investigation of cardos (antibodies to angiotensin II receptor subtype 1 (AT.,) C-terminal fragment), diovan (Valsartan) or both drug combination effects (changing of clinical picture, physical exertion tolerance and quality of life) for treatment chronic heart failure (CHF) patients. Methods. 12-month open-label randomized research was performed. CHF patients (NYHA Class l-ll, n=30) with concomitant chronic kidney disease (stage V, conventional hemodialysis) were randomized (10 patients in each group) for 6-month treatment by cardos (group I, average dose 1,8g/day), diovan (group II, average dose 80mg/day)orboth drug combination (group III, cardos 1,8g/day and diovan 80mg/day). CHD basic treatment was prescribed for all patients. In a 6-month drug crossover between groups I and I was performed, group III was divided into 2 subgroups (subgroup IIIA— cardos, subgroup NIB — diovan) followed by next 6-month treatment. Results. Long-term treatment by cardos has improved functional class (NYHA) of CHF patients with concomitant chronic kidney disease (stage V, conventional hemodialysis). cardos, diovan and both drug combination have demonstrated improvement of physical exertion tolerance, quality of life and patient clinical status during 6-min walking test. Conclusion. Cardos and diovan have shown the same efficacy. Cardos can be used as real alternative in case of ARA administration necessity

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