Saratov JOURNAL of Medical and Scientific Research

Kobzeva U.A.

Saratov State Medical University n. a. V. I. Razumovsky, Associate Professor of Department of Propaedeutics of Dental Diseases, PhD

Evaluation of the efectiveness of psychopharmaco-therapy correction with an anxiolytic drug for patients with a periodontal disease and a dentopatiya.

Year: 2019, volume 15 Issue: №2 Pages: 256-260
Heading: Stomatology Article type: Original article
Authors: Savina E.A., Kobzeva Yu.A., Aslanyan M.A., Eremin O.V., Nelovko T.V.
Organization: Saratov State Medical University
Summary:

Objective: to assess the impact of behavioral psychotherapy and psychopharmacocorrection with an anxiolytic drug on the level of anxiety and dentophobia, compliance, and the efectiveness of therapy in patients with infamma-tory periodontal diseases. Material and Methods. Comprehensive examination of 40 patients aged 27–57 years with a diagnosis of refractory periodontitis. The clinical assessment of the periodontal tissues was taken into account and the psycho-emotional status of the patient was assessed using the characterological questionnaire H. Smishek, the hospital anxiety and depression scale and a specially designed questionnaire for determining the level of dentophobia and the dynamics of the doctor-patient relationship. Results. Since the frst visit and till the 26th week consecutive decrease in level of uneasiness, then slight increase by the 52nd week is noted. Conclusion. The use of the developed algorithm for personalized treatment of patients with infammatory periodontal diseases with the inclusion of behavioral psychotherapy and psychopharmacocorrection may reduce the level of anxiety and dental fear, increase compliance and the efectiveness of therapy.

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Clinical and laboratory substantiation of Mexidol use in complex treatment of periodontitis in patients with peptic ulcers

Year: 2011, volume 7 Issue: №2 Pages: 481-485
Heading: Stomatology Article type: Original article
Authors: Ostrovskaya L.U., Kobzeva U.A., Kharish N.A.
Organization: Saratov State Medical University
Summary:

To determine the clinical pathogenetic efficacy of Mexidol in the combined therapy of parodontitis in patients with peptic ulcers medical examination and treatment of 296 patients were carried out. Endoscopic, histological and im-munohistochemical studies were performed in all examined patients. Investigation of interleukin -6, -10, -18 in oral cavity by immunofermental analysis was conducted. It was established that Mexidol use in the combined treatment of patients with periodontitis and peptic ulcer allowed to decrease evidence of local inflammation, to normalize processes of neurohumoral and cytokine regulation, that provided acceleration of recovery processes, decrease in periodontitis recurrences. The statistical programs Exsel и Statistica 6.0 were used in the study. The subsequent analysis of the received data was carried out

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Application mexidol in treatment patients of inflammatory periodontal diseases in the combination to peptic ulcer of stomach and duodenal intestine

Year: 2011, volume 7 Issue: №1 Pages: 316-318
Heading: Stomatology Article type: Short message
Authors: Ostrovskaya L.U., Kobzeva U.A., Charish N.A., Mogila A.P.
Organization: Saratov State Medical University
Summary:

For the purpose to determine the clinical pathogenetic efficacy of Mexidol in the combined therapy of parodontitis in patients with peptic ulcer of stomach and duodenal intestine medical examination and treatment of 296 patients was carried out.
It was established that use of Mexidol in the combined treatment of patients with parodontitis against peptic ulcer of stomach and duodenal intestine allowed to decrease infection load (Helicobacter pylori) in parodontal recess and evidence of local inflammation with reduction of activity of interleukin-6, -10, -18, that provided acceleration of recovery processes, lowering in frequency of periodontitis recurrences

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Investigation of violations of the functional activity of platelets in patients with chronic generalized periodontitis with a view to early diagnosis of periodontal pathology

Year: 2011, volume 7 Issue: №1 Pages: 295-297
Heading: Stomatology Article type: Short message
Authors: Kitaeva V.N., Bulkina N.V., Polosukhina E.N., Parfenova S.V., Kobzeva U.A.
Organization: Saratov State Medical University
Summary:

Violations occurring in the microcirculatory bed of periodontal tissue, are leading in the development of periodontal disease. The greatest changes are detected at the level of capillaries - lowering the tone and elasticity of blood vessels, reducing blood flow and the development of periodontal tissue hypoxia as a consequence -the development of the state of hypercoagulability and increased thrombotic events in the periodontal vessels

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Experience of using immuno-therapy in treatment of chronic generalized periodontitis

Year: 2011, volume 7 Issue: №1 Pages: 280-281
Heading: Stomatology Article type: Short message
Authors: Bulkina N.V., Lukina L.V., Ostrovskaya L.U., Kobzeva U.A., Verechagina E.A.
Organization: Saratov State Medical University
Summary:

The application of immunomodulator Gepon in the treatment of chronic generalized periodontitis can improve the quality of care, reduce the time of preoperative preparation of up to 10 days (in the traditional treatment 14-16 days), rapid postoperative rehabilitation of patients and to achieve stable remission in 82% of patients with chronic periodontitis easy degree and 77% with moderate periodontitis after 6 months of observation

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