Saratov JOURNAL of Medical and Scientific Research

Kirichuk V.F.

Saratov State Medical University, Head of Department of Normal Physiology, Honoured Worker of Science, Professor, Doctor of Medical Science

Assessment of system's adaptive reserves by indicators of heart rate variability in young men at the initial stages of university education

Year: 2019, volume 15 Issue: №3 Pages: 796-800
Heading: Cardiology Article type: Original article
Authors: Olenko E.S., Fomina Е.М., Kirichuk V.F., Kodochigova A.l., Yupatov V.D., Konovalova A.A.
Organization: Saratov State Medical University
Summary:

The purpose of the study is to assess the activity index of regulatory systems and mechanisms of neurohumoral regulation of heart activity in healthy young men at the initial stage of university education. Material and Methods. We studied the activity index of regulatory systems (PARS) and features of the mechanisms of neurohumoral regulation of cardiac activity on a sample of 150 young men [19.0 (18.0; 19.0) years old], based on the analysis of heart rate variability. Results. 40.0% (n=60) of young men had a satisfactory state of adaptive reserves of the body, 23.3% (n=35) were in a state of low functional stress, 24.7% (n=37) had poor adaptation, and 12.0% (n=18) failed to adapt. Conclusion. In male students with satisfactory, tense, and unsatisfactory adaptation, as disadaptation increases, the total effect of all levels of regulation on the heart rate increases with an increase in the effect on the cardiac activity of the parasym-pathetic division of the ANS and a decrease in the activity of cerebral subcortical structures responsible for adaptation, against the background of an increase in psychoemotional stress. In healthy male students, the disruption of systems' adaptive reserves is often accompanied by the total decrease in all levels of regulation with a predominance of sympathetic influences on the heart rhythm and is less frequently associated with a sharp increase in all levels of regulation and the predominance of parasympathetic division of the ANS for the CVS.

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Distinctive features of psychological status for patients with various forms of coronary heart disease

Year: 2019, volume 15 Issue: №3 Pages: 744-749
Heading: Cardiology Article type: Original article
Authors: Kodochigova A.l., Kirichuk V.F., Sinkeev M.S., Bogdanova T.M., Olenko E.S., Filonenko E.V., Slyusarenko Yu.A., Dolgov A.A., Ilyin A.A.
Organization: Saratov State Medical University
Summary:

The purpose of the study is: to conduct comparative analysis of personal response characteristics in patients with stable and unstable forms of coronary heart disease, depending on the presence or absence of acute coronary disaster in their history. Materials and Methods. 94 men and women with an established diagnosis of coronary heart disease (CHD), aged 38 to 55 years were examined. All individuals under study were divided into 4 groups: two groups with stable forms of angina pectoris, and two groups with unstable angina pectoris, depending on the presence or absence of myocardial infarction history. The following tools were used to determine personal response characteristics in CHD patients: abbreviated multifactor personality questionnaire; Toronto alexithymic scale and psycho- geometric test. Re-sults. It was found that patients with coronary artery disease had a high level of neurotization, alexithymicity, conformity, pessimism, and low self-esteem, along with sociability, friendliness and desire to avoid conflict situations. Neurotic tendencies, alexithymicity and decreased activity were most pronounced in patients with history of acute coronary catastrophe (p<0.05). Conclusion. The results of the study determine advisability of including the methods of psychological correction of revealed changes in the complex of measures for secondary prevention of cardiovascular events in patients with various forms of coronary heart disease based on a personalized approach.

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Intense light deprivation as a factor in stress disorders of behavioral reactions and cognitive functions in the experiment

Year: 2019, volume 15 Issue: №2 Pages: 363-368
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Antipova O.N., Ivanov A.N., Zlobina O.V., Kirichuk V.F., Surovtseva K.A., Ankina V.D., Bondar G.D., Zenkina T.M., Polyukova M.V.
Organization: Saratov State Medical University
Summary:

Objective: to study the efect of light desynchronosis on behavioral reactions and cognitive functions of white male rats. Material and Methods. The study was conducted on 36 intact non-pedigree white male rats, which were divided into 2 groups: experimental and control. Animals were exposed to artifcial illumination 24 hours a day provided by the fuorescent lamp of 60 kW capacity. The same animals of the experimental group on the 10th, 21st and 30th days were tested in the installations «Dark-light camera» and «Open feld». Results. On the 10th day of intensive light deprivation, the indicators refecting the research-orientation activity reached the maximum values, which indicated the development of stress damage to the animal organism. On the 21st day of the experiment, the

Keywords: pneumocysts
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Individually-typological heterogeneity of prehypertension in young men

Year: 2016, volume 12 Issue: №3 Pages: 344-348
Heading: Cardiology Article type: Original article
Authors: Olenko E.S., Kodochigova A.l., Kirichuk V.F., Barylnik Yu.B., Trayber L.V.
Organization: Saratov State Medical University, «Psychiatric Hospital №13», Klin, Moscow Region
Summary:

Objective: to study the individually-typological features of the person of young men with prehypertension. Material and Methods. With the help of complex tests: Reduced Multiple Personality Questionnaire for research (MMPI), the Heck — Hess, Spielberger — Hanin, Index lifestyle were examined 95 healthy young men with different levels of blood pressure: optimal, normal and high normal. Results. It has been shown that people with normal and high normal blood pressure have different individually-typological features of the person and, based on this criterion can not be combined into a single group prehypertension. Men with normal blood pressure values on the studied parameters were similar to individuals with optimal blood pressure value. Persons with high normal level of blood pressure had a psychosomatic predisposition personality profile MMPI, with its fixation on physical sensations, with the increase of anxiety, neuroticism and the overall intensity of psychological protection. Conclusion. It is advisable to carry out a personalized approach to the psychological correction of identified changes in primary prevention of arterial hypertension in young men.

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Experience of terahertz therapy in benign prostatic hyperplasia combined with chronic abacterial prostatitis

Year: 2014, volume 10 Issue: №4 Pages: 649-654
Heading: Urology Article type: Original article
Authors: Popkov V.M., Kirichuk V.F., Loyko V.S., Maslyakova G.N., Blyumberg B.l.
Organization: Saratov State Medical University
Summary:

Objective: to improve the treatment results of patients with benign prostatic hyperplasia (stage l-ll) accompanied with chronic abacterial prostatitis (category III A) by the use of terahertz therapy at frequencies of molecular spectrum of emission and absorption of nitric oxide 150,176-150,664 GHz. Material and methods. Atotal number of 75 patients met the inclusion criteria and were available for analysis. They were divided into three groups: 1st core group — 25 patients with BPH (stage l-ll) accompanied with chronic abacterial prostatitis (category III), which received standard medical therapy in combination with THZ-therapy; second group — 25 patients with BPH (stage l-ll) accompanied with CAP, which received standard medical therapy; third control group — 25 healthy men. Results. The combination of THZ — therapy with standard medical treatment allowed us to achieve marked improvements in the IPSS and QoL system, rapid anesthetic effect, more significant volume reduction of the prostate tissue in the 1st core group. Also THZ-therapy in 1st core group revealed a statistically significant increase of the maximum speed of blood vessels in the prostate tissue, improved a prostate secretion and rheological properties of blood. Conclusion. THZ-therapy as a complementary treatment has a beneficial effect on the clinical course of BPH (stage l-ll) accompanied with CAP (category III).

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Effect of estrogen deficiency on the lipid profile in women in different age periods

Year: 2014, volume 10 Issue: №3 Pages: 396-400
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Neyfeld I.V., Rogozhina I.E., Kirichuk V.F., Kiselev A.R., Zhirnyakov A.l., Bobyleva I.V.
Organization: Saratov Institute of Cardiology, Russia, Saratov State Medical University
Summary:

The aim of the study is to evaluate influence of estrogen deficiency on lipid profile in women of different age. Material and Methods. 189 women with normal body weight: 44 women with premature menopause (aged <40 years), 69 women with early menopause (aged 40-45 years), and 76 women with natural menopause (aged 46-55 years) have been studied. In all women identification of clinical status has been performed during clinical examination. Results. It is shown that increasing age associated with increasing total cholesterol, triglycerides, low-density lipoprotein (LDL), very low density lipoproteins (VLDL) (p<0.05). We have not observed a significant association between age and level of high-density lipoprotein (HDL) (p=0.117). According with increased age, atherogenic index of plasma (AIP) increases from initial -0.17±0.09 (M±o) to 0.09±0.47 (p<0.05) in women with premature menopause, and to 0.14±0.21 (p<0.05) in other women. Final level of AIP was similar between women aged 40-45 years and women aged 46-55 years (p=0.084). Conclusion. Lipid metabolism disorders were assessed in 73.5% of women with estrogen deficiency. According to the age factor the rate of women with normal lipid metabolism decreases (x2=10,165, p=0.026).

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Psychophysiological features of male and female young patients with minor heart anomalies depending on degree of their intensity

Year: 2012, volume 8 Issue: №2 Pages: 209-213
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Kurako М.М., Kirichuk V.F., Kodochigova A.I., Papshitskaya N.Y., Olenko E.S., Sulkovskaya L.S.
Organization: Saratov State Medical University
Summary:

Research Objective: To compare the features of personal response in young patients with minor heart anomalies according to gender and severity of abnormalities. Materials and Methods: Physiological characteristics of 124 male and female (mean age — 22,16±2,42 years) have been examined by means of Toronto Alexithymic scale, reduced multifactorial questionnaire for the study of personality and psychogeometric test. Results: It has been found that both women and men with moderate degree of minor heart anomalies manifest polar intrapsychic tendencies, higher levels of alexithymia than in those with a lesser degree of dysplasia of the connective tissue of the heart. Conclusion: Patients with moderate degree of minor heart anomalies have experienced the conflicting intrapsychic tendencies and higher levels of alexithymia than patients with minor heart anomalies of a minimal degree, regardless of the gender. Male patients with varying degrees of severity are more likely to suffer from alexithymia than females

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Scientific and practical contribution of professor S.A. Georgieva to development of Russian physiology (dedicated to the 100-th Anniversary)

Year: 2011, volume 7 Issue: №4 Pages: 981-983
Heading: History of Medicine. Anniversary Dates Article type:
Authors: Kirichuk V.F., Zavyalov A.I., Tokaeva L.K., Babichenko N.E., Slezkina S.B.
Organization: Saratov State Medical University
Summary:

The article presents the most significant facts from biography of professor S.A. Georgieva. S.A. Georgieva made a great contribution by her scientific, pedagogical and public work to the development of Saratov medical institute. Her research work was directed to the study of hemostasis

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Stress depended changes in activityof gp red blood cells receptors and its correction by therahertz waves at nitric oxide frequency

Year: 2011, volume 7 Issue: №3 Pages: 583-586
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Kirichuk V.F., Svistunov S.V., Andronov E.V., Ivanov A.N.
Organization: Saratov State Medical University
Summary:

The effect of electromagnetic radiation in the terahertz range frequencies of molecular spectrum of emission and absorption of nitric oxide 150.176–150.664 GHz for the restoration of the impaired carbohydrate component and functional activity glikoproteid receptors of erythrocytes of white rats in a state of acute imm obilization stress. Shown that exposure to electromagnetic waves at these frequencies is the normalization of the increased content of b-D-galactose in the carbohydrate component and the restoration of the impaired activity of the receptors glikoproteid erythrocytes

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Study of nerve fibers nature reinforcing duodenal contractions by electrical stimulation of sympathetic nerve

Year: 2011, volume 7 Issue: №3 Pages: 580-583
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Sveshnikov D.S., Kirichuk V.F., Smirnov V.M., Myasnikov I. L, Kuchuk A.M., Trofimova J.E., Trubetskaya M.A.
Organization: Saratov State Medical University, Russian State Medical University
Summary:

The subject of the article is to investigate the mechanism of increased reactions by electrical stimulation of the sympathetic nerve. Materials and methods: Experiments on dogs have shown that stimulant reactions during blockade of a-adrenergic by phentolamine and (3-adrenergic receptors with propranolol were completely eliminated by lizer-gol —the blocker of 5-HT12-receptors. Results: Infusion of lizergol did not influence on duodenal motor activity and the function of the vagus nerve. Conclusion: Effector neuron is found out to be serotonergic and its action is provided by 5-HT1 2 receptors

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