Saratov JOURNAL of Medical and Scientific Research


Role of melatonin in pathogenesis of age-related macular degeneration

Year: 2019, volume 15 Issue: №2 Pages: 559-563
Heading: Ophtalmology Article type: Review
Authors: Khodzhaev N.S., Chuprov A.D., Kim S.M.
Organization: The S. Fyodorov Eye Microsurgery Federal State Institution

Age-related macular degeneration (AMD) is the leading cause of irreversible blindness in people aged 50 years and older in the advanced world. The article deals with the epidemiology and pathogenesis of the disease. Special attention is given to a new approach to the prevention and treatment of AMD with the help of melatonin; modern management options and scientifc achievements are discussed. Many researchers have shown that melatonin is able to protect retinal epithelial cells from oxidative damage. Perhaps the physiological reduction of melatonin in the elderly may be an important factor in the dysfunction of the retinal pigment epithelium, which is the cause of AMD.

2019_02-1_559-563.pdf285.23 KB

Tactics of delivery and diagnostic evaluation in pregnant women with peripheral vitreoretinal dystrophy

Year: 2019, volume 15 Issue: №2 Pages: 528-532
Heading: Ophtalmology Article type: Original article
Authors: Popova N.V., Goydin A.P., Fabrikantov O.L., Goydin D.A.
Organization: S. Fedorov Eye Microsurgery Federal State Institution, Tambov State University n. a. G.R. Derzhavin

Purpose: to develop recommendations on delivery tactics based on the analysis and terms of detection of various forms of peripheral vitreoretinal dystrophies in pregnant women with myopia. Material and Methods. 44 women were examined with a mean age of 31 years. Peripheral vitreochorioretinal dystrophy was detected in 82 %. All patients underwent the following studies: visometry using device TOPCON CV-5000 (Japan), autorefractometry using TOPCON KR-8900 (Japan), ultrasound biometry using TOMEY AL-3000 (Japan), eye fundus was examined by Goldman three-mirror lens using the slit lamp TAKAGI SM-70N. When severe peripheral vitreochorioretinal dystrophy is detected, it is recommended to perform peripheral laser coagulation using laser device IRIDEX IQ-810 (USA). Results. In most cases (68 %) peripheral retinal laser photocoagulation was performed with subsequent recommendations on the possibility of natural delivery, and in 32 % of cases caesarean section delivery was recommended to these women. Conclusion. Decision on delivery tactics in pregnant women with myopia should not be determined by the degree of myopia, but by the severity of pathological changes on the periphery of the retina. Medical examination of pregnant women with obligatory examination of the eye fundus with mydriasis medicamentosus in 30–34 weeks allows to identify patients at risk of retinal detachment and conduct early treatment, thereby initially reducing the frequency of operativedelivery according to the ophthalmological indications.

2019_02-1_528-532.pdf393.22 KB

Study of bioelectric brain activity and characteristics of heart activity in nystagmus suppressing by periodic light action


Results of research of bioelectric brain activity and heart rate activity of patients with eye nystagmus with simultaneous registration of nystagmograms, electroencephalograms and electrocardiograms are given. It is shown that at periodic influence of light on the eyes of patients the interconnected reduction of amplitudes of spectral components of electrocardiograms and electrocardiograms power spectra are observed

201101_097-102.pdf539.17 KB