Saratov JOURNAL of Medical and Scientific Research

Nikitina V.V.

Saratov State Medical University n.a. V.I. Razumovsky Department of Clinical Laboratory Diagnostics of Raising Skills Faculty, Assistant, Candidate of Medical Science

Contribution of professor V.I. Rubin to the development of clinical biochemistry

Year: 2020, volume 16 Issue: №2 Pages: 534-538
Heading: Scientific schools and memorable dates Article type:
Authors: Zakharova N.B., Borodulin V.В., Nikitina V.V., Bobyleva E.V., Ivanenko I.L., Kovalenko A.V., Gladilin G.P.
Organization: Saratov State Medical University
Summary:

The article presents the biographical data about Professor Vladimir Ivanovich Rubin, describing his academic contribution into the development of biochemistry and training of academic and pedagogical staff at the Saratov State Medical University.

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To live saving lives

Year: 2019, volume 15 Issue: №2 Pages: 392-395
Heading: Scientific schools and memorable dates Article type: Short message
Authors: Lazarenko Ya.S., Nikitina V.V.
Organization: Saratov State Medical University
Summary:

The article provides the data on the activity of the Saratov doctors at the front and in the rear during the Great Patriotic War and their contribution to the development of medicine, devotion of a profession and the sense of responsibility for people»s lives.

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The 40th anniversary of Department of Clinical Laboratory Diagnostics of Saratov State Medical University

Year: 2018, volume 14 Issue: №4 Pages: 696-699
Heading: Scientific schools and memorable dates Article type: Short message
Authors: Gladilin G.P., Zakharova N.B., Nikitina V.V., Ivanenko I.L.
Organization: Saratov State Medical University
Summary:

The article describes a brief history of the development of laboratory services and gives a modern idea of the importance of laboratory diagnostics in the clinic. The pedagogical, scientific activities and future prospects for the development of clinical laboratory diagnostics of the Saratov State Medical University are presented.

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Vascular endothelial growth factor as a risk predictor of thromboembolic complications in patients with orthopaedic profile

Year: 2016, volume 12 Issue: №3 Pages: 354-358
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Vorobeva I.S., Nikitina V.V., Gladilin G.P., Ivanenko I.L.
Organization: Saratov State Medical University
Summary:

Objective: to determine the risk of thromboembolic complications in orthopaedic patients. Material and methods. A survey of 151 patients who had undergone total endoprosthesis of large joints of the lower extremities, aged 25-68, under treatment in Saratov Scientific Research Institute of Orthopedics and Traumatology. Results. The performed research allowed to establish that at values of the content of VEGF-A to 183,6 PG/ml a low risk of thromboembolic complications was predicted and for values above 183,6 PG/ml high risk was prognosed. Conclusion. We have proved high efficiency of using the relationship of VEGF and PAI-1 in serum, which plays a leading role in the development of predisposition to thrombosis.

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Vascular endothelial growth factor as a risk predictor of thromboembolic complications in patients with orthopaedic profile

Year: 2016, volume 12 Issue: №3 Pages: 354-358
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Vorobeva I.S., Nikitina V.V., Gladilin G.P., Ivanenko I.L.
Organization: Saratov State Medical University
Summary:

Objective: to determine the risk of thromboembolic complications in orthopaedic patients. Material and methods. A survey of 151 patients who had undergone total endoprosthesis of large joints of the lower extremities, aged 25-68, under treatment in Saratov Scientific Research Institute of Orthopedics and Traumatology. Results. The performed research allowed to establish that at values of the content of VEGF-A to 183,6 PG/ml a low risk of thromboembolic complications was predicted and for values above 183,6 PG/ml high risk was prognosed. Conclusion. We have proved high efficiency of using the relationship of VEGF and PAI-1 in serum, which plays a leading role in the development of predisposition to thrombosis.

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Cytoprotective effect of cytoflavinum at treatment of thermal injury of various severity level

Year: 2012, volume 8 Issue: №1 Pages: 038-042
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Bozhedomov A.J., Morrison V.V., Shulaeva N.M., Nikitina V.V., Ivanenko I.L.
Organization: Saratov State Medical University, Saratov City Clinical Hospital №7
Summary:

The purpose of research was studying of cytoprotective effect of cytoflavinum at a thermal trauma of different severity level. Materials and methods. 169 patients with thermal burns with a favorable outcome and gravity of a thermal trauma from 30 to 170 points on Franc were under research. 28 patients took standard dosage of cytoflavinum while complex therapy. Results. Patients with thermal trauma more than 60 points on Franc took Cytoflavinumuse and demonstrated decrease in intensity of system inflammatory response syndrome (SIRS), reduction of band neutrophils portion, lowering of erythrocyte number, smaller activation ofthrombocytopoiesis, dicrease of concentration of vascular endothelial growth factor. Positive effect was not revealed in group of patients with thermal trauma less than 60 points who received cytoflavinum. Conclusion. Use of cytoflavinum was the most effective at thermal trauma gravity more than 60 points on Franc

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Disturbances in system of cytokines and lipid exchange in patients with psoriasis

Year: 2011, volume 7 Issue: №2 Pages: 434-437
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Akhlupkina M.V., Svistunov A.A., Bakulev A.L, Zakharova N.B., Nikitina V.V.
Organization: Saratov State Medical University, First Moscow State Medical University n.a. I.M. Sechenov
Summary:

Investigation of proinflammatory and antiinflammatory cytokines content in blood serum (IL-1 (3, IL-4, IL-6, IL-8, IL-10, INF-y, IL-17) was carried out for establishment of clinical and diagnostic value of disturbances of immunoregulatory processes and lipid spectrum in patients with psoriasis. Method of solid phase immune-enzyme analysis and indicators of lipid profile on biochemical analyzer Stat Fax were used in the study. It was found out that psoriasis exacerbation was accompanied by change of proinflammatory and antiinflammatory cytokines in blood serum and increase of lipid profile level. The hyperproliferation and inflammatory skin changes in case of psoriasis exacerbation were accompanied by hyperproduction of cytokines and disturbance of immunoregulatory processes to Th-2 cellular answer including autoimmune processes. The described changes led to raised synthesis of lipids and to their entry into peripheral blood flow. Determination of proinflammatory cytokines and lipids level in blood serum in patients with psoriasis can be used for an estimation of severity of disease, its development prognosis and administered therapy

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Value MCP-1 as predict vascular disturbances

Year: 2010, volume 6 Issue: №4 Pages: 786-790
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Nikitina V.V., Zaharova N.B.
Organization: Saratov State Medical University
Summary:

Vascular disturbances have been studying for more than 150 years. Nowadays vascular disorders cause many diseases. The article presents the significance of monocytic chemotactic protein-1 (MCP-1) and its function in athero-genesis. The data of the research are considered

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