Saratov JOURNAL of Medical and Scientific Research

pathomorphosis

Prognostic significance of the assessment of the expression of immunohistochemical markers and the degree of pathomorphism before and after treatment of patients with prostate cancer at high risk of progression

Year: 2019, volume 15 Issue: №2 Pages: 318-324
Heading: Urology Article type: Original article
Authors: Voronina E.S. , Fomkin R.N. , Bucharskaya A.B. , Palatova T.V. , Popkov V.M., Maslyakova G.N.
Organization: Saratov State Medical University
Summary:

Purpose: to analyze the expression of immunohistochemical markers in patients with prostate adenocarcinoma at high risk of progression before and after combined and combined treatment of patients with prostate specific antigen (PSA) level of blood below discriminatory. Material and methods. Examined patients (n = 80) with a diagnosis of “High-risk progression prostate cancer,” with clinical stage T3a, total score for Gleason scale from 8 to 10, the level of total PSA more than 20 ng / ml. Patients of the 1st group (n = 42) only combined surgical treatment in the scope of TUR and HIFU ablation the prostate; The 2nd group of patients (n = 38) additionally applied androgen deprivation in adjuvant mode. Results. Blood PSA, determined in patients after various methods of treatment is not always an objective indicator of its effectiveness. Immunohistochemical studies of tumor tissue for proliferative activity tumor cells, the activation of apoptosis in them, as well as the assessment of specific tumor markers and tumor suppressor genes showed that a decrease in the expression of these markers in patients with PSA values ​​of blood lower than discriminatory observed in all patients independently on the type of treatment. However, after treatment in the 1st group of patients, despite the achievement PSA level of nadir, there is a decrease in the expression of an intercellular adhesion marker E-cadherin, which indicates an increased risk of tumor metastasis, as well as increased expression of markers of the apoptosis inhibitor Bcl-2 and androgens, which indicates about the possibility of progression of tumor growth. Conclusion For a more accurate assessment therapeutic pathomorphism in patients with prostate cancer at high risk of progression, which HIFU ablation monotherapy was carried out, along with the determination of blood PSA level, it is necessary during the control biopsy of the prostate immunohistochemical studies of tumor tissue to determine the prognosis and risk of relapse.

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Manifestations of pathomorphosis at pregnant women with heart diseases

Year: 2017, volume 13 Issue: №2 Pages: 233-238
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Kazachkova E.A., Kazachkov E.L., Vorobiev I.V.
Organization: South Ural State Medical University
Summary:

Purpose: to study the structure of heart defects in pregnant women, the features of the medico-social portrait, the course of pregnancy and perinatal outcomes in patients with heart defects in the light of pathomorphosis. Material and Methods. A retrospective clinical and anamnestic analysis of the medical documentation of 165 patients delivered in the maternity hospital of the Municipal Health Care Institution of the City Clinical Hospital No. 6 in Chelyabinsk in 1991-1994 was conducted, (group 1)and a prospective cohort study of 168 patients who were delivered to this hospital between 2011 and 2014 (group 2) in accordance with a modified WHO classification for assessing the risk of cardiovascular complications for the mother and offspring, the characteristics of the medico-social portrait, The course of pregnancy and perinatal outcomes in patients with heart defects in the light of the doctrine of pathomorphosis. Results. It is established that over the past 20 years, there have been significant changes in the structure of heart diseases, the medical and social characteristics of patients with this disease, complications of gestation, which must be taken into account when choosing the optimal tactics for pregravid preparation, pregnancy in women with heart defects. Conclusion. The significant changes in the structure and frequency of heart defects observed in modern pregnant women with heart defects, in the features of the medical and social portrait of these patients, and also during pregnancy, childbirth and perinatal outcomes, can be treated as pathomorphosis in the clinical (narrow) sense.

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Pathomorphism in early forms of syphilis today

Year: 2012, volume 8 Issue: №2 Pages: 660-663
Heading: Skin Diseases Article type: Review
Authors: Utz S.R., Zavyalov A.I., Slesarenko N.A., Bakulev A.L.
Organization: Saratov State Medical University
Summary:

The article presents the analysis of literature data and own supervision concerning some changes in clinic of patients with early forms of syphilis.

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PATHOMORPHOSIS IN THE CLINICAL PICTURE OF NEUROSYPHILIS

Year: 2012, volume 8 Issue: №2 Pages: 463-469
Heading: Neurology Article type: Review
Authors: Kolokolova A.M., Kolokolov O.V., Abramova T.P.
Organization: Saratov State Medical University
Summary:

For the last decade the clinical fndings of the neurosyphilis had changed. We report a review of literature where the information about the modern picture of the disease is described.

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Neurosyphilis: problems of diagnostics and classification

Year: 2010, volume 6 Issue: №3 Pages: 632-636
Heading: Neurology Article type: Review
Authors: Kolokolov O.V., Sholomov I.I., Bakulev A.L., Kravchenya S.S., Kolokolova A.M.
Organization: Saratov State Medical University
Summary:

The study involved 1315 patients with various forms of syphilis. In 282 patients neurosyphilis was diagnosed. The detailed description of clinical picture of disease and the results of laboratory studies are given. Questions of tactics of medical examination, modern classification of neurosyphilis forms are discussed. The actions are discussed, allowing to increase probability of a favorable outcome of disease

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