Saratov JOURNAL of Medical and Scientific Research


Polyneuropathy: clinical polymorphism and the algorithms of diagnostics

Year: 2016, volume 12 Issue: №2 Pages: 292-296
Heading: Neurology Article type: Review
Authors: Sitkali I.V., Kolokolov O.V., Lukina E.V., Grigorieva E.A., Popova O.V.
Organization: Saratov State Medical University

The information about epidemiology and clinical polymorphism of neuropathies is summarized on the base of Russian and foreign literature. The algorithm of clinical observation in patients with polyneuropathy is presented.

2016_02-1_292-296.pdf318.19 KB

Retrocervical endometriosis: etiology, pathogenesis, classification, diagnosis and treatment

Year: 2016, volume 12 Issue: №2 Pages: 138-144
Heading: Obstetrics and Gynecology Article type: Review
Authors: Tarlamazian A.V., Stolyarova U.V.
Organization: Saratov State Medical University

The review deals with contemporary issues of etiology, pathogenesis, classification, diagnosis and treatment of retrocervical endometriosis on the basis of existing data in the literature on this disease. Among the various forms of endometrial disease incidence retrocervical endometriosis, according to various authors, is 30-34%. The process is characterized by the formation of deep infiltrative lesions, originating from the recto-vaginal septum, without capsules and clear boundaries, extensively localizing, affecting the adjacent organs with the formation of scar-adhesions and characterizing this pathology as a multi-disciplinary (gynecological, surgical, urological). There are many options etio-pathogenesis of retrocervical endometriosis, but none of them fully explains the diversity of forms of expression and localization of this pathology. Particular attention is paid to the influence of immune and hormonal factors on the development of the disease. It is noted that currently there is no single universally accepted by clinicians and morphology full classification of retrocervical endometriosis, and there are no generally accepted standards of its diagnosis. The variants of the treatment of this disease have been considered including hormonal and immunomodulatory therapies.

2016_02_138-144.pdf271.22 KB

The case of gonococcal pharyngitis in practice of dermatovenerologist


The article describes the clinical observation of atypical forms of gonococcal infection (isolated gonococcal pharyngitis in a men) and the complexity of its diagnostics.

2013-03_1-608-609.pdf206.91 KB

Prognosis and diagnostics for placental insufficiency according to markers of endothe-lial dysfunction, deciduation, apoptosis and cellular proliferation

Year: 2011, volume 7 Issue: №1 Pages: 052-059
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Lipatov I.S., Tezikov Yu.V.
Organization: Samara State Medical University

Objective. The research goal is to estimate prognostic and diagnostic possibilities of markers of endothelial dysfunction, deciduation, apoptosis and cellular proliferation concerning realization of placental insufficiency. Material. 154 women of high risk group of severe placental insufficiency development have been examined in dynamics of the second and third trimesters of pregnancy. 30 healthy pregnant women have made the control group. Research methods are clinical, immunological, instrumental. Results. It is established that prognosis and early diagnostics for severe placental insufficiency can be carried out with application of monitoring of the maintenance of endothelial dysfunction markers, placental fibers of a mother placenta membrane, apoptosis and cellular proliferation in blood. In the second trimester of pregnancy prognostically significant criteria have included an increase of an index of cytotoxicity of antien-dothelial antibodies, the general IgE, lymphocytes, expressing Fas/APO-1/CD 95-receptor, TNFb and decrease of FGP. Conclusion. Therefore the forms of realization and severity level of placental insufficiency have been caused by the beginning and degree of damages in adaptation of endothelial systems, activation of the immunopathological reactions in the placenta manifested by trophoblastoma programmed cellular destruction of lymphocytes

201101_052-059.pdf281.47 KB