Saratov JOURNAL of Medical and Scientific Research

Averyanov A.P.

Saratov State Medical University n.a. V.I. Razumovsky Department of Children's Diseases Propaedeutics, Endocrinology and Diabetology Assistant Professor, Doctor of Medical Science

Congenital megakaryoblastic leukemia: A clinical case

Year: 2019, volume 15 Issue: №1 Pages: 34-40
Heading: Pediatrics Article type: Case report
Authors: Nechaev V.N., Chernenkov Yu.V., Mishina O.A., Fedorova Yu.A., Averyanov A.P.
Organization: Clinical Perinatal Center of the Saratov Region, Saratov State Medical University

Leukemia in children (leukemia) is a systemic hemoblastosis, accompanied by a violation of bone marrow hemato- poiesis and replacement of normal blood cells with immature blast cells of the leukocyte series. Acute megakaryoblastic leukemia-one of the rarest forms of acute leukemia (1-3% of all leukaemias), which is characterized by the presence in the blood and bone marrow, along with undifferentiated blasts also megakaryoblasts, ugly megakaryocytes and platelet clusters. The work presents a clinical case of congenital acute megakaryoblastic leukemia in the child S., combined with the mosaic form of Down syndrome and a congenital heart defect.

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Medical students representations on socially significant aspects of influenza prevention

Year: 2018, volume 14 Issue: №4 Pages: 680-682
Heading: Sociology of Medicine Article type: Original article
Authors: Mikhailova E.V., Malugina T.N., Levin D.Yu., Averianov А.Р., Serdyukov A.Yu., Zheleznikov P.A.
Organization: Saratov State Medical University

The aim of the study is to assess the attitude to influenza prevention among medical students. Material and Methods. The survey of first-year students of Saratov State Medical University n.a. V. I. Razumovsky was conducted (n=110). Results included an analysis of the prevalence of different influenza prevention methods. We have identified the main causes of failures of specific influenza prevention and identified the most common ways of non-specific prevention. Conclusion. Despite the fact that the majority of students consider it necessary to carry out specific prevention of influenza, active immunization is used only by 15% of the surveyed students. Others prefer the methods of nonspecific prophylaxis of influenza.

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Cortisol level as a marker of adaptation processes in children with acute respiratory viral infections

Year: 2018, volume 14 Issue: №4 Pages: 646-650
Heading: Infectious Diseases Article type: Original article
Authors: Malyugina T.N., Malinina N.V., Averianov А.Р.
Organization: Saratov State Medical University

Aim: to study changes in the level of cortisol in children in the acute period of respiratory viral infection, depending on the etiology, severity of the disease and the presence and nature of the developed complications to establish an adaptation option. Material and Methods. 74 patients aged 1 to 10 years on day 1-3 from the beginning ofARVI (adeno-virus, parainfluenza, respiratory syncytial infection and mixed infection) and 15 healthy children were examined. The etiology ofARVI was established by PCR. Patients in the first three days from the beginning ofARVI were determined by the level of cortisol by the method, according to the indications, chest x-ray examination was performed. The type of adaptive response in children was determined by the value of the lymphocytic index and the level of cortisol in the blood serum. Results. The study showed that in children with ARVI there is a different reaction of the adrenal glands to the disease, which is characterized by both an increase and a decrease in their function. An increase in cortisol concentration characteristic of an adequate adaptation reaction was found in 59.2% of patients. In 12.3% of children noted a decrease in cortisol compared with the control group, in the remaining patients (28.5%) cortisol content did not differ from that in healthy children. Adaptation by the reaction type of "stress" alarm stage was observed in 37.1 % of children, the reaction of "stress" in the stage of resistance at 14.3% of patients, the reaction of "stress" with the development

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Perinatal lesions of the central nervous system in newborns according to the data of Clinical perinatal center of the Saratov region

Year: 2018, volume 14 Issue: №4 Pages: 639-645
Heading: Pediatrics Article type: Original article
Authors: Nechaev V.N., Chernenkov Yu.V., Averianov А.Р., Utts I.A.
Organization: Saratov State Medical University

The purpose was to analyze the risk factors for the development of perinatal lesions of the central nervous system and to identify cause-effect relationships. Material and Methods. The retrospective analysis of primary documentation: history of childbirth and history of development of newborns is carried out. The work is based on the results of a comprehensive clinical and neurological examination, neurosonographic data and individual laboratory parameters. Results. In 2017 in the clinical perinatal center of the Saratov region 3301 births were conducted, of which the first delivery was performed in 69,4%, repeated in 30,6% and cesarean section in 41,2% of women. Hypoxic-ischemic disorders were observed in 928 newborns (27,7%). Children with low Apgar score had a combined genesis of chronic intrauterine hypoxia and acute asphyxia in childbirth in 3.8% of cases. Intraventricular hemorrhages (IHD) were diagnosed in 4,3% of cases, birth injuries in 3,6%. Congenital malformations of the central nervous system (CNS) were detected in 31 children (24,4%). Conclusion. The pathological course of pregnancy, problematic natural childbirth and emergency cesarean section are the most frequent risk

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Radiation methods for evaluating renal function in children

Year: 2018, volume 14 Issue: №3 Pages: 385-388
Heading: Radiology Article type: Review
Authors: Chekhonatskaya M.L., Averianov А.Р., Uts I.A., Velikanova M.G., Bobylev D.A., Chekhonatsky I.A.
Organization: Clinical hospital n.a. S. R. Mirotvortsev SSMU, Russian Medical Academy of Postgraduate Education, Moscow, Saratov State Medical University

 An accurate assessment of renal function is critical for adequate dosing of medications. The most informative marker reflecting the functional state of the kidneys is glomerular filtration rate (GFR). Determination of inulin clearance is the most accurate way to assess GFR in children and adults. In this case, the method is invasive, cumbersome, younger children require the installation of a urinary catheter. Techniques for radioisotope estimation of GFR can solve this problem, but all widely used radioisotopes have the ability to bind slightly to plasma proteins, which leads to an underestimation of real values.

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Innovations in Medical Education: Results and Prospects

Year: 2013, volume 9 Issue: №1 Pages: 140-144
Heading: Pedagogics and Education Article type: Original article
Authors: Protopopov A.A., Averyanov А.P., Dorogoykin D.L., Suyetenkov D.Ye., Kloktunova N.A.
Organization: Saratov State Medical University

The aim of the article is to assess the situation with the introduction of innovative forms of education into medical higher schools. The levels of introduction and techniques of modernization of medical education have been presented. Having a complex of pre-university, secondary professional, undergraduate and graduate educational programs it has been shown that the State University organization has obtained a definite approach to the work in this sphere.

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State of cardiovascular system during exercise in sportsmen

Year: 2013, volume 9 Issue: №1 Pages: 64-68
Heading: Internal Diseases Article type: Original article
Authors: Usanov D.A., Protopopov А.А., SkripalA.V.,AveryanovA.P., Kashchavtsev Е.О.
Organization: Saratov State Medical University, Saratov state university

The purpose of the article is to study the state of cardiovascular system of sportsmen involved in rowing and canoeing, both before and after training. Material et methods: The research has been performed by means of the developed mobile devices that allow non-invasive screening assessment of the potential risk of collapse complications. Results: The article outlines the results of the survey carried out to determine the presence of vagotonic tone with deficient activity supply and abnormal pulse wave that may lead to circulatory collapse in exercise. Conclusion: The technique of pulse wave and vegetative regulation assessment before and after training enables to prevent the circulatory collapse development in stressful physical exertion in sportsmen.

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Methodological approach to complex educational and research works

Year: 2011, volume 7 Issue: №1 Pages: 162-165
Heading: Pedagogics and Education Article type: Author's opinion
Authors: Pantyukhin A.M., Protopopov А.А., Averyanov А.Р., Golikov A.G., Gorshkova N.V., Novokreshchenov I.N.
Organization: Saratov State Medical University

The important problem of higher professional education is preparation of specialists possessing skills in high technology equipment. Problem realization is directed to interdisciplinary educational research works and complex final qualifying works on for example working out of pharmaceutical preparations, biologically active additives to food and cosmetic means. The given work includes step-by-step decision of the problem put before students and it should be analogical relevant to dissertations on specialty «pharmacy». From the point of view of methodological approach concerning the choice of candidature and work theme the following categories of students according to their progress and type of personality are allocated: «stars», «fellow travelers» and «good students». On this basis various methodological approaches for work with «stars», «fellow travelers» and «good students» are considered in the article

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Diagnostics of evolution of risk collapse complications at student group with anomalous cardiovascular reaction

Year: 2010, volume 6 Issue: №3 Pages: 615-619
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Usanov D.A., Protopopov А.А., Skripal A.M, Averyanov A.P., Repin V.F., Rytik A.P., Vagarin A.Yu., Kuznetsov M.A., Petrova M.G.
Organization: Saratov National Research University n.a. N. G. Chernyshevsky, Saratov State Medical University

The description of investigation of predisposition to potential danger of collapse complications at 429 first-year students during physical training is presented using the analysis of pulse wave form. With the help of developed device the group of students with predisposition to risk of collapse complications during physical activity has been revealed. The results of clinical examination have confirmed the predisposition of the given group to risk of collapse complications

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