Saratov JOURNAL of Medical and Scientific Research

vaccination

Effects of the vaccine "Grippol" on resistance of mice after irradiation by protons

Year: 2015, volume 11 Issue: №4 Pages: 656-658
Heading: radiation medicine Article type: Short message
Authors: Ivanov А.А., Abrosimova A.N., Bulinina Т.М.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

Aim: to investigate the effect of the vaccine "Grippol" on radioresistance with respect to proton irradiation. Material and methods. The effect of the vaccine "Grippol" the survival of the animals was studied in mice CBAxC57BI F1, which was immunized for 10 days prior to proton irradiation. Results. It is shown that proton irradiation causes the death of the animals at all doses tested: 9% at a dose of 7.0 Gy; 10% — 8.0 Gy and 33% after irradiation at a dose of 8.5 Gy, at the same time the survival rate after pre vaccination study groups was 100%. It seems appropriate to further study the impact of the vaccine "Grippol" at low doses of proton irradiation using appropriate test evaluation of hematological, im-munological, genetic, physiological and other factors. Conclusion. The vaccine "Grippol" introduction into mice before lethal proton irradiation increases survival of protected animals.

CAT-test significance in life quality assessment in patients with chronic obstructive pulmonary disease

Year: 2010, volume 6 Issue: №3 Pages: 588-592
Heading: Internal Diseases Article type: Original article
Authors: Protasov A.D., Zhestkov A.M, Shanina I.Yu.
Organization: Samara State Medical University
Summary:

Comprehensive analysis of the impact of complex vaccination against pneumococcus, Haemophilus influenzae type b and influenza on performance CAT-test 6 months after vaccination in patients with chronic obstructive pulmonary disease compared with unvaccinated patients. 1 group - 48 patients with chronic obstructive pulmonary disease, vaccinated simultaneously «Pneumo-23», «Hiberix», «Grippol plus» (mean age - 61,46±1,17 years). Group 2-80 non-vaccinated patients with chronic obstructive pulmonary disease (mean age - 54,65±0,6 years). Patients from both groups held CAT-test at baseline and 6 months after. There was a significant decline in CAT-test after 6 months in the vaccinated patients compared with unvaccinated patients with chronic obstructive pulmonary disease.
CAT-test can be used as a sensitive tool to monitor indicators of quality of life in patients with chronic obstructive pulmonary disease in the process of therapy. Complete vaccination against pneumococcus, Haemophilus influenzae type b infection and influenza contributes to improving the quality of life in patients with chronic obstructive pulmonary disease in 6 months after medical intervention

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