Saratov JOURNAL of Medical and Scientific Research

cellular immunity

The characteristics of cellular element of immunity before and after endoprosthesis of large joints

Year: 2016, volume 12 Issue: №2 Pages: 182-185
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Mamonova I.A., Gladkova Е.М., Uljanov V.Yu., Babushkina I.V., Belova S.V., Puchinyan D.M., Kuzmin E.S., Bezrokov L.Kh.
Organization:
Summary:

The aim of the research is to study the indices of cellular immunity in patients before and after hip joint endoprosthesis. Materials and methods. The indices of cellular element of immunity (quantitative and qualitative composition of T-lymphocytes (CD3+), T-helpers (CD3+CD4+), cytotoxic T-lymphocytes (CD3+CD8+), B-lymphocytes (CD3-CD19+), natural killers (CD3-CD16+CD56)) in 20 patients with post-traumatic osteoarthrosis of III grade preoperatively and in the dynamic follow-up on the 3rd, 7th and 21st day post-surgically. Results. Patients with osteoarthrosis showed expressed immunological impairments both before and after endoprosthesis mostly affecting T-cellular immunity element and manifesting in immunoregulatory subpopulations imbalance as well as in T-suppressors decrement, T-helpers increment and NK-cells enlargement in patients after endoprosthesis. Conclusion. Patients with osteoarthrosis showed expressed immunological impairments both before and after joint endoprosthesis. Surgical intervention resulted in the aggravation of the pre-surgical disturbances in immunodeficiency.

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Markers of systemic inflammatory response in coxarthrosis

Year: 2013, volume 9 Issue: №4 Pages: 679-683
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Korshunov G.V., Shakhmartova S.G., Puchinyan D.M.
Organization:
Summary:

Objective: to detect markers of the systemic inflammatory response syndrome in patients with coxarthrosis by means of assessment of the status of the hemostasis system, endothelium function and inflammation intensity. Material and Methods. The indices of the plasmatic hemostasis, levels of VCAM-1, ICAM-1, ELAM-1, VEGF-A, neop-terin were analyzed. Results. It has been found that among the patients with hip coxarthrosis a group of patients (47%) with endothelium dysfunction, cellular immunity activation, a high content of Soluble Fibrin Monomer Complex and D-dimers and a group of patients (53%) without any abnormalities in these parameters should be differentiated. Conclusion. Among the patients with hip coxarthrosis a group with signs of a systemic inflammatory response syndrome (occurrence of endothelium dysfunction, cellular immunity activation, a high content of Soluble Fibrin Monomer Complex and D-dimers) and a group of patients with reference values of these parameters can be determined. The markers of the systemic inflammatory response syndrome in cases with hip osteoarthrosis are Soluble Fibrin Monomer Complex and D-dimers, high levels of intercellular adhesion molecule-1 (slCAM-1), vascular cell adhesion molecule-2 (sVCAM-1), cell adhesion E-selectin-1 (ELAM-1) and Neopterin (Np).

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Состояние фетоплацентарной системы у беременных с недифференцированными формами дисплазии соединительной ткани, носителей семейства герпес-вирусов

Year: 2010, volume 6 Issue: №3 Pages: 531-535
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Dorohova L.N., Shaboldin A.M., Narolenko L.N., Mozes V.G.
Organization: Kemerovo State Medical University, Kemerovo Clinical Hospital № 3 n.a. M.A. Podgorbunsky, Kemerovo Children Hospital № 5
Summary:

The research goal is to determine the risk of infectious process development in placenta of women with undifferenti-ated forms of dysplasia of connective tissue (UFDCT) by agents - herpes viruses (VHG - virus of herpes simplex and cytomegalovirus).
Persistent infection of VHG was revealed in 133 women in the 1 st trimester of pregnancy. All the patients had phe-notypic manifestations of UFDCT; in the 3d trimester of pregnancy immunogram of the second level, histological study of placenta, identification of antigens of VHG family, serological study of placental blood and isolation of DNA of VHG were carried out. All newborns were clinically and laboratory tested on VHG infection.
As pregnant women with UFDCT had high risk of VHG infection development in placenta, they suffered from placental insufficiency. It resulted in unfavourable perinatal outcomes. VHG infection development was caused by disturbances of cellular immunity.
Key words: undifferentiated forms of dysplasia of connective tissue, virus of herpes simplex, cytomegalovirus, cellular immunity, pregnancy

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