Saratov JOURNAL of Medical and Scientific Research

Perindopril

Pharmacodynamic and pharmacoeconomic aspects of application of antihypertensive preparations of various groups in patients with arterial hypertension

Year: 2010, volume 6 Issue: №3 Pages: 504-510
Heading: Clinical Pharmacology Article type: Original article
Authors: Kurkina T.V., Svistunov А.А., Bogoslovskaya S.I., Klochkov V.A., Glybochko G.H., Shuldyakov V.A., Luchinina EM., Levanov A.N.
Organization: Saratov State Medical University, Saratov Regional Hospital for Veterans of Wars, Saratov Institute of Cardiology, Russia
Summary:

At the background of the therapy for 3 months with Perindopril, Telmisartan and Bisoprolol, the patients with arterial hypertension were noted to decrease systolic and diastolic arterial pressure. The preparations under investigation had different effects on electrolyte metabolism. Therapy with Telmisartan turned out to have the least effect on electrolyte metabolism. Microalbuminuria is a risk factor in patients with arterial hypertension and may influence on the basic blood electrolyte balance. Bisoprolol should be recommended as the most preferable therapy for arterial hypertension from the pharmacoeconomic point of view. In order to control morning systolic arterial pressure the preference should be given to Perindopril, while for controlling evening systolic arterial pressure the preference should be given to Telmisartan

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