Saratov JOURNAL of Medical and Scientific Research

photodynamic therapy

Photodynamic therapy of psoriasis

Year: 2017, volume 13 Issue: №3 Pages: 678-681
Heading: Dermatovenerology Article type: Review
Authors: Utz S.R., Dobdina A.Ju., Talnikova Е.Е., Utz I.A.
Organization: Saratov State Medical University
Summary:

The review presents literature data on the use of photodynamic therapy in the treatment of psoriasis. In addition, the article discloses aspects of the mechanism of action, indications and contraindications, as well as the development of possible side effects when using this phototherapeutic technique.

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Nail psoriasis: the first experience of photodynamic curcumin therapy.

Year: 2017, volume 13 Issue: №3 Pages: 600-604
Heading: Dermatovenerology Article type: Original article
Authors: Utz S.R., Tal'nikova Е.Е., Sultanakhmedov E.S., Myasnikova T.D., Safonov V.A., Popovicheva O.A.
Organization: Saratov state university, Saratov State Medical University
Summary:

Aim: to determine the effectiveness of the photosensitizer "Curcumin" in various concentrations (0.15%, 1%, 1.5%) in combination with visible spectrum radiation in the treatment of nail psoriasis. Material and Methods. 6 patients (4 women and 2 men) of different age groups (from 20 to 50 years) with the established diagnosis of "Psoriasis" were observed. The study was carried out using the "Curcumin" photosensitizer solution, the broadband spectrometer "Ocean Optics USB4F01891", the LS-55 spectrometer, the PhotoDyn-750 and the THORLABS PM100D. To assess the dynamics of the pathological process, the N-NAIL Index was used. Results. The most pronounced and clinically significant changes were detected when using a 1.5% solution of the "Curcumin" photosensitizer. Conclusion. The photosensitive agent "Curcumin" is effective in photodynamic therapy of psoriasis of the nails.

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Curcumin usage in dermatology

Year: 2016, volume 12 Issue: №3 Pages: 484-487
Heading: Dermatovenerology Article type: Review
Authors: Utz S.R., Talnikova Е.Е.
Organization: Saratov State Medical University
Summary:

This review summarizes the literature, reflecting the use of curcumin in historic aspect, its physical and chemical properties, and also results of different researches to demonstrate the effectiveness of diferoylmethane in treatment of various diseases, particularly in treatment of skin diseases.

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Laser technologies in treatment of patients with secondary lymphostasis of lower extremities

Year: 2010, volume 6 Issue: №2 Pages: 462-464
Heading: Surgery Article type: Original article
Authors: B.N. Jukov, М.А. Melnikov
Organization: Samara State Medical University
Summary:

Photodynamic therapy (PDT), matured as a feasible medical technology in the 1980s at several institutions throughout the world, is a ternary treatment for cancer involving three key components: a photosensitizer, light, and tissue oxygen. It is also being investigated for treatment of psoriasis and acne, and is an approved treatment for wet macular degeneration. A photosensitizer is a chemical compound that can be excited by light of a specific wavelength. This excitation uses visible or near-infrared light. In photodynamic therapy, either a photosensitizer or the metabolic precursor of one is administered to the patient. The tissue to be treated is exposed to light suitable for exciting the photosensitizer. Usually, the photosensitizer is excited from a ground singlet state to an excited singlet state. It then undergoes intersys-tem crossing to a longer-lived excited triplet state. Singlet oxygen is a very aggressive chemical species and will very rapidly react with any nearby biomolecules

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