Saratov JOURNAL of Medical and Scientific Research

Original article

Lens densitometry in ultrasonic cataract phacoemulsification

Year: 2018, volume 14 Issue: №4 Pages: 815-817
Heading: Ophtalmology Article type: Original article
Authors: Aznabaev В.М., Dibaev T.l., Munasypova V/V., Khamidov U.B., Mukhamadeeva O.R.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

Purpose: to evaluate the effectiveness of using Pentacam HR sheimpflug camera for objective determination of cataract density. Material and Methods. The subject of the study was the method of determining the density of the lens (densitometry) by the Pentacam HR sheimpflug-camera. The object of the study were patients with age-related cataracts (147 eyes). All patients underwent ultrasound phacoemulsification with implantation of various types of intraocular lenses (IOL). Before treatment, the density of the lens was determined by non-contact method using PNS (Pentacam Nucleus Staging). During the surgery, the density of the lens was determined by the surgeon on a set of factors: the color of the nucleus, the mechanical density, the emulsification easiness. The equivalent ultrasound time and the fact of compliance or discrepancy in the degree of density of the lens with two methods of its determination were recorded for each patient. Results. It was found that the density of the lens recorded by the Pentacam HR is in a direct strong correlation with the equivalent ultrasound time. It was shown that the discrepancy between the PNS method and the contact method performed by the surgeon significantly lengthens the surgery time. Conclusion. The Pentacam HR sheimpflug-camera is an accurate method of determining the density of the cataract before the surgery. The advantage of this method is that it is non-contact, quick and relatively easy-to-perform with the possibility of objective assessment.

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Clinical performance of system for ultrasonic cortex aspiration during phacoemulsification

Year: 2018, volume 14 Issue: №4 Pages: 811-815
Heading: Ophtalmology Article type: Original article
Authors: Aznabaev В.М., Dibaev T.I., Mukhamadeev T.R., Idrisova G.M.
Organization: Bashkir State Medical University of the Russian Health Care, ZAO Optimedservis
Summary:

Purpose: to study the performance and safety of the use of system for cortex aspiration with the possibility of additional dosed low power ultrasound during phacoemulsification. Material and Methods. The comparative evaluation of developed system for cortex aspiration with the possibility of additional dosed low power ultrasound (main group, n=36, ophthalmological surgical platform Optimed Profi) and the traditional system for cortex aspiration (control group, n=40, ophthalmological surgical platform Centurion Vision System) were performed. Results. Using the system for cortex aspiration decreases mean time of cortex aspiration. In the main group the mean time of cortex aspiration was 72.6±24.3 s, in the control group 93.9±48.0 s (p<0.05). Intraoperative complications were not observed in the main group. Posterior capsule rupture was detected during the cortex aspiration in 1 patient (2.5%) in the control group. Conclusion. The system for cortex aspiration with the possibility of additional dosed low power ultrasound allows decrease the time of cortex aspiration, to create conditions for a safer removal of cortex, compared with traditional technology.

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Clinical efficacy of using autocytokines in surgery for bullous keratopathy

Year: 2018, volume 14 Issue: №4 Pages: 805-808
Heading: Ophtalmology Article type: Original article
Authors: Denisko M.S., Krivosheina O.I.
Organization: Grand Retina LTD, Siberian State Medical University
Summary:

Purpose: to study clinical efficacy of a surgical modality of treatment for bullous keratopathy (BK), which is based on cell technology and involves intrastromal injection of autologous mononuclear leukocytes suspension, in comparison with medical therapy. Material and Methods. All patients with BK in this study were divided into two groups: treatment group, which consisted of 14 subjects who underwent intrastromal injection of autologous mononuclear leukocyte suspension; and control group, which included 13 subjects who received conservative treatment. Results. In treatment group corneal edema significantly subsided 1 month after treatment, which was accompanied by a decrease in corneal thickness by 24% and a 3.4-fold increase in visual acuity. After 6 months pachymetry index decreased by 32.8% from the initial value, visual acuity increased 10-fold from the initial value as well, and these parameters remained stable for 8 months. In control group, biomicroscopic pattern and pachymetry index had unstable dynamics, which was accompanied by only a 2.7-fold maximum increase in visometry after 1 month with a gradual decrease observed later on. Conclusion. Our method of surgical treatment for BK which involves injection of suspension of autologous mononuclear leukocytes into a posterior third of corneal stroma leads to a faster relief of corneal syndrome symptoms, restoration of normal corneal thickness within reference values and to a significant and stable increase in visual acuity when compared to a course of medical treatment.

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Correction of the dry eye syndrome of professional etiology using a complex of mitochondrial substrates and co-factors

Year: 2018, volume 14 Issue: №4 Pages: 799-804
Heading: Ophtalmology Article type: Original article
Authors: Anisimova S.G., Mazina N.K., Abramova T.V.
Organization: Kirov Regional Clinical Hospital, Kirov State Medical University
Summary:

Aim: to evaluate the effect of the drug Cytoflavin (CFL), containing mitochondrial substrates and co- factors, on tear production in arc welders, gas welders and office workers with dry eye syndrome (DES). Material and Methods. 124 patients (248 eyes) with DES of professional etiology were enrolled in this study. Patients of the experimental group (CFL) took three 25-day courses of cytoflavin separated by 1 month intervals, while the control group received placebo. Results. Reception of CFL over 3-month cycles with intervals of 30 days contributed to an increase in visual acuity (VA) by 29,0-34,0%, Schirmer's test (ST) by 27.0-51.0%, and Norn's test (NT) by 7.5-11.0%, meniscus measurements (MM) by 32.0-37.0% and lower indices of intraocular pressure (IOP) by 3-5% in both occupational groups. Conclusion. The resulting increase in values of parameters characterizing the functional activity of the lacrimal gland under the action of the CFL suggest that pharmacological energy protection contributes to the improvement of tear production and eye hydrodynamics in welders and office workers.

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Modern domestic cosmetics in combined treatment of scalp conditions

Year: 2018, volume 14 Issue: №4 Pages: 769-773
Heading: Dermatovenerology Article type: Original article
Authors: Shnaider D.A., Guskova O.P., Gorbenko A.V., Ivanov S.D.
Organization: Saratov State Medical University
Summary:

Objective: to evaluate effectiveness, safety and feasibility of using modern domestic ASD-containing liposomal cosmetics (all type shampoo and balm for dry scalp) in combined treatment of psoriasis patients with scalp involvement. Material and Methods. Sixty three patients (35 women and 28 men) with disseminated guttate-plaque psoriasis with scalp involvement were observed in Saratov Regional Clinical Dermatovenerologic Dispensary. The disease was in the stage of progression in all patients. All type shampoo and balm for dry scalp were included in the treatment regimen of all patients, while no other topical preparations were used on the scalp. Results. We observed good therapeutic and cosmetic effect in all patients, who encountered noside effects during the use of ASD-containing liposomal cosmetics. Conclusion. Combined scalp skin care with the use of modern domestic ASD-containing cosmetics will help doctor and patient to achieve the optimal result in treatment of psoriasis with scalp involvement, effectively eliminating main symptoms of the disease in a shorter time, improving patients' quality of life and giving them opportunity to lead normal life and feel comfortable in society.

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Psoriasis onset risk assessment in persons with hereditary predisposition with age, stress level and eating behavior taken into account

Year: 2018, volume 14 Issue: №4 Pages: 751-754
Heading: Dermatovenerology Article type: Original article
Authors: Shnaider D.A.
Organization: Saratov State Medical University
Summary:

Purpose: to analyze the significance of stress levels and psychology of eating behavior in people with hereditary predisposition for psoriasis for assessment of psoriasis manifestation risk in the next three years. Material and Methods. Two hundred eighty seven people aged 21-63 years with newly diagnosed psoriasis were investigated. All patients were surveyed using Holmes — Rahe Stress Inventory to assess their stress levels and Dutch Eating Behavior Questionnaire to determine the type of their eating behavior. Results. It has been established that external and emotional eating behavior in people with hereditary predisposition to psoriasis is an unfavorable prognostic factor for manifestation of dermatosis at an earlier age. Conclusion. In persons with hereditary burden index over 0.6 units psoriasis can manifest with stress level below 150 points, as determined by Holmes — Rahe questionnaire, while in persons with a hereditary burden index below 0.2 units disease manifestation is largely associated with a stress level over 300 points.

The effect of medical and social factors on compliance to prevention recommendations in psoriasis patients

Year: 2018, volume 14 Issue: №4 Pages: 748-751
Heading: Dermatovenerology Article type: Original article
Authors: Shnaider D.A., Bakulev A.L.
Organization: Saratov State Medical University
Summary:

Purpose: to evaluate the effect of medical and social factors on compliance to recommendations for prevention of psoriasis in affected patients. Material and Methods. Two hundred eighteen patients aged 22-43 years with 1 to 10 years from the onset of psoriasis were observed for one year. Patients were surveyed to evaluate their willingness to follow the recommendations for prevention of disease exacerbations after a detailed explanation of these preventive measures. Results. It has been established that men living in rural areas, having a family and with more than 5 years since the onset of psoriasis belong to a social group which has a tendency to ignore most recommendations for prevention of psoriasis. Conclusion. A regression analysis has demonstrated a relationship between degree of compliance to doctor's recommendations for prevention of exacerbations and their annual frequency.

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The combined method of applying chitosan-con-taining hydrogel together with radiofrequency lifting

Year: 2018, volume 14 Issue: №4 Pages: 744-747
Heading: Dermatovenerology Article type: Original article
Authors: Galkina Е.М., /Utz S.R./ Kondrateva А.А., Karakaeva A.V., Artemenko S.A.
Organization: Saratov State Medical University
Summary:

Purpose: evaluation of Pelleve™ method ("Surgitron DF S5" device) effectiveness when combined with application of chitosan-based hydrogel. Material and Methods. A study of cosmetic chitosan-based hydrogel in combination with radiofrequency lifting in a group of patients consisting of 18 people aged 30 to 60 years. Results. With chitosan-containing hydrogel applied to the skin before the procedure of radiofrequency lifting, the skin is heated more quickly which effectively reduces working time of the electrode. Conclusion. The technical outcome of the study is an increased efficiency of radio wave lifting achieved through the use of chitosan-containing hydrogel.

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The effect of botulinum toxin type A injections on production of sebum in seborrhea

Year: 2018, volume 14 Issue: №4 Pages: 740-744
Heading: Dermatovenerology Article type: Original article
Authors: Kondrateva А.А., Galkina Е.М., Karakaeva A.V., Morrison A.V., Morrison V.V.
Organization: Saratov State Medical University
Summary:

 Aim: assessment of sebum production dynamics in patients who received treatment for mimic and static wrinkles in glabella and forehead regions with phase of a menstrual cycle taken into account. Material and Methods. We observed 15 female patients aged 24-38 years who received botulinum toxin therapy. Each BTX-Avial contained 100 units of lyophilized preparation. The solution of BTX-Awas prepared by mixing it with 2 ml of sterile saline. Five intramuscular injections with 2 U of BTX-A per point were made across the forehead, while 3 U injections were done in the glabellar area. The total amount of botulinum toxin used was 19 U per patient. Results. Maximum decrease in sebum production was observed 4 weeks after botulinum toxin injections, and return to baseline was observed at 16 weeks of follow-up. Conclusion. According to the obtained data, it may be stated that botulinum toxin injections affect sebum production with a maximum decrease observed at 4 weeks after botulinum toxin therapy.

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Antiangiogenic properties of beta-blockers

Year: 2018, volume 14 Issue: №4 Pages: 728-734
Heading: Dermatovenerology Article type: Original article
Authors: Dubensky VI.V, Dubensky V.V.
Organization: Tver State Medical University of the Ministry of Russia
Summary:

 Objective: determination of comparative antiangiogenic effectiveness and influence of beta-blockers on the level of a vascular endothelial factor of growth in an experiment. Material and Methods. For determination of antiangiogenic effect of beta-blockers, comparative studying of their influence on the level of a vascular endothelial factor of growth in an experiment on 72 nonlinear laboratory rats, by average weight 180±20 g which were conditionally divided into 6 groups is executed: 1st — control, 2nd — negative control (experimental ischemia (El), crossing of femoral vessels), 3rd — positive control (El with bevacizumab introduction), 4th — El with introduction of a timolol, 5th — El with introduction of a betaksolol, 6th — El with introduction of interferon alpha 2b. Results. The VEGF levels were: in 1st group 1.5±0.3 pg/ ml, in 2nd group 20,3±3,2 pg/ml, in 3rd group5,8±0,9 pg/ml, in 4th group 13,8±1,4 pg/ml, in 5th group 192,0±2,3 pg/ml, in 6th group 11,1 ±2,2 pg/ml. Results of microscopy and immunohistochemical research demonstrate lack of activation of processes of neoangiogenesis in 1 st group of animals. At animals of 2nd and 5th groups along with the expressed inflammatory processes the neoangiogenesis phenomena are established. Conclusion: Beta-blockers show the direct or mediated negative impact on synthesis of VEGF and oppression of neoangiogenesis. The activity of selective beta-blocker concerning neoangiogenesis suppression was lower in comparison by activity non-selective that allows to consider the timolol effective antiangiogenic remedy.

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