Saratov JOURNAL of Medical and Scientific Research

Original article

The use of innovational computed method of color vision testing in clinical practice

Year: 2018, volume 14 Issue: №4 Pages: 913-916
Heading: Ophtalmology Article type: Original article
Authors: Bilalov E.N., Ziyoviddinov М.К., Bilalov B.E.
Organization: Tashkent Medical Academy
Summary:

The aim of study: to test created method of computed investigation of color vision with «TM A Computed color test» soft system. Materials and Methods. There was conducted comparative analysis of efficiency of computer program with conventional Rabkin's plates. Testing was conducted during entrance committee of Tashkent medical academy. During this period 3000 entrants were examined. Results. Measuring of basic physical color characteristic's shown that color characteristic's of monitor screen during test in «TMA Computed color test» are almost similar to those in Rabkin's plates, among 3000 entrants there were diagnosed 96 patients with color anomalies. Conclusion. It shown, that created method has a high efficiency in revealing of color anomalies during mass medical examinations and could be used in clinical practice.

Light-induced total electrical activity of retina in models of particular disorders in vivo and in vitro

Year: 2018, volume 14 Issue: №4 Pages: 903-909
Heading: Ophtalmology Article type: Original article
Authors: Mukhamadeev T.R., Ahmadeev R.R.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

Aim: to conduct an electrophysiological study of functional state of retina under the influence of ophthalmological surgical and typical pathogenic factors on various experimental models. Material and Methods. Experimental registration of electroretinogram (ERG) and total receptor potential (TRP) in vivo and in vitro under influence of various pathogenic factors. Results. It was shown that there is a slight decrease in the amplitude of the ERG in the early postoperative period after vitreoretinal surgery in rabbits followed by almost complete restoration of the electroretinogram to its original values. Registration of electrical activity of isolated retina of amphibians showed a rapid inhibition of a-, b- and d-waves of ERG during anoxia and their recovery during re-oxygenation. TRP inhibition during anoxia is developed more slowly than ERG inhibition, but its recovery does not occur during re-oxygenation. Preparations of isolated retinas with preserved pigment epithelium were much more resistant to oxygen deficiency. The results are discussed from a neurophysiological point of view and are consistent with the paradigm of retinal remodeling in experimental pathology with the leading role of neural mechanisms. Conclusion. The most adequate and effective methodological approach to assess the impact of typical and specific pathogenetic factors on the overall functional state of the retina is to register the total electrical activity of the retina in models in vivo. Studies of more subtle changes at the receptor, neuronal and interneuronal levels under the influence of various extreme factors on the retina are more expedient to carry out on in vitro models with registration of both total and local activity.

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Ретроспективный анализ биометрических характеристик и локализации увеальной меланомы по данным ультразвукового дуплексного сканирования орбиты

Year: 2018, volume 14 Issue: №4 Pages: 900-902
Heading: Ophtalmology Article type: Original article
Authors: Азнабаев Б.М., Александров А.А., Ишбулатова A.M.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

Цель: провести ретроспективный анализ биометрических характеристик и локализации увеальной меланомы по данным ультразвукового дуплексного сканирования орбиты. Материал и методы. В Центре лазерного восстановления зрения «Оптимед» г. Уфы за 2017-2018 гг. исследованы 22 пациента с объемным образованием сосудистой оболочки глаза — меланомой. Соотношение больных мужчин и женщин 1:1 (11 мужчин и 11 женщин). Возраст обследованных пациентов варьировался от 46 до 89 лет. Результаты. По данным проведенных ультразвуковых дуплексных сканирований орбиты чаще отмечалась парамакулярная локализация опухоли (72,2%). Высота проминенции объемных образований в среднем составила 7,6±4,6 мм, ширина основания 10,1±4,1 мм. У 20 пациентов (90,9%) определялся кровоток над объемным образованием. В 54,5% случаев наблюдалась вторичная отслойка сетчатки. Заключение. Ультразвуковое дуплексное сканирование орбиты является информативным неинвазивным инструментально-диагностическим методом, позволяющим выявлять увеальную меланому на ранней стадии.

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Comparison of uveal melanoma molecular classification systems

Year: 2018, volume 14 Issue: №4 Pages: 898-890
Heading: Ophtalmology Article type: Original article
Authors: Yarovoy А.А., Yarovaya V.A., Chudakova L.V., Chochaeva A.M., Loginov R.A., Kleyankina S.S., Zaretsky A.R.
Organization: Evrogen Laboratory LLC, The S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Purpose: to compare cytogenetic and mutational classifications of uveal melanoma (UM) in comprehensive analysis. Material and Methods. UM tissue from 154 eyes treated by enucleation or eye-sparing treatment was analyzed. Analysis included FISH for monosomy 3 and 8q gain, PCR for GNAQ, GNA11, EIF1AX and SF3B1 mutations and immunohistochemistry for BAP1. The group of 66 patients was used to compare cytogenetic and mutational classifications of uveal melanoma. Results. Discrepancy between cytogenetic and mutational classifications was revealed in 79% of cases. Unusual combination of EIF1 AX mutation with monosomy 3 or BAP1 inactivation was seen. Conclusion. Prognostic significance of the discrepancy between the two UM classifications is currently unknown. Further research is needed.

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Analysis of the structure of oncological diseases of the eye, ad-nexa and orbit (according to the data of 2nd ophthalmological department of the Orenburg Regional Clinical Hospital No.1)

Year: 2018, volume 14 Issue: №4 Pages: 894-897
Heading: Ophtalmology Article type: Original article
Authors: Aprelev А.Е., Abdulgazizova Z.F., Zakirova I.I., Aprelev А.А.
Organization: Orenburg State Medical University
Summary:

Purpose: to analyze incidence of neoplasms of the eye, ocular adnexa and orbit of the inhabitants of the Orenburg region in 2017 Material and Methods. The article presents an analysis of archival material from 123 case histories in patients with neoplasms of the eye and its adnexal apparatus, who were treated in 2nd Ophthalmology Department of the State Budgetary Health Institution "OOKB No.1". The case histories were analyzed consecutively. Results. Data on the prevalence (63.4%) of malignant neoplasms of the eye in women of retirement age were obtained. According to pathology, eyelid basalioma was most common — 67.3% followed by choroid melanoma — 23.6%. The localization frequency of neoplasms is as follows: malignant neoplasm of the conjunctiva 4.4%, benign neoplasm of the conjunctiva 12.9%, malignant neoplasms of the eyelid skin, including eyelids commissure 56.5%, benign neoplasms of the eyelid skin, including eyelids commissure 31.5%, choroid malignant neoplasms 30.4%, benign choroid neoplasms 3.7%, benign neoplasms of cornea 9.3%, malignant orbital tumors 8.7%, benign tumors of the orbit 42.6%. Conclusion. Women of retirement age need to be screened for malignant eye tumors.

Keywords: adnexa, eye, oncology, orbit
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Results of combined treatment of iris cysts

Year: 2018, volume 14 Issue: №4 Pages: 891-894
Heading: Ophtalmology Article type: Original article
Authors: Yarovoy А.А., Bulgakova E.S., Yarovaya V.A., Chochaeva A.M., Korobov E.N.
Organization: The S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Purpose. To present the own experience in iris cyst treatment. Materials and Methods. In this retrospective study 20 eyes with iris cysts were included. Lesions were managed with intracystic ethanol irrigation with and without subsequent surgical resection of the walls. Results. Complete iris cyst destruction was achieved in 16 cases. In 4 eyes cyst recurrence after ethanol irrigation was revealed and successfully treated by ethanol irrigation without subsequent surgical resection of the walls. No complications were seen within mean follow-up of 26 months. Conclusion. Intracystic ethanol irrigation is an effective treatment modality. Additional surgical resection of the cyst walls helps to improve treatment results with no signs of recurrences and complications.

Results of treatment of optic neuritis

Year: 2018, volume 14 Issue: №4 Pages: 875-879
Heading: Ophtalmology Article type: Original article
Authors: Latypova Е.А.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

Purpose: to investigate the epidemiological and clinical features of optic neuritis, evaluate the effectiveness of treatment and underlying diseases. Material and Methods. 58 patients (60 eyes) with optic neuritis (ON) were observed. Among them, 54 adults (26 men, 28 women) aged 19-67 years (mean age 36±11.8 years) and 4 children (1 boy, 3 girls) 14-16 years. Along with the standard ophthalmologic examination, electrophysiological studies, visual evoked potentials and magnetic resonance imaging of the brain and orbit, and a consultation with a neurologist were conducted. The patients were divided into two groups. In the main group of 32 patients (34 eyes), the complex treatment is carried out according to the developed method, which includes daily administration of 1 % nicotinic acid solution in the age dose (from 1 ml to 6 ml per day) with pentoxifylline on the background of basic ON therapy. In the control group of 26 patients (26 eyes), along with basic therapy of 1% nicotinic acid, 1 ml intramuscularly is prescribed a course of 10-15 days. Results. The number of children of young working age (65.5%), including children (6.9%). In the overwhelming number of cases, intrabulbar neuritis was diagnosed (84.5%). In 8 of 9 patients, the precursor of retrobulbar neuritis (PN) was multiple sclerosis (MS). Among other etiological causes of ON viral infection prevailed (37.9%). In patients prolonged by the proposed method, an improvement in visual functions (increased visual acuity, expansion of the general boundaries of the visual field) was achieved in 91% of cases, including high vision (0.5-1.0) in 65% of cases; in patients of the control group, these indicators correspond to 54% and 23%. Conclusion. The use of nicotinic acid intravenously in age dosage with pentoxifyllone in complexes with basic therapy allows the use of methods of treatment of optical neuritis using etiology and can be recommended for widespread use in practical ophthalmology.

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Surgical treatment of regmatogenous retinal detachment complicated by macular hole using platelet-rich blood plasma and local staining

Year: 2018, volume 14 Issue: №4 Pages: 867-870
Heading: Ophtalmology Article type: Original article
Authors: Zaharov V.D., Shkvorchenko D.O., Krupina E.A., Kakunina S.A., Norman K.S., Khurdaeva A.G., Yukhananova A.V.
Organization: The S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Purpose: to study the effectiveness of surgical treatment of regmatogenous retinal detachment (ROS) complicated by macular hole (MH) using platelet-rich blood plasma (PRP). Material and Methods. The study included 27 patients (27 eyes) with a diagnosis of ROS complicated by MH. In each case, the technique was used, namely, that after performing vitrectomy, a perfluororganic compound (PFOS) was injected into the hole area with a diameter of 2-3 diameter of the disk, to prevent penetration of dye under the retina, stained and removed internal limiting membrane (ILM). After serial PFOS/air replacement at the gap introduced PRP. The operation was completed with the introduction of silicone oil (CM). CM was removed from the vitreous cavity after 2 months. The follow-up period is 12 months. Results. In all cases, it was possible to achieve the adhesion of the retina and block Mr. During the observation period visual acuity increased to 0.1-0.9. Conclusion. According to the evaluation of the results, surgical treatment of regmatogenous retinal detachment complicated by MH using PRP is an effective method of treatment.

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Surgical treatment of regmatogenous retinal detachment complicated by macular hole using platelet-rich blood plasma and local staining

Year: 2018, volume 14 Issue: №4 Pages: 867-870
Heading: Ophtalmology Article type: Original article
Authors: Zaharov V.D., Shkvorchenko D.O., Krupina E.A., Kakunina S.A., Norman K.S., Khurdaeva A.G., Yukhananova A.V.
Organization: The S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Purpose: to study the effectiveness of surgical treatment of regmatogenous retinal detachment (ROS) complicated by macular hole (MH) using platelet-rich blood plasma (PRP). Material and Methods. The study included 27 patients (27 eyes) with a diagnosis of ROS complicated by MH. In each case, the technique was used, namely, that after performing vitrectomy, a perfluororganic compound (PFOS) was injected into the hole area with a diameter of 2-3 diameter of the disk, to prevent penetration of dye under the retina, stained and removed internal limiting membrane (ILM). After serial PFOS/air replacement at the gap introduced PRP. The operation was completed with the introduction of silicone oil (CM). CM was removed from the vitreous cavity after 2 months. The follow-up period is 12 months. Results. In all cases, it was possible to achieve the adhesion of the retina and block Mr. During the observation period visual acuity increased to 0.1-0.9. Conclusion. According to the evaluation of the results, surgical treatment of regmatogenous retinal detachment complicated by MH using PRP is an effective method of treatment.

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Evidence of the safe period intravitreal tamponade by perfluorodecalin in clinical practice

Year: 2018, volume 14 Issue: №4 Pages: 862-866
Heading: Ophtalmology Article type: Original article
Authors: Arslanov G.M., Aznabaev В.М., Mukhamadeev T.R., Dibaev T.I.
Organization: Saratov State Medical University, The Eye Clinic «Zrenie» (Saint Petersburg)
Summary:

 Purpose: to perform clinical testing of perfluorocarbon liquid on the basis of perfluorodecalin with the possibility of intravitreal postoperative tamponade in patients with vitreoretinal pathology and explain the effectiveness of this practice. Material and Methods. Were evaluated anatomical and clinical results of vitrectomy with PFCL intravitreal tamponade in 105 (113 eyes) patients with severe vitreoretinal pathology. Three observation groups were distinguished: group I (in-traoperative and postoperative intravitreal tamponade by perfluorodecalin, national sample); group II (only intraopera-tive use of perfluorodecalin, foreign sample); group III (only intraoperative use of perfluoro-1.3- dimethylcyclohexane). Results. Retinal attachment in the group of patients with postoperative intravitreal tamponade was 97.1% (visual acuity increased in 71.5% cases). All cases of failure or redetachment, postoperative complications and cataract progression did not have a statistically significant association with postoperative intravitreal tamponade as risk factor (x2=0,316; X2=0,068; x2=0.061; x2=0.403, p>0.05). Conclusion. Clinical testing of perfluorocarbon liquid intravitreal tamponade on the basis of perfluorodecalin in patients with vitreoretinal pathology showed high anatomical and clinical results with a high probability of retinal attachment.

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