Saratov JOURNAL of Medical and Scientific Research

Original article

ENDOTOXICOSIS PROBLEM IN OBSTETRIC-GYNECOLOGIC PRACTICE

Year: 2009, volume 5 Issue: №1 Pages: 56-59
Heading: Obstetrics and Gynecology Article type: Original article
Authors: A.N. Chudaikin, M.A. Levina, S.L. Peshev, S.V. Ermolaeva, O.A. Kuzmina, R.Kh. Salekh
Organization: Mordovian State University
Summary:

The level of endogenous intoxication has been studied in 444 patients: with inflammation of uterine appendages (98), dysfunctional uterine bleeding (123); in pregnant women with hypertensive disease (107), with chronic tonsillitis (116). It has been established that the level of endotoxemia depends on nosologic type of pathology. Blood catalase activity may be considered as a universal sign of endogenous intoxication.

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200901_056_059.pdf203.88 KB

DYNAMICS OF BIOCHEMICAL PARAMETERS OF BLOOD SERUM AT GESTOSIS

Year: 2009, volume 5 Issue: №1 Pages: 54-56
Heading: Obstetrics and Gynecology Article type: Original article
Authors: N.R. Ermakova
Organization: Saratov State Medical University
Summary:

Dynamics inspection of pregnant women with gestosis, including analysis of biochemical parameters is carried out. Change of metabolic concentration and activity of enzymes in blood serum depending on gestosis course is revealed. Opportunities of estimation of the given parameters for early gestosis diagnostics are determined.

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200901_054_056.pdf172.41 KB

PATHOGENETIC SIGNIFICANCE OF GROWTH FACTORS IN THE GESTOSIS DEVELOPMENT (CLINICAL RESEARCH)

Year: 2009, volume 5 Issue: №1 Pages: 51-54
Heading: Obstetrics and Gynecology Article type: Original article
Authors: L.U. Davidyan, E.N. Malanina, R.M. Khairullin, A.U. Bogdasarov, V.A. Selifonov
Organization: Ulyanovsk State University
Summary:

The decrease of epidermal and transformative growth factors in the process of gestation indicates the deficient development of fetopiacental complex and can be used as a prognosis criterion of the gestosis development from the beginning of pregnancy.

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200901_051_054.pdf183.33 KB

PECULIARITIES OF CHANGES ОF IMMUNOREGULATORY SYSTEM OF WOMEN WITH BACKGROUNG PATHOLOGY OF UTERINE CERVIX (NA)

Year: 2009, volume 5 Issue: №1 Pages: 49-51
Heading: Obstetrics and Gynecology Article type: Original article
Authors: S.N. Gribova, G.I. Khripunova, N.B. Zakharova
Organization: Saratov State Medical University
Summary:

A comparative research of cytokines IL-1b, IL-4, IL-6, IL-8, INF-/, TNF-a and its concentration in cellular material suspension on surface of pseudo erosion of uterine cervix was carried out. It was clarified that inefficient activation of local protective factors of immune system plays the main role in clinical behavior of pseudo erosion of uterine cervix. Imbalance of cytokines output to pro-inflammatory factors was observed.

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200901_049_051.pdf194.2 KB

SOME ASPECTS OF ORGANIZATION OF HIGH TECHNOLOGY MEDICAL AID RENDERING AT SARATOV SCIENTIFIC RESEARCH INSTITUTE OF TRAUMATOLOGY AND ORTHOPEDICS

Year: 2009, volume 5 Issue: №1 Pages: 45-48
Heading: Health Service Organization Article type: Original article
Authors: I.A. Norkin, V.V. Savchenko, T. N. Akimova, S.P. Ilinykh, E.V. Gladkova, M.A. Saakjan, A.S. Kolmykova, T.A. Shulgina
Organization: Saratov Scientific Research Institute of Traumatology and Orthopedics
Summary:

The article is devoted to the peculiarities of organization of high technology medical aid rendering at Saratov Scientific Research Institute of Traumatology and Orthopedics. Profiles and volumes of high technology medical aid and its order during 2006-2007 are presented.

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200901_045_048.pdf203.54 KB

BETA-ADRENORECEPTORS GENETIC POLYMORPHISM CONNECTION WITH BETA-BLOKER THERAPY EFFICACY IN PATIENTS WITH CARDIOVASCULAR DISORDERS

Year: 2009, volume 5 Issue: №1 Pages: 41-44
Heading: Clinical Pharmacology Article type: Original article
Authors: A.N. Levanov, I.V. Ignatyev, D.A. Sychev, S.I. Bogoslovskaya, A.A. Svistunov
Organization: Saratov State Medical University, First Moscow State Medical University n.a. I.M. Sechenov, Institute of Clinical Pharmacology
Summary:

At present it is obvious that genetic peculiarities of patients are the major reason for individual differences in pharmacological responses to (?-adrenoblockers. Furthermore ADRB1 gene polymorphism is responsible for the efficiency of (?-adrenoblockers. Thus, a real prospect exists for an individualized approach to administration of (?-adrenoblockers and selection of dosage based on patient’s genotype, which must undoubtedly increase efficiency of the administered therapy. Reviewfocuses on gene polymorphism responsible for (?-adrenoblockers pharmacodynamics and on the clinical significance of the polymorphism detection to individualize drug therapy based on patient’s genotype.

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200901_041_044.pdf207.86 KB

HISTOFUNCTION TRANSFORMATION IN ENDOCRINE AND IMMUNE ORGANS UNDER VARIOUS REGIMEN INFLUENCE OF ELECTROMAGNETIC RADIATION

Year: 2009, volume 5 Issue: №1 Pages: 36-40
Heading: Macro- and Micromorphology Article type: Original article
Authors: E.B. Rodzaevskaya, J.V. Polina, I.A. Uvarova, V.D. Tupikin, L.I. Naumova, N.V. Bogomolova, M.O. Kurtukova, O.V. ZIobina
Organization: Saratov State Medical University, Astrakhan State Medical University
Summary:

The effects of resonance and no-resonance of the low-intensify EMW frequency regimes were examined in Vistar rats,males. The microscopic structures and histochemical changes in thyroid, thymus,adrenals,ovaries,and other organs were studied. Our researchers evidenced, that the resonance EMW frequency regime slightly stimulates cell mitotic activity and exchange of substances in organ’s parenchyma and micro-circulation in connective tissue stroma. Treatment the course of no-resonance frequency EMW regime deteriorates the ratio between parenchyma and mesenchyme components correlation is detected in organ.

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200901_036_040.pdf434.88 KB

MORPHOFUNCTIONAL INDICES AND RISK FACTORS OF CARDIOVASCULAR HEART DISEASES AT STUDENTS’ HEALTH EVALUATION

Year: 2009, volume 5 Issue: №1 Pages: 31-36
Heading: Macro- and Micromorphology Article type: Original article
Authors: A.V. Lobacheva, V.N. Nikolenko, A.A. Svistunov, S.L. Bieber
Organization: University of Wyoming, USA, Saratov State Medical University
Summary:

This article contains the results of examination of morphofunctional parameters; determination of somatotypes; identification of cardiovascular diseases’ risk factors, and evaluation of health condition of students -all of which can be used for the development of personalized health preservation programs.

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200901_031_036.pdf278.87 KB

ACTIVITY OF CANONICAL WNT SIGNAL SYSTEM IN HYALINE CARTILAGE ARTICULAR CHONDROCYTES IN PROCESS OF SYNOVIAL JOINT DEVELOPMENT

Year: 2009, volume 5 Issue: №1 Pages: 26-31
Heading: Macro- and Micromorphology Article type: Original article
Authors: S.L. Kuznetsov, A.O. Molotkov
Organization: First Moscow State Medical University n.a. I.M. Sechenov
Summary:

Canonical and non-canonical Wnt systems are essential regulators of chondrogenesis and bone development. However, the roles of these systems in synovial joint development are not well studied. To determine if canonical Wnt system is active in developing articular chondrocytes we used immunohistochemistry for в-galactosidase and doublecortin (cell-type specific marker for articular chondrocytes) to double label sections through joint regions of E14.5, E18.5, P10 and adult mice. Here the following results are presented. Canonical Wnt signal system does not
work in developing articular chondrocytes at early embryonic stages (E14.5); it is active in the articular chondrocytes at late embryonic stages (E16.5-E18.5) and during postnatal development (P7-P10), but is turned off again in the adult articular chondrocytes. These results suggest that canonical Wnt signaling is being regulated during articular chondrocytes differentiation and joint formation.

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200901_026_031.pdf283.98 KB

SUMMARY SECTION CHANGES OF SUBEPICARDIAL ARTERIAL CHANNEL IN PEOPLE OF OLD AGE

Year: 2009, volume 5 Issue: №1 Pages: 24-26
Heading: Macro- and Micromorphology Article type: Original article
Authors: A.A. Korobkeev, O.A. Buzarova
Organization: Stavropol State Medical University
Summary:

The dynamics of summary section changes of different levels of coronary arteries branching in people of old age within different variations of the coronary arteries bifurcation has been under the study.
The research results in the determination of the summary section changes of coronary vessels and their connection with both topography, and the variations of their branching.

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200901_024_026.pdf216.4 KB