Saratov JOURNAL of Medical and Scientific Research

chronic generalized periodontitis

Sexual dimorphism of dynamics of concentration of endothelium alteration factors in blood in surgical treatment of chronic generalized periodontitis.

Summary:

Aim: to study the sexual dimorphism of the concentration in the blood of endothelial alteration factors in the dynamics of the surgical treatment of moderate chronic generalized periodontitis (CGP) in comparison with clinically healthy volunteers. Material and Methods. A total of 20 clinically healthy volunteers (average age is 30 (24; 37), 50% are men) and 31 patients with moderate chronic generalized periodontitis (average age is 31 (27; 38), 40% are men) were examined. Serum concentrations of homocysteine and C-reactive protein were determined. Patients with chronic generalized periodontitis were treated following the surgical scheme. Results. In patients with chronic generalized periodontitis, prior to treatment, an increased level of homocysteine and C-reactive protein (CRP) was detected in the serum. Conservative treatment in the preoperative period caused a decrease in the level of homocysteine in patients, while there was no significant change in the rate of C-reactive protein. 10 days after the surgery, an increase in the concentration of homocysteine and C-reactive protein in serum was observed in patients of both sexes, indicating a reactive change. At the same time, reactive changes were more pronounced in women. Long-term results of surgical treatment of chronic generalized periodontitis indicate a decrease in C-reactive protein and homocysteine levels in patients of both sexes. Sexual dimorphism was manifested by the fact that women had lower homocysteine content than men: 9.4 (8.9; 9.7) versus 13.3 (10.8; 14.1) umol/l (p=0,004). Conclusion. Patients of both sexes with moderate chronic generalized periodontitis have elevated C-reactive protein and homocysteine levels. Sexual dimorphism is manifested by higher levels of homocysteine, but not C- reactive protein in men. The acute period of surgical treatment of chronic generalized periodontitis is characterized by an increase in the concentration of factors affecting the endothelium in the blood, which are more pronounced in women. Long-term surgical treatment results of chronic generalized periodontitis demonstrate a decrease of homocysteine and C-reactive protein levels in blood with homocysteine levels being lower in women than in men.

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2018_3-1_579-583.pdf288.49 KB

Posmetnaya TV. Peculiarities of clinical and X-ray findings at women during postmenopause with chronic generalized periodontitis determined by mineral bone density

Year: 2016, volume 12 Issue: №4 Pages: 586-588
Heading: Stomatology Article type: Original article
Authors: Eremina N.V., Ismailova О.А., Strukov V.I., Kirillova T.V.,
Organization: Penza Institute for Advanced Training of Physicians
Summary:

The aim: to study clinical and X-ray specifics of chronic generalized periodontitis of women during a postmenopaus-al period determined by mineral bone density. Material and Methods. 80 women having chronic generalized periodontitis during a postmenopausal period were examined using clinical and X-ray research. Material of bone density was taken into consideration. Results. Decrease of hygienic indices of women at postmenopausal period has been found. It depends on the degree of severity of chronic generalized periodontitis. There was a reverse connection of periodon-tal index and mineral density of bone tissues in the 1-st group: — 0.9 (p<0.05), in the 2-nd group: — 0.5 (p<0.05), in the 3-rd group: — 0.79 (p<0.05). Cone-beam computer tomography made possible to find out the initial signs of edge osteoporosis of interdental partitions at the light degree of chronic generalized periodontitis and signs of spot and homogenous osteoporosis of gum bones, osteoporosis of interdental partitions with osteolysis at mild and severe degrees of severity. Conclusion. The clinical researches with cone-beam computer tomography and densitometry have revealed the exact data on the condition of bone tissues. The results have given an opportunity to plan osteotropic therapy and to control the dynamics of the process correctly.

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Gender features of rheological properties of blood (plasma viscosity, aggregation and deformation of erythrocytes) in patients with chronic generalized periodontitis

Year: 2014, volume 10 Issue: №1 Pages: 56-61
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Kazantsev A.V., Suyetenkov D.Ye.,/Andronoy E.V./, J Firsova I.V.
Organization: Saratov State Medical University
Summary:

The goal is to study gender features of rheological properties of blood in patients with chronic generalized periodontitis (CGP) from mild to moderate severity. Material and Methods. 80 patients (43.8% male) with CGP aged 42±5 years have been studied. 41 patients (43.9% male) experienced mild severity of CGP, and 39 patients (43.6% male) experienced moderate severity. 40 healthy adults (50% male), aged 31±7 years, have been included into the study. Plasma viscosity on shear rate values 300 sec1 to 5 sec1, and rheological features of erythrocytes (aggregation and deformation) have been evaluated. Results. In healthy women and women with mild severity of CGP, plasma viscosity was lower than in the similar group of men. The rheological features of erythrocytes have not gender differences among healthy adults and patients with mild CGP. Increased severity of CGP has been associated with increased plasma viscosity and rheological features of erythrocytes, particularly in men. Conclusion. Plasma viscosity differs in men and women (childbearing age) (healthy subjects and patients with CGP). In women, severity of pathological changes of plasma viscosity and rheological features of erythrocytes have been determined to be lower than in men.

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2014_01_56-61.pdf291.63 KB

Chronic oral pathology and ischemic heart disease and its complications

Year: 2013, volume 9 Issue: №3 Pages: 408-412
Heading: Stomatology Article type: Original article
Authors: Ivaschenko Y.Y., Shvarts Y.G., Parkhonyuk E.V., Eremin O.V.
Organization: Saratov State Medical University
Summary:

Objective: to establish the relationship of chronic generalized periodontitis, multiple cavities and dentofacial anomalies with various forms of coronary heart disease and its complications. Material and methods. The study included 294 patients with coronary heart disease and its complications. The patients were divided into two groups. Group I included 89 patients with acute Q-myocardial infarction, which was placed in the presence of at least 2 of the following criteria identified on the basis of a comprehensive clinical and instrumental examination: clinical, laboratory confirmation (CK-MB), electrocardiographic signs of damage or myocardial necrosis. The following statistical methods were used: multi-variate and univariate analysis of variance, non-parametric tests, crosstabulation, chi-square test, Fisher»s exact test. As a measure of variability of the normal distribution standard deviation was used. Results. It is noted that in patients with myocardial infarction more likely than in patients without coronary heart attack in history severe generalized periodontitis, dentofacial anomalies and multiple dental caries have appeared. In patients with acute myocardial infarction, severe periodontal disease has been associated with increased fibrinogen levels in the blood and an increase in the dispersion of the interval QT, which are known to be indicators of poor prognosis in acute coronary disease.

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Risk factors of development of inflammatory diseases of parodentium in pregnant women

Year: 2013, volume 9 Issue: №3 Pages: 383-386
Heading: Stomatology Article type: Original article
Authors: Dubrovskaya M.V., Eremin O.V., Savina Е.А., Ivashchenko Y.Y., Minasyn A.M.
Organization: Saratov State Medical University
Summary:

Pathogenesis of oral hygiene, smoking, gestosis, immunosuppression and cytokine disbalance affect inflammatory periodontal diseases in pregnant women. The research goal is to study clinical and immunological features of parodentium and cytokine profile in oral cavity of pregnant women. Material and methods: The condition of parodentium tissues was studied at 240 women with physiological pregnancy and 360 with pregnancy complicadet by gestosis. Re-sults: Freguency and character of inflammatory periodontal diseases in pregnancy were defined. Immune and cytokine disbalance contributed greatly to pathogenesis of inflammatory periodontal diseases at pregnant women. Conclusion: Violations of immune homeostasis at the pregnancy, complicated gestosis, authentically are more expressed that contributes to the development of gingivitis and periodontal disease. The imbalance of cytokines can serve in oral liquid as additional diagnostic and predictive marker of severity of a course of inflammatory periodontal disease.

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Changes in the trigeminal nerve under the infuence of cortexin in patients with chronic generalized periodontitis

Year: 2012, volume 8 Issue: №2 Pages: 481-484
Heading: Neurology Article type: Original article
Authors: Lepilin A.V., Sholomov I.I., Erokina N.L., Soyher M.G., Nozdrina V.D., Bisultanov H.W.
Organization: Saratov State Medical University, Center for Interdisciplinary Dentistry and Neurology, Moscow
Summary:

Purpose: correction of violations in the trigeminal nerve in patients with chronic generalized periodontitis. Material and methods. A clinical examination and study of the functional activity of the trigeminal nerve in 160 patients with chronic generalized periodontitis. Results. Revealed the presence of various degrees of violations of the functional activity of the trigeminal nerve depending on the severity of the pathological process in periodontal tissues. Conclusion.Neuroprotective therapy in the treatment of patients with periodontal disease leads to normalization of the neurophysi-ology of the trigeminal nerve and promotes more rapid relief of the infammatory process in periodontal tissues.

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Immunological disorders in formation of periodontal diseases at pregnant women

Year: 2010, volume 6 Issue: №2 Pages: 392-396
Heading: Stomatology Article type: Original article
Authors: A.V. Lepilin, M.V. Dubrovskaya
Organization: Saratov State Medical University
Summary:

The research goal is to study clinical and immunological features of parodentium and cytokine profile in oral cavity of pregnant women.
The condition of parodentium tissues was studied at 200 women with physiological pregnancy and 300 women with pregnancy complicated by gestosis. According to the results of examination 50 women with gestosis and 50 women with physiological pregnancy had inflammatory periodontal diseases. Phenotyping of lymphocytes by immunofluorescence method, investigation of necrosis containing factor of tumour-a, interleukin-8, interleukin-4 and transforming growth factor beta-1 in oral cavity by immunofermental analysis were performed.
Frequency and character of inflammatory periodontal diseases at pregnancy were defined. Correlation of gingivitis and periodontitis at pregnancy with extragenital pathology was demonstrated. Immune and cytokine disbalance contributed greatly to pathogenesis of inflammatory periodontal diseases at pregnant women.
Thus pathogenesis of oral hygiene, smoking, gestosis, immunosuppression and cytokine disbalance affects inflammatory periodontal diseases at pregnant women

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