Saratov JOURNAL of Medical and Scientific Research

Merkodanova Yu.A.

Saratov State Medical University n.a. Razumovsky, Department of Children Diseases of Therapeuticl Faculty, Post-graduate

Urinary Cytokines Spectrum of Different Etiologic and Pathogenic Types at Children with Chronic Pyelonephritis

Year: 2011, volume 7 Issue: №4 Pages: 901-904
Heading: Pediatrics Article type: Original article
Authors: Merkodanova Yu.A., Utz I.A.
Organization: Saratov State Medical University

Objective. We investigated the diagnostic role of urinary IL-1b, IL-6 and IL-8 in children with different etiologic and pathogenic variants of chronic pyelonephritis. Material and methods. 132 patients (92 girls and 40 boys) aged 1-17 with chronic pyelonephritis were examined: 18 patients with primary pyelonephritis (I group); 114 with secondary pyelonephritis (II group); 30 patients without kidney disease completed control group. Results. Our data showed increasing level of all mediators of inflammation, especially in acute stage of pyelonephritis and with 10-years anamnesis. We suggested the role of IL-6 in nephrosclerosis. Conclusion. The content of urinary IL-1b, IL-6 reflects the level of kidney inflammation, and IL-8 — the degree of inflammation. We conclude that the level of urinary IL-8 could be a new indicator for nephrosclerosis

201104_901-904.pdf366.5 KB

Mechanisms of bacteria uropathogenicity at chronic pyelonephritis in children

Year: 2010, volume 6 Issue: №2 Pages: 383-385
Heading: Pediatrics Article type: Review
Authors: Yu.A. Merkodanova
Organization: Saratov State Medical University

Рассмотрены ключевые вопросы патогенеза пиелонефрита у детей. Выделены и проанализированы основные этапы патогенеза данного заболевания: преморбидный, транслокации, колонизации, альтерации, санации и персистенции. Систематизированы ведущие механизмы и факторы уропатогенности (нефритогенности) бактериальных возбудителей пиелонефрита

201002_383_385.pdf288.37 KB