Saratov JOURNAL of Medical and Scientific Research

Grishin V.A.

Saratov State Medical University n.a. V.I. Razumovsky, Department of Psychiatry and Narcology, Assistant

Change in function of thl - and th2-lymphocytes and cytokine profile at chronic intoxication of ethanol

Year: 2010, volume 6 Issue: №2 Pages: 307-309
Heading: Anaesthesiology and Reanimatology Article type: Original article
Authors: A.A. Svistunov, P.F. Zabrodsky V.G. Lim, V.A. Grishin
Organization: Saratov State Medical University

It has been established during the experiments carried on noninbred rats that chronic intoxication of ethanol (30 days, total dose - 6,0 LD50) essentially reduces concentration of cytokines (IFNy, IL-2, IL-4, IL-6,IL-10) in blood, reduces interrelation of IFNy/IL-4 in comparison with the control, suppresses immune reactions, indicating the greater lesion of Th1-cells in comparison with Th2-lymphocytes

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