Saratov JOURNAL of Medical and Scientific Research

Prokin F.G.

Saratov State Medical University n.a. V.I.Razumovsky, Department of Hospital Surgery, Candidate of Medical Science

The role of connective tissue dysplasia in aetiopathogenesis of varicose disease and acute varicothrombophlebitis

Year: 2019, volume 15 Issue: №2 Pages: 302-307
Heading: Surgery Article type: Review
Authors: Tsarev O.A., Anisimov A.Yu., Prokin F.G., Zakharov N.N., Senin A.A., Kulikova A.N.
Organization: Saratov State Medical University
Summary:

The academic literature review presents the analysis of recent publications which focus on the role of connective tissue dysplasia in aetiopathogenesis of lower extremity varicose vein disease (LEVVD) and acute varicothrombophle-bitis (AVTPh). The ways of predicting the variants of LEVVD and AVTPh clinical course on the basis of analyzing the combination of phenotypic characteristics are examined. Key words: varicose disease, varicothrombophlebitis, connective tissue dysplasia.

Acute varicothrombophlebitis: modern approach to the problem

Year: 2018, volume 14 Issue: №1 Pages: 87-94
Heading: Surgery Article type: Review
Authors: Tsarev О.А., Anisimov A.Yu., Prokin F.G., Zakharov A.A., Lobanov A.V., Senin A.A.
Organization: Saratov State Medical University
Summary:

Acute varicothrombophlebitis, or thrombosis of superficial veins (TSV), is a dangerous complication of lower extremity varicose vein disease, as it is a frequent cause for pulmonary artery thromboembolism. The survey states the modern approach to pathogenesis, diagnostics, clinical findings and therapeutic approach to patients with TSV.

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Amputation of extremity in patients with atherosclerotic gangrene

Year: 2011, volume 7 Issue: №4 Pages: 947-953
Heading: Surgery Article type: Original article
Authors: Tsarev О.A., Prokin F.G., Zaharov N.N., Voloshuk I.N., Shinde S., Tsareva Yu.O., Imangulov A.M., Mingan T.
Organization: Saratov State Medical University
Summary:

Aim of investigation — to analyze the results of treatment of patients with atherosclerotic gangrene of a limb, to identify the causes of adverse outcomes amputation. Materials and methods: We analyzed the results of examination and treatment of 218 patients with atherosclerotic gangrene of the limb. Good outcome of amputation was considered the primary surgical wound healing of the stump. Suppuration, secondary healing, re-amputation and death we attributed to the adverse results of amputation. Results: The adverse outcomes of amputation due to technical errors in surgery, properly chosen level, inadequate drainage of the wound stump, an unsuccessful operation on the arteries of a limb, inadequate empirical antibiotic therapy, patient's age, functional capabilities of myocardium, the duration of critical ischemia, as well as the lack of psychological adaptation of patients before amputation. Conclusion: To decide the need for amputation in patients with atherosclerotic gangrene follows the assessment of possible vascular reconstructive surgery. In determining the level of amputation is necessary to objectively assess the degree of disruption of regional blood flow using multilevel manometry and laser Dopplerflowmetry. In preparation for amputation should be paid special attention to the correction of rheological and coagulation properties of blood, normalization of the functional state of the myocardium, as well as specialized psychotherapeutic training for timely and adequate psychological adaptation of the patient

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Noninvasive method of blood viscosity and hematocrit monitoring

Year: 2010, volume 6 Issue: №1 Pages: 194-198
Heading: Surgery Article type: Original article
Authors: O.A. Tsarev, F.G. Prokin, Ju.V. Mashchenko, A.I. Nabegaev, V.V. Dubanosov, A.M. Imangulov, S.A. Zyazyanov
Organization: Saratov State Medical University
Summary:

Research objective is to study substantiation of noninvasive method of blood viscosity and hematocrit monitoring. it contains the results of theoretical, experimental and clinical studies held to examine the mechanism of pulse wave distribution. The interrelation between pulse wave parameters, pulse wave velocity, systolic and diastolic blood pressure, blood viscosity and hematocrit has been revealed. Noninvasive method of blood viscosity and hematocrit determination has been worked out. it is distinguished by the following factors: pulse wave of the main artery registered at two limb levels, the amplitude of pulse wave, the duration of its trailing edge and the time of pulse wave distribution. Systolic and diastolic blood pressure are recorded. Blood viscosity and hematocrit calculations are made by means of mathematical treatment with the help of original program. the device for noninvasive blood viscosity and hematocrit monitoring has been created on the basis of elaborated method. Data precision obtained by noninvasive measurement of hematocrit and blood viscosity does not exceed 3%.
the clinical use of noninvasive method enables to approach the problem of atherosclerosis prevention, to improve the results of atherosclerosis treatment and to look at it from critically new noninvasive positions

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