Saratov JOURNAL of Medical and Scientific Research

Neurology

Innovation in diagnostics and treatment of epilepsy

Year: 2017, volume 13 Issue: №1 Pages: 143-147
Heading: Neurology Article type: Review
Authors: Kalinin V.A., Poverennova I.E., Yakunina A.V., Beketova E.M.
Organization: Samara State Medical University, Municipal Hospital No. 1 n.a. N. I. Pirogov, Samara
Summary:

The aim of the review is try to systematize the innovative achievements of modern epileptology and indicate the levels of diagnosis and treatment of epilepsy that are not sufficiently developed, from our point of view. Applied to epileptology, the innovation process is realized at all levels. In principle, you can divide the entire process into a diagnostic and treatment level. Promising in the diagnosis of epilepsy should be considered the analysis of age characteristics, new methods of EEG analysis and evoked potentials, innovative methods of functional neuroimaging, genetic testing. New anticonvulsants with the original mechanism of action allow to overcome pharmaco-resistance of epilepsy in a number of observations. In rare cases it is necessary to use minimally invasive surgical methods of treatment.

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Neurological presentations of a secondary antiphospholipid syndrome

Year: 2017, volume 13 Issue: №1 Pages: 139-143
Heading: Neurology Article type: Case report
Authors: Yesaulenko I.E., Kutashov V.A., Ulyanova O.V.
Organization: Voronezh State Medical University n.a. N.N. Burdenko
Summary:

The aim of the study is to turn the attention of specialists to antiphospholipid syndrome (APS), which is of interest to physicians of many specialties. The observation of the patient W., 32 years, with secondary APS was analyzed. Poor prognostic factors in CFA are the high frequency of thrombotic complications and thrombocytopenia, and laboratory markers — the presence of lupus anticoagulant. All patients with APS should be under medical supervision, whose main task is to assess the risk of recurrence of venous or arterial thrombosis and its prevention.

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Epidemiology analysis of Parkinson's disease in Rostov-on-Don

Year: 2017, volume 13 Issue: №1 Pages: 135-139
Heading: Neurology Article type: Original article
Authors: Goncharova Z.A., Rabadanova Е.А., Gelpey M.A.
Organization:
Summary:

In orderto improve the assistance provided to patients with Parkinson's disease (PD) it is necessary to conduct epi-demiological analysis, the establishment of the register, the clinical analysis. In Rostov-on-Don (population: 1114806 on 01.12.2015) epidemiological analysis of PD is carrying out for the first time. The aim of this study was to analyze the main epidemiological indicators of PD in the population of Rostov-on-Don to support, organize and optimize the system of treatment and preventive care for these patients. Material and methods. The object of study was 661 patients (415 women and 246 men). Results. Epidemiological analysis of PD in Rostov-on-Don has shown that the prevalence and incidence of line with the average for the country. We have revealed the hypodiagnostics at the first stage of the disease. We have also identified gender features: the predominance of women, which is contrary to the results of most studies that have demonstrated the predominance of men. We have found that in 16.9% PD first symptoms were observed in aged under 60 years, i.e. in people of working age. Conclusion. Establishment of a register and the city center of diagnostics and treatment of extrapyramidal disorders has improved diagnosis and quality of follow-up for these patients. It is needed to improve the quality of diagnosis by general practitioner.

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The turmeric protective properties at ethanol-induced behavioral disorders.

Summary:

The aim of the study was to determine the effect of mechanically modified turmeric extract on the parameters of orienting-exploratory behavior in mice with chronic ethanol consumption. Material and methods. Mice behavior was assessed in the "open field" test. In the both control groups the animals received water or 10% ethanol solution; in the test group — turmeric extract in 10% ethanol solution. Amount of blood mononuclear cells, thymocytes, and splenocytes were estimated. Results. Analysis of the behavioral parameters in animals after chronic exposure to ethanol showed suppression of motor and exploratory components of the behavior. In mice that received both ethanol and turmeric extract recorded behavior parameters were significantly higher than in the group of animals who received ethanol only. It was shown that the turmeric extract enhances the amount of blood immune cells. Conclusion. Mechanically modified turmeric extract possesses protective properties against ethanol-induced behavioral disorders.

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Social and psychological components in rehabilitation medicine

Year: 2017, volume 13 Issue: №1 Pages: 127-131
Heading: Neurology Article type: Original article
Authors: Akhmadeeva L.R., Khokh I.R., Khusnitdinova S.R., Timirova A.F., Akhmadullin F.F., Akhmadeeva E.N.
Organization: Interdisciplinary Institute, Bashkir State Medical University of the Russian Health Care
Summary:

Aim: analysis of the current status and evaluation of the effectiveness of rehabilitation measures for patients with impaired motor function in the early recovery period of cerebral stroke in the conditions of a specialized inpatient department. Material and methods. The data of the state of patients with motor deficit after a cerebral stroke were analyzed in the rehabilitation department from November 2016 to March 2017. Results. During the study period, the effectiveness of the rehabilitation department for patients in the early recovery period of cerebral stroke was assessed. Improvements in cognitive functions were detected in these patients, and these patients also have a high potential for self-esteem of the social significance of the disease and the condition (anxiety and depression) at the time of being in the inpatient rehabilitation department. Conclusion. The presented data testify to the need to take into account the characteristics of patients in the early recovery period of cerebral stroke in the development of rehabilitation activities within the inpatient department.

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Konstantin Nikolaevitch Tretiakoff: some of the biography pages (the 125th anniversary of the birth)

Year: 2017, volume 13 Issue: №1 Pages: 123-127
Heading: Neurology Article type: Short message
Authors: Kolokolov O.V., Razdorskaya V.V., Yudina G.K.
Organization: Saratov State Medical University
Summary:

Konstantin Tretiakov is one of the founders of Neurological science schools in Sao Paulo (Brazil) and in Saratov. Carrying out the analysis of the materials of the State archive of Saratov, the Russian State Library, the Russian National Library, the library of Saratov Medical University, Internet resources. The information about the K.N. Tretiakov's life, career and scientific work Tretiakov is presented.

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Effectiveness criteria of early rehabilitative treatment of patients with postoperative upper plexopathy

Year: 2017, volume 13 Issue: №1 Pages: 057-061
Heading: Neurology Article type: Original article
Authors: Tosheva M.l., Sholomov I.I., Sholomova E.l.
Organization: Saratov State Medical University
Summary:

The damage of the peripheral nervous system often acts as a complication of extensive surgical interventions on the removal of malignant breast tumors. The research goal is to evaluate the criteria for the effectiveness of early rehabilitation treatment of postoperative upper plexopathies. Material and Methods. The analyzed results of complex diagnosis and treatment of 162 women undergoing radical mastectomy for breast cancer, aged 33 to 79 years were presented. The examination included neurological examination, analysis of the psychological state using the HADS scales, Janet Taylor and HDRS, holding electroneuromyography Results. 98.76% of cases of patients after radical mastectomy for malignant breast tumors were diagnosed with unilateral shoulder complex. At 1.24% it established a bilateral lesion of the brachial plexus. The presence of pain is not a leading complaint in all cases. Among patients with classical mastectomy performed significantly prevailed damage of the intercostal nerves III and IV. In post-operative patients with the retrofit radical mastectomy neuro- and plexopathy were often diagnosed. Consent to one-stage reconstructive surgery is directly correlated with the level of education and marital status. Indicators of depression and anxiety were lower after reconstructive plastic surgery. Conclusion. The criteria for the effectiveness of early rehabilitation treatment of postoperative upper plexopathies were obtained. The decisions on the nature and scope of reconstructive and plastic surgery were established to be in conjunction with the social components of life of patients.

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Quality of life, anxiety-depressive disorders and cognitive functions on the background of rehabilitative period of ischemic stroke

Year: 2017, volume 13 Issue: №1 Pages: 051-057
Heading: Neurology Article type: Original article
Authors: Belskaya G.N, Lukyanchikova L.V.
Organization: Chelyabinsk Regional Clinical Hospital №3 , South Ural State University (National Research Institute)
Summary:

The aim of the work is to evaluate the quality of life, cognitive deficits, the development of anxiety and depression of patients in rehabilitative period of mild and medium-severe hemispheric ischemic stroke during the year at the background of complex rehabilitation. Materials and Methods. We examined 123 patients at the age of 40 to 80 with ischemic stroke in the acute and rehabilitation periods (up to 1 year). Quality of life (overall life questionnaire SF-36, overall performance), the state of cognitive functions (the MMSE scale), the level of anxiety and depression (the HADS and the MADRS scale) during the acute phase and after a course of rehabilitation treatment have been assessed. Re-sults. After rehabilitation in the sanatorium positive dynamics of physical and psychological well-being was noted with patients, cognitive function was improved as well as emotional regression of personality disorders in the first 3 months after ischemic stroke. These effects are related with individual program of rehabilitation on an outpatient phase, including cognitive and neuropsychological correction leading to a clear positive dynamics of the main indicators of cognitive status, reduction of anxiety and depressive disorders, improving physical and mental health components of the SF-36 questionnaire in the course of the year. Conclusion. The findings proved that during the complex rehabilitation after an ischemic stroke during a year the marked high levels of "quality of life" including reducing anxiety and depression and regression of cognitive impairment were revealed.

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Pain syndrome features in Parkinson's disease

Year: 2016, volume 12 Issue: №4 Pages: 706-712
Heading: Neurology Article type: Review
Authors: Bril Е.М., Udalov U.D., Anikina M.A., Zimnyakova O.S.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency
Summary:

Pain in Parkinson disease take the special place among all of disease symptoms due to it pathogenetics and clinical diversity. In spite of the plurality of resent studies, the majority of clinical practioners and neurologists didn't pay attention to significant decline of the quality of life in patients with Parkinson disease and pain disorders. This article was created with aim to summarize all important results of studies, focused on pain pathogenesis and clinical features on different stages of disease.

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Comorbid diseases at patients with HIV-induced neurological disorders

Year: 2016, volume 12 Issue: №3 Pages: 388-390
Heading: Neurology Article type: Original article
Authors: Sholomova E.l., Rebrov К.А., Sholomov I.I.
Organization: Saratov City clinic №11, Saratov State Medical University
Summary:

Objective: to estimate the structure and frequency of detection of secondary diseases in patients with neurological manifestations of HIV infection. Materials and methods. The study involved 304 patients infected with HIV. Results. The defeat of the nervous system in HIV infection occur encephalopathy, cerebral vascular lesions, meningitis, subacute encephalitis, secondary CNS lesions. The number of CD4-lymphocytes in HIV-infected patients with neurological disorders was significantly lower. Most of them have comorbid diseases. The most commonly diagnosed hepatitis С and B, herpes, cytomegalovirus infection, chlamydia, Candida, toxoplasmosis and tuberculosis, mixed infection. Hepatitis В and С and herpes are the most widely represented in patients with HIV-induced encephalopathy and cerebrovascular form of HIV. The presence of cytomegalovirus infection is correlated with the development of subacute encephalitis. Conclusion. Manifestations of nervous system pathology in HIV polymorphic and correlated with the presence of secondary comorbid pathology. Such conditions are due to underlying disease immunological parameters.