Saratov JOURNAL of Medical and Scientific Research

Shapovalova T.G.

Saratov State Medical University n.a. V.I. Razumovsky, Department of Therapy of Pediatric Faculty and Stomatological Faculty, Professor, Doctor of Medical Science

Professor M.M. Kirillov (to the birth anniversary)

Year: 2018, volume 14 Issue: №1 Pages: 107-108
Heading: anniversary Article type: Short message
Authors: Shapovalova T.G., Ryabova A.Yu., Shashina M.M.
Organization: Saratov State Medical University
Summary:

The article is devoted to the 85th anniversary of the honored doctor of the Russian Federation, Professor M.M. Kirillov.

AttachmentSize
2018_1_107-108.pdf1.49 MB

Prediction of heart remodeling in patients with bronchial asthma

Year: 2018, volume 14 Issue: №1 Pages: 49-52
Heading: Internal Diseases Article type: Original article
Authors: Ryabova A.Yu., Shapovalova T.G., Shashina M.M., Lekareva L.I., Kudishina M.M.
Organization: Saratov State Medical University
Summary:

The aim of the study was to identify cardiac remodeling in bronchial asthma (BA), to construct a mathematical model for its prediction to optimize diagnosis. Material and Methods. Atotal of 283 patients with asthma who underwent a comprehensive examination including general clinical, immuno-enzymatic (determination of the N-terminal fraction of the brain natriuretic propeptide, activity of the angiotensin-converting enzyme) and instrumental methods: ECG, ECHO, daily Holter monitoring of ECG, FVD. Results. The analysis of the obtained results showed that in patients with asthma, structural, geometric changes of the myocardium of the right and left ventricles were noted, increasing as the disease became more severe. The activation of local neurohormonal systems, primarily myocardial is no less important. An analysis of the relationship between the concentration of natriuretic peptide and the end-diastolic size of the right ventricle in BA patients revealed a moderate correlation relationship. There was a weak correlation between the right ventricular end-diastolic size, the right ventricular frontal wall thickness and the ACE level. The analysis of the relationship between the above dimensions of the right ventricle and the index of the balance of the autonomic nervous system was reliable. Conclusion. Thus, the development of cardiac remodeling in AD patients occurs against the background of the hyperactivation of neurohumoral systems, including sympathoadrenal, renin-angiotensin-aldosterone and the system of natriuretic peptides.

AttachmentSize
2018_1_049-052.pdf260.04 KB

Pulmonary lymphangioleiomyomatosis (case report)

Year: 2017, volume 13 Issue: №4 Pages: 828-833
Heading: Internal Diseases Article type: Case report
Authors: Shashina M.M., Shapovalova T.G., Kazimirova N.E., Ryabova A.Y., Arkhangelskaya Е.Е., Lifanova D.V., Chernyshkova M.A.
Organization: Saratov State Medical University, Saratov Clinical Hospital № 8
Summary:

This article presents a clinical observation of a patient with a proven diffuse-nodular form of lymphangioleiomyomatosis of the lungs. Features of the course of the process against the background of pathogenetic therapy which included sirolimus and progesterone have been considered. It is necessary to raise awareness of doctors about the disease that facilitates timely diagnosis and treatment.

AttachmentSize
2017_04_828-833.pdf2.43 MB

Hemodynamics features and contractive miocardial function in patients with chronical obstructive pulmоnаry diseases accompanied by bronchial asthma

Year: 2010, volume 6 Issue: №1 Pages: 084-088
Heading: Internal Diseases Article type: Original article
Authors: T.G. Shapovalova, M.V. Volkova, N.V. Shelobanova, A.Yu. Ryabova, L.I. Lekareva
Organization: Saratov State Medical University
Summary:

Hemodynamics and contractive myocardial function features in patients with chronic obstructive pulmonary disease (OOPD) accompanied by bronchial asthma have been examined. The changes of cardiohemodynamics have been presented according to the ventilation disorders level, balance of blood cytokines (IL-4, IL-6, IL-8, TFN-a) and adhesion molecules level (IOAM-1, VOAM-1)

AttachmentSize
201001_084_088.pdf326.5 KB

Features of The Heart Remodeling in Patients with Chronic Obstructive Pulmonary Diseases, Combined with Coronary Heart Diseases

Year: 2009, volume 5 Issue: №3 Pages: 352-355
Heading: Internal Diseases Article type: Original article
Authors: T.G. Shapovalova, N.V.Shelobanova, M.V. Volkova, A.Yu. Ryabova, L.I. Lekareva
Organization: Saratov State Medical University
Summary:

The characteristics of heart remodeling in patients with chronic obstructive pulmonary diseases ( COPD), associated with coronary heart diseases (CHD) were examined. The changes of structural and functional state of myocardium, intracardiac relationships with associated pathology were under study. The role of blood inflammatory cytokines (IL-6, IL-8, TNF-a) and the level of cell adhesion molecules (ICAM-1, VCAM-1) in exacerbating myocardial dysfunction was clarified.

AttachmentSize
200903_352_355.pdf265.07 KB

Medication and Plasmapheresis Efficacy in Bronchial Asthma Combined with Arterial Hypertension

Year: 2009, volume 5 Issue: №2 Pages: 194-197
Heading: Internal Diseases Article type: Original article
Authors: T.G. Shapovalova, T.V. Stepanova, S.B. Smolyak
Organization: Saratov Clinical Hospital N 8, Saratov State Medical University
Summary:

Expiration function, cardiohemodynamics and blood viscosity indices have been investigated in 178 patients in order to evaluate the efficacy of plasmapheresis application in complex therapy of acute bronchial asthma combined with arterial hypertension. Complex therapy proved to be advantageous.

AttachmentSize
200902_194_197.pdf285.91 KB

RISK FACTORS, REHABILITATION AND CLINICAL EXAMINATION PRINCIPALS OF COMMUNITY ACQUIRED PNEUMONIA IN MILITARY SERVICEMEN

Year: 2009, volume 5 Issue: №1 Pages: 70-72
Heading: Internal Diseases Article type: Original article
Authors: N.M. Redjko, T.G. Shapovalova, V.A. Savinov
Organization: Saratov Military Medical Institute, Saratov State Medical University
Summary:

Clinico-epidemiological analysis has been performed to reveal exogenic and endogenic riskfactors of community acquired pneumonia military servicemen at conscription. Riskfactors of CAP at conscription include smoking, overcooling, chronic infection foci, preceding ARVI, and the first-half-year of service. The residual effects after CAP in military servicemen predominantly are the obstructive disorders of outer respiratory function as well as radiological symptoms as deformity of pulmonary picture and pleural overlay. The educational scheme has been developed for CAP patients. No recurrent infections of the upper and lower respiratory passageways have occurred during the following years of military service in patients under the follow-up care.

AttachmentSize
200901_070_072.pdf162.04 KB