Saratov JOURNAL of Medical and Scientific Research

Ruta A.V.

Saratov State Medical University n.a. V.I. Rasumovsky, Department of Pharmacology and Clinical Pharmacology, Assistant, Candidate of Medical Science

Genetic pathogenesis of essential arterial hypertension (the review)

Year: 2011, volume 7 Issue: №1 Pages: 083-087
Heading: Internal Diseases Article type: Review
Authors: Shevchenko O.V., Svistunov А.А., Borodulin V.B., Ruta A.V., Bychkov E.N.
Organization: Saratov State Medical University, First Moscow State Medical University n.a. I.M. Sechenov

It is proved that genetic factors may be considered as fundamental in the development of essential arterial hypertension (AH). Important role in this process belongs to the genes whose products are involved in regulating blood pressure - adrenergic, renin-angiotensin-aldosterone, and homocyclic bradykinin systems. These systems are closely connected by serial and parallel chemical reactions that enable to use genetic testing to determine the state of the whole system. Analysis of polymorphic markers of different groups of genes encoding components of the renin-angiotensin-aldosterone system allows to define the role of each of the pathogenic factor of hypertension in the development of the disease

201101_083-087.pdf258.4 KB

Peculiarities of bone metabolism in patients with multiple myeloma

Year: 2010, volume 6 Issue: №1 Pages: 048-052
Heading: Physiology and Pathophysiology Article type: Original article
Authors: A.A. Svistunov, A.V. Ruta, O.V. Shevchenko
Organization: Saratov State Medical University

Multiple myeloma is one of the most widespread hemoblastosis. In the structure of oncohematology it takes up about 10%. It follows with destruction of bones and results in lethal outcome. Ostealgia’s syndrome is leading in more than 70% of patients at the beginning of this medical condition. Damage of the skeleton is found at 80% of patients by means of X-ray. Patients suffer from decrease of osseous tissue mineral density and increase in level markers of osseous resorption and elaboration (bones acid and alcaline phosphatases, desoxypiridoline). These indices can be used as predictors of efficiency and safety of treatment of osteopenia in patients with multiple myeloma

201001_048_052.pdf314.74 KB