Saratov JOURNAL of Medical and Scientific Research


Effects of the vaccine "Grippol" on resistance of mice after irradiation by protons

Year: 2015, volume 11 Issue: №4 Pages: 656-658
Heading: radiation medicine Article type: Short message
Authors: Ivanov А.А., Abrosimova A.N., Bulinina Т.М.
Organization: State Scientific Research Center n.a. A.I. Burnasyan — Federal Medical Biophysical Center of Federal Medical Biological Agency

Aim: to investigate the effect of the vaccine "Grippol" on radioresistance with respect to proton irradiation. Material and methods. The effect of the vaccine "Grippol" the survival of the animals was studied in mice CBAxC57BI F1, which was immunized for 10 days prior to proton irradiation. Results. It is shown that proton irradiation causes the death of the animals at all doses tested: 9% at a dose of 7.0 Gy; 10% — 8.0 Gy and 33% after irradiation at a dose of 8.5 Gy, at the same time the survival rate after pre vaccination study groups was 100%. It seems appropriate to further study the impact of the vaccine "Grippol" at low doses of proton irradiation using appropriate test evaluation of hematological, im-munological, genetic, physiological and other factors. Conclusion. The vaccine "Grippol" introduction into mice before lethal proton irradiation increases survival of protected animals.

Assessment of alveolar-capillary disturbances in development of severe hemodynamic pulmonary edema in rats and their correction with SHF radiation

Year: 2011, volume 7 Issue: №2 Pages: 389-392
Heading: Physiology and Pathophysiology Article type: Original article
Authors: Terekhov I.V., Dzyuba M.A., Bonder S.S., Nadzharian L.G.
Organization: Saratov Military Medical Institute

The article presents the study on the effect of SHF radiation of 0.01-0.2-mcW/cml intensity on alveolar-capillary permeability state and rat survival with hemodynamic adrenaline pulmonary edema in vitro. Animals of different sex showed dissimilar sensitivity to edema adrenaline action and to super high frequency of SHF radiation. SHF radiation of 0,05 MW/cml is optimal from the viewpoint of its effect for the period of survival of both male and female rats, accompanied by prolongation of their life span to 59.2% and 95.5% respectively. The hypothesis of modulating action of low intensity SHF radiation on endothelial functional state has been considered. It results in rehabilitation of cardiovascular system reactivity and significant prolongation of life span.

201102_389-392.pdf268.97 KB

Results Of Orthotopic Bladder Creation After Radical Cystectomy In Patients With Bladder Cancer

Year: 2009, volume 5 Issue: №4 Pages: 615-619
Heading: Urology Article type: Original article
Authors: V.A. Atduev, A.B. Stroganov, Yu.O. Lyubarskaya, D.S. Ledyaev, V.V. Schutov, G.A. Berezkina, H.M. Mamedov, A.A. Bazaev
Organization: Nizhni Novgorod Regional Clinical Hospital named after N.A.Semashko, N. Novgorod State Medical Academy

This article presents the results of 116 radical cystectomies of patients with bladder cancer. In all the cases various generated modifications of orthotopic bladder including the authors' methodology have been carried out. The structure of complications during the post-operative period has been analyzed. Various complications occurred in 16,4 % of patients. In 3,4 % of cases they caused death. In 74% of cases direct dependence of postoperative complications on advanced tumorous process and severity of accomponied pathology has been identified. Direct dependence on the selection of method of urine derivation has not been found. Five-year cancer survival rate accounted 70 %. The study of patients' quality of life has been performed using EORTC-QLQ-C-30. High indices have been worked out. Dependence on the method of orthotopic bladder creation has been negligible

200904_615_619.pdf2.09 MB