Saratov JOURNAL of Medical and Scientific Research

multiple sclerosis

Diagnostic criteria for optic nerve atrophy in patients with multiple sclerosis determined by next generation spectral optical coherence tomography

Summary:

Purpose: identifcation of diagnostic criteria for optic nerve atrophy by spectral optical coherent tomography in patients with multiple sclerosis (MS). Material and Methods. 81 patients with optic nerve atrophy due to MS (37 men, 44 women, mean age 35.6±3.7 years) were examined using spectral optical coherent tomography (S-OCT). Results. We obtained reliable data suggesting on the asymmetry of S-OCT parameters in patients with multiple sclerosis and optic nerve atrophy. In the process of a detailed assessment of the thickness of the GCS+IPL complex, signifcant difer-ences in the worst and paired eyes were obtained. In addition, when the total aggregating all of the results obtained by the method of binary logical regression determined the threshold for partial atrophy of the optic nerve due to MS. The average thickness of GCS+IPL complex, as determined by S-OCT, is a reliable marker of neuroaxonal degeneration in patients with optic nerve atrophy due to MS. Conclusion. S-OCT criteria for optic nerve atrophy in multiple sclerosis are a decrease in the average thickness of the retinal nerve fber layer of less than 62 microns, combined with a decrease in the average thickness of retinal ganglion cell complex and the inner plexiform layer less than 52 microns, thickness of upper segment of GCS+IPL less than 51 μm, and the lower segment of GCS+IPL less than 50 microns.

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Results of a seven-year follow-up of an atypical form of multiple sclerosis, Marburg variant

Year: 2019, volume 15 Issue: №2 Pages: 414-418
Heading: Ophtalmology Article type: Case report
Authors: Andrusyakova Ye.P., Ioyleva Ye.E., Safonenko A.Yu., Krivosheeva M.S., Pis'menskaya V.A.
Organization: "Eye Microsurgery" n.a. academician S. N. Fedorov, Volgograd branch, Moscow State Medical Stomatological University n.a. A. I. Evdokimov
Summary:

Marburg disease afects young people and is characterized by an acute onset with a fulminant course. The disease leads to death within 1 year from the onset of symptoms. In Academician S. N. Fedorov «Eye Microsurgery» Center (Moscow) a patient with Marburg multiple sclerosis was followed up for seven years. Standard treatment in combination with physiotherapy treatment slowed the development of an irreversible decrease in visual function due to atrophy of the optic nerves.

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Multimodal evoked potential in monitoring activity relapsing and remitting multiple sclerosis

Year: 2018, volume 14 Issue: №1 Pages: 157-160
Heading: Neurology Article type: Original article
Authors: Poverennova I.E., Zakharov A.V., Khivintseva E.V.
Organization: Samara State Medical University
Summary:

The aim of the study was to examine multimodal evoked potential in patients with or without relapse
multiple sclerosis during 12 month. Material and Methods. The study included 32 patients with
established diagnosis of clinically significant multiple sclerosis, a relapsing-remitting course. The EDSS
score was evaluated. All patients underwent a study of multimodal evoked potential. All examined
patients were divided into 2 groups depending on the relapse multiple sclerosis by the end of the year.
Results. Multimodal evoked potentials show ambiguous data on the activity of multiple sclerosis. The
greatest correlation with subsequent activity of multiple sclerosis is shown by stem evoked potentials.
Conclusion. This study is the initial stage in the search for a tool for predicting the course of the disease
in patients with multiple sclerosis. An increase in the group of subjects and inclusion in the analysis of
structural changes in the central nervous system according to magnetic resonance imaging probably will
increase the information content of predictions.

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"Benign" multiple sclerosis: a variant of favorable disease course and the result of effective treatment

Year: 2018, volume 14 Issue: №1 Pages: 153-156
Heading: Neurology Article type: Review
Authors: Makarov N.S., Kolokolov O.V.
Organization: Saratov State Medical University
Summary:

The article provides an overview of data on isolated demyelination syndromes that may precede multiple sclerosis, and on the peculiarities of the so-called "benign" form of multiple sclerosis. Clinical and anamnestic criteria for establishing the fact of a "benign" form of multiple sclerosis are presented, as well as trends in the number of these patients in the general population of patients with multiple sclerosis, including in connection with the improvement of treatment methods for this disease.

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Features of psychoemotional disorders in patients with multiple sclerosis in different clinical and demographic groups

Year: 2018, volume 14 Issue: №1 Pages: 151-153
Heading: Neurology Article type: Short message
Authors: Lukina E.V., Chernysheva О.А., Eliseeva V.A.
Organization: Saratov State Medical University
Summary:

Purpose: to conduct an analysis of psychoemotional disorders in patients with multiple sclerosis, who are not receiving any treatment for these disorders. Material and Methods. A cohort of patients with a reliable diagnosis of multiple sclerosis, according to the criteria of С Poseur, consisting of 163 people, was selected for the research. A four-dimensional symptomatic questionnaire was used to assess distress, depression, anxiety and somatization (4DSQ) and a self-questionnaire for evaluating the symptoms of fibromyalgia with quantitative measures (WPI, SS, FS). Re-sults. Differences in the average values of the level of distress, depression, anxiety and somatization in patients with multiple sclerosis of different sex, age, with different type of course and duration of the disease are shown. Conclusion. The neuropsychological status of patients depends on the type of course of the disease, the level of distress — from age and sex, the level of somatization —from the age of this category of patients. In the complex treatment of this category of patients it is necessary to use symptomatic treatment in addition to pathogenetic therapy, which has not only neurotrophic and vasoactive effects, but also affects the psychoemotional background of patients.

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Clinical and immunological features of multiple sclerosis combined with persistent herpes viral infection

Year: 2018, volume 14 Issue: №1 Pages: 126-132
Heading: Neurology Article type: Original article
Authors: Goncharova Z.A., Belovolova R.A., Megerian V.A.
Organization: City Hospital №1 n.a. N.A. Semashko
Summary:

The purpose of the study is to evaluate the symptomatology of multiple sclerosis (MS) and to evaluate the immune status in patients with reactivation of persistent herpes viral infection (PHVI). Material and Methods. We examined 56 patients with definite multiple sclerosis (MS) and 20 patients treated for other diseases of nervous system (radicu-iar syndrome caused by degenerative disease backbone) (comparison group). The MS patients were divided into 2 groups: patients without reactivation of PHVI (typical MS) and patients with reactivation of PHVI (virus-associated MS). The PHVI reactivation was registered in the case of presence of the appropriate clinical features and it was also verified by serological methods (ELISA). The symptomatology of MS was evaluated according to FS and EDSS scales. We performed the study of cell and humoral adaptive immunity. Results. Patients with reactivation of PHVI had more significant neurological symptomatology, more frequent relapses of MS, a higher speed of MS progression compared with typical MS patients. The immune status features in virus-associated MS patients can be estimated as a combination of secondary immunodeficiency (T-cell mediated) and active autoimmune process (the activation of B-cell component). Conclusion. It was revealed more significant neurological symptomatology, severer MS course and markers of secondary immunodeficiency in MS patients with reactivation of PHVI.

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Early detection of cognitive impairment in patients with multiple sclerosis

Year: 2017, volume 13 Issue: №1 Pages: 164-168
Heading: Neurology Article type: Original article
Authors: Poverennova I.E., Romanova T.V., Zakharov A.V., Khivintseva E.V.
Organization: Samara State Medical University
Summary:

The aim of the study was to examine cognitive impairment in patients with multiple sclerosis with an emphasis on the speed and efficiency of information processing. It was supposed to reveal the patterns of these disorders depending on the duration and severity of the disease. Material and methods. The study included 50 patients with established diagnosis of clinically significant multiple sclerosis, a relapsing-remitting course. The EDSS score was evaluated. Cognitive functions were assessed using SDMT and PASAT-3 tests. All patients underwent a study of cognitive evoked potential. All examined patients were divided into 2 groups depending on the duration of the disease. Results. Cognitive screening tests PASSAT and SDMT showed no correlation with the duration of the disease severity and cannot serve as a tool for screening early signs of cognitive impairment in young patients with multiple sclerosis. A significant increase in latency of the P300 potential was obtained with increasing duration and severity of the disease, which correlates with the severity of cognitive dysfunction. Conclusion. This study is the initial step in the search for a tool for screening early manifestations of cognitive impairment in patients with multiple sclerosis. In the future it is planned to expand the research with the modernization of its design.

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Differential diagnosis of optic-spinal multiple sclerosis variant and Devic's disease among Mongoloid race representatives

Year: 2017, volume 13 Issue: №1 Pages: 155-157
Heading: Neurology Article type: Case report
Authors: Makarov N.S.
Organization: Saratov State Medical University
Summary:

The article provides an overview of the information on the racial peculiarities of some demyelinating diseases of the representatives of Asian nationalities and related methodological difficulties of differential diagnosis. Pay attention to a clinical example of a diagnostic situation.

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Cognitive impairment in multiple sclerosis

Year: 2016, volume 12 Issue: №2 Pages: 267-270
Heading: Neurology Article type: Original article
Authors: Kutashov V.A., Ulyanova O.V., Khabarova T.Y., Budnevsky A.V.
Organization: Voronezh State Medical University n.a. N.N. Burdenko
Summary:

Aim: to identify the degree of cognitive impairment (CN) and to optimize the treatment of patients with multiple sclerosis (MS). Material and methods. A total of 695 patients (278 men and 417 women) were ranged from 18 to 63 years. The mean age was 30.2±0.7 years: women (417) 28.5±0.5 years, while for men (278) 31.8±0.7 years. Relaps-ing-remitting type (RT) of MS was established in 520 patients (74.8%), secondary progressive type (VPT MS) in 132 patients (18.9%) and primary progressive type (PPT MS) in 10 patients (1.5%). Clinically isolated syndrome (CIS) was detected in 33 patients (4.8%). The diagnosis of MS 662 patients according to the criteria McDonald etal. (2005). Score of neurologic deficit was carried out on an extended scale of disability (Expanded Disability Status Scale — EDSS). CN were evaluated by conventional tests. To estimate the orientation in time, assessment of short-term and long-term memory, attention and concentration, as well as executive functions, memory, language, evaluation of optical-spatial activities, conceptual thinking, the account used by the Montreal Cognitive Assessment Scale (MoCA). For the screening of dementia with a primary lesion of the frontal lobes and subcortical cerebral structures used battery frontal test to assess frontal dysfunction. Results. The ratio of male (265) and female (397) was 1:1.5. The severity of the condition patients EDSS scale ranged from 1.5 to 8.0 points, and the average score was 3.5±1.2. In the group of patients with RT RS average score EDSS was more than a half (2.5±1.1), than in the group of patients with MS VAC (5.5±1.2) and POS PC (6.5±1.2). In the study of history, it was found that the development of the RS (662 patients) was preceded by the following conditions: a viral infection in 277 patients (41.84%); fatigue in 147 patients (22.21%); transferred psycho-emotional load from 218 (32.93%); after pregnancy and childbirth in 20 patients (3.02%). Conclusion. Among the patients with MS often met type remitting course of the disease. CN were diagnosed in 82.93% of patients. Some patients KN come to the fore in the onset of the disease, with minimal neurologic deficit, which significantly complicates the treatment and impairs the subsequent social adaptation of this group of patients. In the patients with a VPT MS KH level was statistically significantly lower than in patients with RT RS.

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Seasonal pattern to multiple sclerosis in newborns in Bashkortostan

Year: 2013, volume 9 Issue: №4 Pages: 697-699
Heading: Neurology Article type:
Authors: Magzhanov R.V., Sharafutdinova L.R., Bakhtiyarova K.Z.
Organization: Bashkiria State Medical University
Summary:

Research objective is to investigate the seasonal pattern to multiple sclerosis (MS) in newborns in the Republic of Bashkortostan (RB) depending on months of year in comparison with the RB population. Materials. Months of the birth of 1224 patients with MS republican have been analyzed in the center of the Republic of Bashkortostan (Ufa). The data of patients were compared to the data of birth rate in the RB within a year. Results. The majority of patients was born in May (12%), and the minimal amount of patients was determined in November (5.6%) and December (4.4%) that authentically differs from the rate of birth in various months of the year in the RB (p

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