Saratov JOURNAL of Medical and Scientific Research

psoriatic arthritis

Regional peculiarities of the morbidity of psoriasis and psoriatic arthritis

Year: 2018, volume 14 Issue: №4 Pages: 724-727
Heading: Dermatovenerology Article type: Original article
Authors: Nelyubova O.I., Sazanova G.Yu., Razdevilova O.P.
Organization: Saratov State Medical University
Summary:

Objective: to analyze the incidence of various forms of psoriasis in the population of the Saratov region for the period from 2009 to 2016 Material and Methods. We studied the indicators of the total and primary incidence of psoriasis in the adult population in the Saratov region for the period from 2009 to 2016 in comparison with similar indicators for the Russian Federation (RF), according to the Ministry of Health of the RF Results. It is revealed that for the period 2009-2016 the overall incidence of adult psoriasis in the Saratov region increased by 5.8%, in the RF by 13.8%; the overall incidence of adult psoriatic arthritis in the Saratov region increased by 8.1 %, in the RF by 2.2%; Primary morbidity of the adult population of psoriatic arthritis in the Saratov region increased by 11.4%, in the RF by 2.3%. Primary incidence of psoriasis for the period 2009-2016 among the adult population in the Saratov region decreased by 18.5%, in the RF by 45%, which also reflects the dynamics in the RF. Conclusion. The steady increase in the overall incidence of psoriasis and psoriatic arthritis in the adult population, the level of primary morbidity in psoriatic arthritis directly affects the costs and level of the state budget and requires ways to find ways to improve the organization of medical care of a dermatovenerological profile.

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Analysis of a real practice in hospital pharmacotherapy psoriatic arthritis

Year: 2016, volume 12 Issue: №3 Pages: 498-500
Heading: Dermatovenerology Article type:
Authors: Levitan A.l., Reshet'ko O.V.
Organization: Saratov State Medical University
Summary:

The Aim of the study: to define the characteristics of the current treatment of psoriatic arthritis in the settings of specialized medical care in a hospital, based on pharmacoepidemiological study, to optimize the treatment of such patients. Material and Methods. A retrospective pharmacoepidemiological study is based on an analysis of medical records of hospitalized patients rheumatology department requesting assistance in the period from January 2016 to April 2016. Result. As a part of basic anti-inflammatory therapy of psoriatic arthritis, methotrexate was used in 67% patients, sulfasalazine in 25% patients, and cyclosporine and D-penicillamine in 4% patients. Genetically engineered biologic drugs (GEBD) were not used. The anti-inflammatory therapy in hospital was carried out with glucocorticosteroids in 33% patients, with non-steroidal anti-inflammatory drugs (NSAIDs) in 20% cases and in 47% cases a combination of both was used. Gastroprotective therapy was given to all patients receiving corticosteroids and NSAIDs. Conclusion. The study shows that, the treatment of psoriatic arthritis meets the current recommendations, although there are problems associated with excessive use of corticosteroids and the lack of GEBD.

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Nosometamorphosis of psoriasis in the Saratov region

Year: 2016, volume 12 Issue: №3 Pages: 467-475
Heading: Dermatovenerology Article type: Original article
Authors: Nelyubova O.I., Utz S.R.
Organization: Saratov State Medical University
Summary:

Aim: to study the clinical polymorphism of psoriasis widely in Saratov region for the last 30 years period. Materials and methods. A retrospective analysis of medical records of 2083 patients with various forms of psoriasis, which were hospitalized at the Clinic of Skin and Venereal Diseases of Saratov Medical Institute in the period from 1984 to 1988 and data for statistical comparison from register of 1450 medical records of patients with various forms of psoriasis, also hospitalized at the Clinic of Skin and Venereal Diseases of Saratov State Medical University in the period of 2009-2013. Results. An increase in the incidence of severe and atypical forms of dermatosis is noted. Exudative and pustular forms of psoriasis are found more commonly. Psoriatic arthritis is noted to be slightly more associated with exudative form. Conclusion. The risk of psoriasis developing is noted in the age group of 10-30 years. In psoriatic arthritis an increase in morbidity is noted in the period of 30-60 years.

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Nervous system diseases comorbid to psoriasis

Year: 2016, volume 12 Issue: №2 Pages: 300-303
Heading: Neurology Article type: Review
Authors: Fisun A.V., Kolokolov O.V., Bakulev A.L., Makarov N.S., Kravchenya S.S., Schabogina A.A., Popova O.V.
Organization: Saratov State Medical University
Summary:

The information about the cormorbid pathology in patients with skin and nervous systems diseases is summarized on the base of Russian and foreign scientific literature. The main attention is devoted to the combination of nervous system pathology with psoriasis and psoriatic arthritis. The high risk of cerebrovascular diseases development is pointed in psoriasis. Material concerning neuropathy caused by the cytostatics usage is represented in patients with psoriasis.

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Innovative medicines for treatment of psoriatic arthritis

Year: 2015, volume 11 Issue: №3 Pages: 423-425
Heading: Dermatovenerology Article type: Review
Authors: Levitan A.l., Reshetko O.V.
Organization: Saratov State Medical University
Summary:

The problem of effective treatment of psoriatic arthritis has not been solved yet. The search for new therapeutic options is very active in many directions. At the stage of clinical trials are drugs that block interleukin-17-a (secukinumab, ixekizumab, brodalumab), drugs that suppress interleukin-12 and interleukin-23 (ustekinumab). To modern means to ensure psoriatic arthritis include drugs that are inhibitors of small molecules orkinase pathways (apremilast, tofacitinib).

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Exrtraarticular manifestations of psoriatic arthritis in patients with low clinical and laboratory activity of disease

Year: 2011, volume 7 Issue: №1 Pages: 107-111
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Gaidukova I.Z., Kargalskaya O.G., Rebrov A.P.
Organization: Saratov State Medical University
Summary:

The research goal is to present the clinical observation that shows possibility of combination of low clinical and laboratory activity of psoriatic arthritis with 1) a large amount of exrtaarticular manifestations; 2) severe lesion of internal organs; 3) development of nephritis and hepatitis; 4) cardiovascular system pathology. The possibilities of different diagnostic and therapeutic methods have been considered in the article

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Peculiarities of dyslipidemia in patients with psoriatic arthritis: connection with atherosclerosis, cardiovascular risk factors and inflammation activity

Year: 2010, volume 6 Issue: №3 Pages: 592-596
Heading: Internal Diseases Article type: Original article
Authors: Rebrov A.P., Gaydukova I.Z.
Organization: Saratov State Medical University, Saratov Regional Clinical Hospital
Summary:

Objective: to found the dyslipidemia in patients with psoriatic arthritis and to study the connection between dyslipidemia and cardiovascular risk factors, atherosclerosis and inflammation activity. 40 persons with PsA without cardiovascular diseases were involved in the study, 25 healthy people were examined like controls. Activity of PsA was learned by DAS, Likert index, Ritchie Arthicular Index, Number of swelling joints (NSJ), ESR, C-reactive protein (CRP) and fibrinogen. Total cholesterol, triglycerides, low and high density lipoprotein cholesterol, hypertension, body mass index, individual cardiac history were performed like cardiovascular risk markers. The ultrasound measuring the thickness of intima-media layer (IML) in carotid arteries was performed to subclinical atherosclerosis study. Increase of total cholesterol, triglycerides and low density lipoprotein cholesterol level was found in patients with PsA comparative with controls. There was prevalence of high and moderate increase of total cholesterol in patients with PsA, and in controls only low increase was measured. Correlation between total cholesterol and NSJ, fibrinogen, hypertension and IML was found. Low density lipoproteins were tingly interrelated with ESR, hypertension and IML. Very low density lipoproteins were connected with age of disease beginning, hypertension and IML, and triglycerides-with hypertension, enthesitis and dactilitis. Dyslipidemia in patients with PsA characterizes by total cholesterol, triglycerides, low density lipoprotein cholesterol increase, but not high density lipoprotein decrease. There is the connection between dyslipidemia in PsA and inflammation activity, arterial hypertension and IML

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Endothelium Damage And Arterial Rigidity In Patients With Psoriatic Arthritis

Year: 2009, volume 5 Issue: №4 Pages: 544-548
Heading: Internal Diseases Article type: Original article
Authors: А.Р. Rebrov, I.Z. Gaydukova
Organization: Saratov State Medical University
Summary:

The research goal is to study the connection between activity of systemic inflammation, endothelium damage and arterial rigidity in patients with psoriatic arthritis (PsA). Expression of arterial damage (the level of circulation of endothe-liocytes (CEC)) and indices of arterial rigidity have been studied in 32 patients with PsA. Methods used in the investigation are oscillography, photopletismography and occlusion test. Control group consisted of 22 practically in good health state volunteers. Patients with PsA had endothelium dysfunction, damage of endothelium and higher arterial rigidity. These findings were related to PsA activity and observed in patients with serious joint damage

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