Saratov JOURNAL of Medical and Scientific Research

lipid peroxidation

Тhe efficiency of complex treatment of different variants of myasthenia gravis

Year: 2018, volume 14 Issue: №1 Pages: 145-148
Heading: Neurology Article type: Original article
Authors: Lapshina O.V., Antipenko Е.А., Gustov A.V.
Organization: Privolzhskiy Research Medical University

The aim: to evaluate the effect of complex restorative treatment on clinical manifestations and the state of oxidative homeostasis in patients with different variants of myasthenia gravis. Material and Methods. The analysis of indicators of biochemiluminescence, muscle strength according to the scales QMGS and MG-ADL, instrumental methods of research (ENMG and respiratory function) before and after treatment in 117 patients with myasthenia gravis is carried out. For comparative analysis of independent samples was used Mann — Whitney U-test, and for paired comparisons was used the Wilcoxon test. Results. The dynamics of oxidative homeostasis, clinical picture, indicators of instrumental methods of research (ENMG, respiratory function) in patients with myasthenia gravis, without thymoma and underwent thymectomy on the background of complex treatment with the use of antioxidant therapy is presented. In all studied groups against the background of complex treatment with application of antioxidant therapy increase in activity of antioxidant protection of organism and decrease in activity of free radical oxidation that correlates with clinical improvement in all groups of patients is noted. Conclusion. The use of antioxidant therapy in complex rehabilitation of patients with myasthenia gravis is pathogenetically justified, especially in patients without thymoma.

2018_01-1_145-148.pdf238.22 KB

The assessment of molecular markers of cell interaction and lipid peroxidation in rats with alloxan diabetes and trans- planted liver cancer after intravenous injection of gold nanorods

Year: 2015, volume 11 Issue: №2 Pages: 107-112
Heading: Biochemistry Article type: Original article
Authors: Bucharskaya А.В., Dikht N.I., Afanasyeva G.A., Terentyuk G.S., Zakharova N.B., Maslyakova G.N., Khlebtsov B.N., Khlebtsov N.G.
Organization: Institute of Biochemistry and Physiology of Plants and Microorganisms of Russian Academy of Sciences, Saratov State Medical University

Цель: оценить воздействие однократного внутривенного введения покрытых полиэтиленгликолем золотых наностержней на молекулярные маркеры межклеточного взаимодействия и показатели перекисного окисления в сыворотке крови четырех групп крыс: интактных, с аллоксановым диабетом, с перевитым раком печени; с перевитым раком печени на фоне аллоксанового диабета. Материалы и методы. Активность перекисного окисления липидов оценивалась по показателям гидроперекисей липидов, малонового диальдегида и молекул средней массы с использованием общепринятых спектрофотометрических методов, исследования молекулярных маркеров — фактора некроза опухоли TNF-a, инсулиноподобного фактора роста IGF-1, васкулоэн-дотелиального фактора роста VEGF-C проводились в сыворотке крови методом иммуноферментного анализа. Результаты. Выявлено, что при однократном внутривенном введении золотых наностержней не происходит значительного изменения количества маркеров межклеточного взаимодействия и показателей перекисного окисления липидов. в периферической крови. Заключение. Полученные результаты позволяют рекомендовать использование покрытых полиэтиленгликолем золотых наностержней в экспериментальной онкологии.

2015_02_107-112.pdf407.38 KB

Immune status and antioxidant protection changes in women with urogenital clamidiosis

Year: 2010, volume 6 Issue: №1 Pages: 111-113
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: F.K. Shebzukhova, T.P. Bondar
Organization: Stavropol State Medical University

The article presents the results of examination of 92 women with inflammatory process of urogenital system and the diagnosis of urogenital clamidiosis made for the first time. It points that the analysis of laboratory indices of both cellular and humoral immunity and antioxidant status of women with urogenital clamidiosis carried out before treatment has shown the active increase of relative ratio of T-cells and suppressor-cytotoxic T-cells and the decrease in their absolute values. The analysis has also revealed the increase of NO-cell subpopulation and concentration of immunoglobulin A and E, and activation of lipid peroxidation in the tendency of tocopherol acetase reduction that causes the significant decrease of body antioxidant protection

201001_111_113.pdf307.96 KB

Influence Of Pentoxifylline And Mexidol On Lipid Peroxidation And Anti-oxidant System In Patients With Urolithiasis

Year: 2009, volume 5 Issue: №4 Pages: 505-507
Heading: Clinical Pharmacology Article type: Short message
Authors: P.V. Glybochko, A.A. Svistunov, D.N. Khotko, A.N. Ponukalin, A.B. Polozov
Organization: Saratov State Medical University

Research objective is to prove correction possibility of lipid peroxidation and antioxidant system protection in neph-rolithiasis by taking pentoxifylline and mexidol. 158 patients with kidney concretion have been under the research. Distance shock-wave lithotripsy (ESWL) has been carried out. Structure of stones and antioxidant system state have been investigated in all patients. They have been divided into three groups - control, receiving pentoxifylline and receiving mexidol. Influence of indicated preparations on processes of lipid peroxidation and antioxidant system has been studied in case of different structure of concretion

200904_505_507.pdf260.93 KB