Saratov JOURNAL of Medical and Scientific Research

diagnostics

Characteristics of clinical findings and diagnostics of acute cerebral venous circulation disorder in immediate period following neurosurgical intervention for peripheral lung cancer metastasis into brain

Year: 2019, volume 15 Issue: №1 Pages: 67-71
Heading: Traumatology and Orthopedics Article type: Case report
Authors: Bazhanov S.P., Ulyanov V.Yu., Matveeva O.V., Tolkachev V.S., Shuvalov S.D.
Organization: Saratov State Medical University
Summary:

A rare case of cerebral venous circulation disorder in a female patient with peripheral cancer metastasis of the right lung upper lobe to the area of precentral and postcentral gyri of the left cerebrum hemisphere in the immediate post- surgical period is present. It has been shown that the diagnostics of impaired circulation throuth the superficial cerebral veins is rather complicated due to the lack of clinical symptoms specificity and poor sensitivity of neurovisualization methods.

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The methods of deep periprosthetic infection diagnostics in the area of knee joint

Year: 2018, volume 14 Issue: №3 Pages: 607-610
Heading: Traumatology and Orthopedics Article type: Review
Authors: Shpinyak S.P., Babushkina I.V., Maksyushina T.D., Galashina E.A., Chibrikova Yu.A., Bondarenko A.S., Norkin I.A.
Organization: Saratov State Medical University
Summary:

The data on the methods and promising areas of investigations potent to improve diagnostic tactics in patients with infectious complications after total knee replacement is presented.

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The capacity of the thrombin generation test in the diagnostics of hemostasis system disorders in patients with osteoarthritis

Year: 2018, volume 14 Issue: №3 Pages: 602-606
Heading: Traumatology and Orthopedics Article type: Original article
Authors: Shakhmartova S.G., Vorobyova I.S., Puchinyan D.M.
Organization:
Summary:

Aim: to determine the diagnostic significance of thrombin generation test parameters in the diagnostics of hemostatic disorders in patients with osteoarthritis of large joints in preoperative period. Material and Methods. 137 subjects have been investigated, among whom there were 115 hip and knee osteoarthritis patients, submitted for primary arthroplasty (68) and re-prosthetics (47); control group — 22 conventionally healthy blood donors. All subjects underwent plasma hemostasis study and thrombin generation test with two activators — RB (TF 2 pmol/ml) and RC-low (TF 5 pmol/ ml). Osteoarthritis patients were divided into two groups according to the results of thrombin generation test. The 1st group included patients with an adequate response to the stronger activator (t-lagR >t-lag ow, tt-peak^tt-peak^^), the 2nd —with an inversion response (t-lagRBlow). Results. In trie control group and group 1 patients, the thrombin formation process is more pronounced when using an activator with a high TF(RC-low) content than when using an activator with a lowTF (RB) content, which is regarded as an adequate reaction of thrombin formation to the action of a stronger agonist. Patients of the 2nd group inresponse to the action of the activator with a high content of TF was observed inhibition of the reaction of formation of thrombin, which was reflected in the slowdown in the speed of the generation of this enzyme and reduce its quantity. Conclusion. The use of two activators with different concentrations of tissue factor in the test of thrombin generation allows the nature of the response of the hemocoagulation system to initiate the process of thrombin formation to identify patients with adequate and inadequate response.

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Complex diagnostics and treatment potential of deep implant- associated infection of knee joint

Summary:

The review of open access literature on the issues of complex diagnostics and treatment potential of implant-associated infection of the knee joint area was given in the article. We describe clinical signs, the potential of laboratory diagnostics of deep implant-associated infection from the point of view of sensitivity and specificity as well as main methods of surgical treatment of the pathology.

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Pediatric flatfoot: etiopathogenesis and diagnostics

Year: 2018, volume 14 Issue: №3 Pages: 389-395
Heading: Traumatology and Orthopedics Article type: Review
Authors: Zatravkina T.Yu., Rubashkin S.A., Dokhov M.M.
Organization:
Summary:

Longitudinal flatfoot is heterogeneous group of conditions, characterized by a decrease of longitudinal arch height. In mobile flatfoot, this decrease is dynamic, it occurs under vertical load and proceeds asymptomatically. Specialists should pay attention to the "pathological" flatfoot developing with pain syndrome or causing severe gait disturbance. The review analyzes the fundamental and current opinions of local and foreign researchers on the development of flatfoot in children. Literatural data of age dynamics of foot development, epidemiology of flatfoot in childhood, the influence of flatfoot on the foot and gait biomechanics and basic diagnostic methods are presented.

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A rare case of Loeffler endocarditis associated with eosinophilic granuloma-tosis with polyangiitis

Year: 2017, volume 13 Issue: №4 Pages: 823-828
Heading: Internal Diseases Article type: Case report
Authors: Skryabina E.N., Safonova V.N., Agareva Т.А.
Organization: Saratov State Medical University
Summary:

Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare disease that affects small and medium-sized blood vessels of different organs, characterized by asthma, prominent peripheral blood eosinophilia. Cardiac involvement was reported in 20-50% and it is the major cause of mortality. A case of EGPA in a 43-year-old female, who had endocarditis, associated with thrombus formation in left ventricle, thromboembolic syndrome and recurrent stroke has been reported. The described case has showed that it is of crucial importance to perform the full cardiac imaging even in asymptomatic patients with suspected EGPA. The early identification of cardiac involvement may lead to better prognosis.

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Resonance radio wave diagnosis of localized sclerodermia: pilot study

Year: 2017, volume 13 Issue: №3 Pages: 585-590
Heading: Dermatovenerology Article type: Original article
Authors: Moiseev A.A., Utz SR.
Organization: Saratov State Medical University
Summary:

The purpose of the research was to study the diagnostic possibilities of the use of the active radiometry method for localized scleroderma (LS), both for monitoring the results of therapy, and for a comprehensive assessment of the functional state of body tissues in the study area, as well as the possibility of determining new foci of the disease. Material and Methods. In a pilot study, patients were presented with different forms of lesions and their different localization, as well as with different disease activity. The method of resonance wave diagnostics is implemented in the diagnostic complex "Aquafon". Results. The primary registration of wave activity in different types of foci may differ. The activity of the foci and the possibility of the appearance of new foci can be said not so much by the data of the initial measurements as by the integral data on their difference before and after the illumination procedure, which requires further study. Conclusion. It is necessary to improve the measurement technique, avoid places where the sensor is not well attached to the skin or minimize this effect. The research also aimed to conduct studies with simultaneous use of other methods.

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Clinical and morphological features of diagnosis and treatment of various forms of primary hyperparathyorosis

Year: 2017, volume 13 Issue: №3 Pages: 541-543
Heading: Surgery Article type: Original article
Authors: Kovalenko Yu.V., Tolstokorov A.S., Kravchenya A.R., Khubolov A.M., Manakhov G.A.
Organization: Scientific Research Institute of Traumatology Orthopedics and Neurosurgery of Saratov State Medical University n.a. V.I. Razumovsky
Summary:

Objective: optimization of the diagnostic algorithm and treatment methods for different clinical forms of the primary hyperparathyroidism. Material and Methods. The article presents the results of examination and operative treatment of 59 patients diagnosed with the primary hyperparathyroidism, such patients having symptoms specific for the disease or having no symptoms of the same. Results. We have not revealed intraoperative complications after surgical interference; laboratory findings have been normalized in 96.6% of cases. The patients having undergone the surgery have been followed up for 12 months with no relapse. 11.9% of the patients have been diagnosed with the asymptomatic primary hyperparathyroidism. Conclusions. Parathyroidectomy is the only radical and effective treatment for the primary hyperparathyroidism. Parathyroidectomy performed surgically to the proper extent, prevents the relapse as well as development of diseases resulting from the primary hyperparathyroidism.

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Revisiting of etiology, clinical picture and diagnosis of the Kleine-Levin syndrome.

Year: 2017, volume 13 Issue: №1 Pages: 181-187
Heading: Neurology Article type: Case report
Authors: Ulyanova О.V., Kutashov V.A.
Organization: Voronezh State Medical University n.a. N.N. Burdenko
Summary:

Objective: to draw the attention to the Kleine - Levin syndrome (SKL), a rare, poorly understood disease, not only in Russia but throughout the world. We analyzed the case of the 23-year old patient M, with the Kleine — Levin syndrome. SKL belongs to the group of recurrent hypersomnia and is characterized by long bouts of sleep lasting an average of 10-14 days, beginning with the imperative and difficulty awakening. During bouts of sleep observed unusual behavior of patients: hyperphagia; hypersexuality in males; irritability, restlessness, impaired mental activity; aggression; feeling of unreality of it all; confusion, hallucinatory episodes and depression in females. During wakefulness, marked dyspho-ria, emotional stupefaction, loss of memory. The syndrome develops in 4 times more often in men than in women, aged 12-25 years. Etiological factors: brain tumor, head trauma, metabolic disorders, acute infectious diseases with fever. Often the development of the syndrome is preceded by hyperemia and hypothalamic-pituitary dysfunction. The article discussed the etiology, diagnosis, and possible combinations of clinical manifestations in SKL.

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The modern view of the examination and treatment of patients with intracranial cystic formations

Year: 2017, volume 13 Issue: №1 Pages: 147-149
Heading: Neurology Article type: Author's opinion
Authors: Kolesov V.N., Lukina Е.М., Chekhonatsky А.А.
Organization: Saratov State Medical University
Summary:

Objective: to determine the diagnostic and treatment policy (conservative and operative) in patients with intracranial cysts of various origins. We observed 116 patients with different brain cystic formations. Diagnostic tactics and principles of treatment were refined. The evaluation of treatment results was made.

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