Saratov JOURNAL of Medical and Scientific Research

systemic lupus erythromatosis

Features of endothelial dysfunction changes at patients with systemic lupus erythematosus on a background of various therapy// Saratov Journal of Medical Scientific Research

Year: 2011, volume 7 Issue: №4 Pages: 822-827
Heading: Internal Diseases Article type: Original article
Authors: Nam I.F., Rebrov А.Р.
Organization: Saratov State Medical University, Saratov Regional Clinical Hospital

Aim. To investigated endothelial dysfunction in patients with systemic lupus erythematosus (SLE), depending on different activity, duration of disease and different type of therapy. Methods. We examined 77 patients with SLE during 1 year. We administered puls therapy with high dose glucocorticoids and cyclophosphamide in the 33 patients. 44 patients were given low dose steroids orally or hydroxychloroquine. We investigated the number of circulating endothelial cells in peripheral blood. Vasoactive function was assessed in reactive hyperemia test, antitrombogenic function with short-lived ischemia was examined. Results. Patients with SLE demonstrated endothelial damage, its antitrombogenic and vasodilatation function was reduced especially in high activity of disease. Pulse therapy improved endothelial function after 12-month treatment periods. The activity of the SLE decreased what was associated with reduced endothelial damage. Also vasodilatation function improved, but anticoagulant activity was without changes. Conclusion. It is necessary to administer pulse therapy according to the right indication despite potential danger of steroids and cyclophosphamide on endothelial function. Probably pulse therapy should be used with vasoprotective drugs in order to improve anticoagulant function

201104_822-827.pdf278.04 KB

Systemic Lupus Erythromatosis or Hiv Infection «Mask»?

Year: 2009, volume 5 Issue: №3 Pages: 444-446
Heading: Practice physician Article type: Short message
Authors: Е.Н. Скрябина, Н.А. Магдеева, И.Ф. Нам
Organization: Saratov State Medical University, Saratov Regional Clinical Hospital

The difficulties while conducting the differential diagnosis between systemic lupus erythromatosis (SLE) and HIV infection due to their clinical resemblance are reflected in this article

200903_444_446.pdf292.19 KB