Saratov JOURNAL of Medical and Scientific Research

Bashkir State Medical University of the Russian Health Care

Autonomous device for registration of direct current potential of eye in experiment and clinic

Year: 2018, volume 14 Issue: №4 Pages: 910-913
Heading: Ophtalmology Article type: Author's opinion
Authors: Mukhamadeev T.R., Yamgutdinov R.R., Vafiev A.S., Kalmetyev A.Kh., Yamlikhanov A.G., Tumashinov V.N.
Organization: Bashkir State Medical University of the Russian Health Care, ZAO Optimedservis
Summary:

 The article presents an autonomous device for recording of direct current potential of eye at rest and at different illumination levels to assess the functional state of the photoreceptor— retinal pigment epithelium complex in experiments on laboratory animals and in clinical practice including vitreoretinal surgery.

AttachmentSize
2018_4-2_910-913_1.pdf532.15 KB

Light-induced total electrical activity of retina in models of particular disorders in vivo and in vitro

Year: 2018, volume 14 Issue: №4 Pages: 903-909
Heading: Ophtalmology Article type: Original article
Authors: Mukhamadeev T.R., Ahmadeev R.R.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

Aim: to conduct an electrophysiological study of functional state of retina under the influence of ophthalmological surgical and typical pathogenic factors on various experimental models. Material and Methods. Experimental registration of electroretinogram (ERG) and total receptor potential (TRP) in vivo and in vitro under influence of various pathogenic factors. Results. It was shown that there is a slight decrease in the amplitude of the ERG in the early postoperative period after vitreoretinal surgery in rabbits followed by almost complete restoration of the electroretinogram to its original values. Registration of electrical activity of isolated retina of amphibians showed a rapid inhibition of a-, b- and d-waves of ERG during anoxia and their recovery during re-oxygenation. TRP inhibition during anoxia is developed more slowly than ERG inhibition, but its recovery does not occur during re-oxygenation. Preparations of isolated retinas with preserved pigment epithelium were much more resistant to oxygen deficiency. The results are discussed from a neurophysiological point of view and are consistent with the paradigm of retinal remodeling in experimental pathology with the leading role of neural mechanisms. Conclusion. The most adequate and effective methodological approach to assess the impact of typical and specific pathogenetic factors on the overall functional state of the retina is to register the total electrical activity of the retina in models in vivo. Studies of more subtle changes at the receptor, neuronal and interneuronal levels under the influence of various extreme factors on the retina are more expedient to carry out on in vitro models with registration of both total and local activity.

AttachmentSize
2018_4-2_903-909.pdf863.3 KB

Ретроспективный анализ биометрических характеристик и локализации увеальной меланомы по данным ультразвукового дуплексного сканирования орбиты

Year: 2018, volume 14 Issue: №4 Pages: 900-902
Heading: Ophtalmology Article type: Original article
Authors: Азнабаев Б.М., Александров А.А., Ишбулатова A.M.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

Цель: провести ретроспективный анализ биометрических характеристик и локализации увеальной меланомы по данным ультразвукового дуплексного сканирования орбиты. Материал и методы. В Центре лазерного восстановления зрения «Оптимед» г. Уфы за 2017-2018 гг. исследованы 22 пациента с объемным образованием сосудистой оболочки глаза — меланомой. Соотношение больных мужчин и женщин 1:1 (11 мужчин и 11 женщин). Возраст обследованных пациентов варьировался от 46 до 89 лет. Результаты. По данным проведенных ультразвуковых дуплексных сканирований орбиты чаще отмечалась парамакулярная локализация опухоли (72,2%). Высота проминенции объемных образований в среднем составила 7,6±4,6 мм, ширина основания 10,1±4,1 мм. У 20 пациентов (90,9%) определялся кровоток над объемным образованием. В 54,5% случаев наблюдалась вторичная отслойка сетчатки. Заключение. Ультразвуковое дуплексное сканирование орбиты является информативным неинвазивным инструментально-диагностическим методом, позволяющим выявлять увеальную меланому на ранней стадии.

AttachmentSize
2018_4-2_900-902.pdf515.7 KB

Bilateral acute generalized uveitis with Vogt-Koyanagi-Harada Syndrome

Year: 2018, volume 14 Issue: №4 Pages: 886-891
Heading: Ophtalmology Article type: Case report
Authors: Latypova Е.А.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

This study presents a case of bilateral generalized uveitis with exudative retinal detachment and Vogt- Koyanagi-Harada syndrome with a severe fulminant course in 27 year-old man with underlying neurological manifestations and hearing loss. The delayed diagnosis of the disease led to the rapid development of the late stage of uveitis with depigmentation of the fundus in the form of the "setting sun", persistent reduction of vision and complications with development of cataract, ophthalmic hypertension, epiretinal synechia and relapses. High-dose corticosteroids and immunosuppressive therapy allowed to achieve a positive effect and partially restore visual functions. Uveitis with a symmetrical lesion in both eyes is often an ophthalmological manifestation of systemic diseases. When it develops in individuals with darker skin pigmentation it is necessary to bear in mind the Vogt- Koyanagi-Harad syndrome.

AttachmentSize
2018_4-2_886-891.pdf2.28 MB

Aggressive posterior retinopathy of prematurity in a child conceived by in vitro fertilization

Year: 2018, volume 14 Issue: №4 Pages: 882-885
Heading: Ophtalmology Article type: Case report
Authors: Latypova E.A., Somova A.B., Matryuk D.I., Abdrakhmanova Yu.A.
Organization: Bashkir State Medical University of the Russian Health Care, «Republican Children's Clinical Hospital», Ufa
Summary:

Aggressive posterior retinopathy of prematurity (AP-ROP) is the most severe form ofretinopathy of prematurity (RP), characterized by early onset, fulminant course with absence of stagingand resistance to treatment. Today, the increase in AP-ROPincidence is associated with the changing standards for nursingof severely premature infants and wideprevalence of assisted reproductive technology — in vitro fertilization (IVF). The article presents a clinical case of aggressiveposterior retinopathy of prematurity in a girl with agestational ageof 25 weeks and a birth weightof about 860 grams who was conceived by IVF. Medical and high-tech laser treatment, fullycarried out in time, has lead toregression of this disease, which mayallowto preserve and develop visual function.

AttachmentSize
2018_4-2_882-885.pdf1.03 MB

Disruption of the microcirculation of the retinal macular zone in a patient who had hemorrhagic fever with renal syndrome according to OCT-angiography of the macula

Year: 2018, volume 14 Issue: №4 Pages: 880-882
Heading: Ophtalmology Article type: Case report
Authors: Aznabaev ВМ, Batyrshin RA, Aleksandrov АА, Idrisova LR, Khakimova NP.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

The article presents the results of a standard diagnostic examination and a description of the impaired microcirculation of the macular retinal area according to optical coherence tomography angiography (ОСТ angiography) in a patient who had hemorrhagic fever with renal syndrome. The survey revealed a violation of the microcirculation of the macula in the form of a decrease in perfusion of the inner layers of the retina. This diagnostic method allows objectively, quickly and without contact to assess the state of the microcirculation of the macula in persons who have had hemorrhagic fever with renal syndrome, and can be recommended for assessing the effects of the disease and preventing complications from the organ of vision.

AttachmentSize
2018_4-2_880-882.pdf1.14 MB

Results of treatment of optic neuritis

Year: 2018, volume 14 Issue: №4 Pages: 875-879
Heading: Ophtalmology Article type: Original article
Authors: Latypova Е.А.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

Purpose: to investigate the epidemiological and clinical features of optic neuritis, evaluate the effectiveness of treatment and underlying diseases. Material and Methods. 58 patients (60 eyes) with optic neuritis (ON) were observed. Among them, 54 adults (26 men, 28 women) aged 19-67 years (mean age 36±11.8 years) and 4 children (1 boy, 3 girls) 14-16 years. Along with the standard ophthalmologic examination, electrophysiological studies, visual evoked potentials and magnetic resonance imaging of the brain and orbit, and a consultation with a neurologist were conducted. The patients were divided into two groups. In the main group of 32 patients (34 eyes), the complex treatment is carried out according to the developed method, which includes daily administration of 1 % nicotinic acid solution in the age dose (from 1 ml to 6 ml per day) with pentoxifylline on the background of basic ON therapy. In the control group of 26 patients (26 eyes), along with basic therapy of 1% nicotinic acid, 1 ml intramuscularly is prescribed a course of 10-15 days. Results. The number of children of young working age (65.5%), including children (6.9%). In the overwhelming number of cases, intrabulbar neuritis was diagnosed (84.5%). In 8 of 9 patients, the precursor of retrobulbar neuritis (PN) was multiple sclerosis (MS). Among other etiological causes of ON viral infection prevailed (37.9%). In patients prolonged by the proposed method, an improvement in visual functions (increased visual acuity, expansion of the general boundaries of the visual field) was achieved in 91% of cases, including high vision (0.5-1.0) in 65% of cases; in patients of the control group, these indicators correspond to 54% and 23%. Conclusion. The use of nicotinic acid intravenously in age dosage with pentoxifyllone in complexes with basic therapy allows the use of methods of treatment of optical neuritis using etiology and can be recommended for widespread use in practical ophthalmology.

AttachmentSize
2018_4-2_875-879.pdf426.1 KB

Central retinal vein thrombosis in a patient with newly diagnosed congenital thrombophilia

Year: 2018, volume 14 Issue: №4 Pages: 872-875
Heading: Ophtalmology Article type: Case report
Authors: Latypova E.A., Zagidullina A.Sh., Yamlikhanov A.G., Arslanova A.l., Nugmanova A.R.
Organization: Bashkir State Medical University of the Russian Health Care, City clinical hospital 10 Ufa
Summary:

To date the etiology and pathogenesis of retinal vein thrombosis have not been fully studied despite a large body of scientific research. The article describes a rare clinical case of central retinal vein thrombosis in a 52-year-old man with newly diagnosed congenital thrombophilia.

AttachmentSize
2018_4-2_872-875.pdf1.17 MB

Intraoperative OCT-assisted vitreoretinal surgery

Year: 2018, volume 14 Issue: №4 Pages: 849-855
Heading: Ophtalmology Article type: Original article
Authors: Aznabaev В.М., Dibaev T.l., Husniyarova A.R.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

Purpose: comparative analysis of clinical and functional results of surgery of vitreomacular interface and rheg-matogenous retinal detachment with the use of intraoperative optical coherence tomography. Material and Methods. Clinical and morphofunctional data were analyzed in 102 patients with epiretinal fibrosis (ERF), idiopathic macular hole (IMH), and rhegmatogenous retinal detachment (RRD), who were divided into 2 groups. In the main group (n=52), the surgery was performed using intraoperative ОСТ control, in the control group without it. In the main group intraoperative control was performed at 4 stages of the surgery: before vitrectomy, after vitrectomy, during the main stage of the surgery and after completion of endotamponade of the vitreous cavity. During surgery for macular disorders intraoperative complications were assessed, in RRD the intraoperative screening for the detection of undiagnosed pathological changes was performed. In the postoperative period, clinical and functional results were assessed in up to 6 months. Results. The use of intraoperative ОСТ control allowed to reduce the frequency of intraoperative complications, such as capillary retinal bleeding (19.2% in the control group, 11.5% in the main group) and pinching of the inner retinal layers (not observed in the main group, in the control group its incidence was 23.1%) in macular surgery. Intraoperative ОСТ made it possible to better identify concomitant retinal pathology (secondary epiretinal membranes in the main group were found during the surgery in 11.5% of cases, in the control group in 4.2%, while in the postoperative period in 12.5%). In complicated cases of RDD, tomographic control allows to identify microstructural features of the posterior pole of the eye, which are important in achieving stability of the anatomical result, such as retinal defects over staphyloma of the posterior pole in high myopia cases. Conclusion. Intraoperative OCT-assisted vitreoretinal surgery reduces the rate of intraoperative complications during macular surgery and gives valuable diagnostic information in complicated retinal detachment cases.

AttachmentSize
2018_4-2_849-855.pdf1.73 MB

Clinical and functional results of surgical treatment of regmatogenous retinal detachment by ultrasonic vitrectomy 25G

Year: 2018, volume 14 Issue: №4 Pages: 841-845
Heading: Ophtalmology Article type: Original article
Authors: Aznabaev В.M., Dibaev T.I., Mukhamadeev T.R., Shatunova A.S.
Organization: Bashkir State Medical University of the Russian Health Care, ZAO Optimedservis
Summary:

Objective: to analyze clinical and functional outcomes of surgical treatment regmatogenic retinal detachment by ultrasound vitrectomy. Material and methods. Clinical and functional results of treatment of 70 patients (70 eyes) with regmatogenous retinal detachment (ROS) who received surgical care in the clinic OPTIMIZED from 2015 to 2018 In the main group (n=33) operations were performed by ultrasound vitrectomy 25G, in the control group (n=37) — by traditional guillotine pneumatic vitrectomy using the tools of the same caliber. During surgery, were analyzed: time of vitrectomy stage (sec), total duration of operation (min), achievement planned anatomical result (%). In the postoperative period (up to 12 months) analyzed: stability of anatomical result (%), maximum corrected visual acuity, intraocular pressure, morphometric criteria retinal conditions (OCT, OCT-angiography), incidence of complicated cataract (%). Results. Average value of vitrectomy stage time in the main group (378.3±125.2 sec) lower than in the control (490.9±175.5 sec), p<0.05. Total duration operations in both groups did not differ, but on average was somewhat shorter in the main group. group (53.6±9.4 and 64.2±23.5 min, respectively). Planned anatomical result in retinal adhesion in all sectors was achieved at the end of the operation in 100% of cases in both groups. No intraoperative complications were recorded in any of the cases. Ultrasonic vitrectomy permits the use of smaller values of the vacuum as on the stage initiation of posterior vitreous detachment (333.3±40.1 mm Hg).St) and at the stage of peripheral vitrectomy (203.2±51.5 mm Hg.art.) compared with traditional vitrectomy, where high vacuum was required: 600 mm Hg.art. at the stage of initiation of ZOST, 305,4±66,4 mm Hg.article on stage of peripheral vitrectomy. The anatomical result remained stable in all terms of the postoperative period in the main group in 100% of cases. In control group relapses of retinal detachment were registered in 8.1% of patients and successfully eliminated conducting an audit of the vitreous cavity. In the late postoperative period the most frequent complication was the development of complicated cataracts (27.1 % in the main group, 40.5% in the control). In both groups, by the 12th month of follow-up, high maximum corrected visual acuity (0.5 and higher in 66.6% of patients and in the main 47.3% of patients in the control group). Conclusion. Comparative study conducted the method of ultrasonic vitrectomy in the surgical treatment of rhegmatogenous detachment the retina has shown that this technique is an effective method that provides and stable anatomical and functional result.

AttachmentSize
2018_4-2_841-845.pdf263.35 KB