Saratov JOURNAL of Medical and Scientific Research

Bashkir State Medical University of the Russian Health Care

Combined operations for cicatricial entropion of the eyelids

Year: 2020, volume 16 Issue: №2 Pages: 633-635
Heading: Ophtalmology Article type: Original article
Authors: Nuraeva А.В., Galimova V.U.
Organization: Bashkir State Medical University of the Russian Health Care, Russian Eye and Plastic Surgery Center
Summary:

The purpose of the study is to evaluate the efficiency of combined operations with the use of allogeneic biomateri-als in patients with eyelids cicatricial entropion. Material and Methods. The group under study included 45 patients (50 eyes) aged from 5 to 71 years with cicatricial entropion and trichiasis of eyelids. The patients underwent reconstructive operations with the use of the allograft for eyelid plasty, allotendinous sututres and automucous membrane of lip. The efficiency of the performed operations was evaluated according to the following criteria: the position of the eyelid margin; the width of the palpebral fissure, the degree of the eyelids closure and presence of lacrimation. Results. In the early postoperative period (up to 14 days), all patients had correct position of the eyelids margin and narrowing of the palpebral fissure (up to 7-8 mm, absence of lagophthalmus. 9 patients still had lacrimation. In the long-term follow-up period (up to 3 years), we observed complete elimination of entropion, restoration of the palpebral tissue size and complete closure of eyelids in all patients. Conclusion. The use of the allogeneic biomaterials in the reconstruction of the eyelids with cicatricial entropion allows to eliminate eyelids deformation, lacrimation and lagophthalmus; to restore anatomical position and lost functions of the eyelid. The results of the study showed that it is possible to use the combined surgical intervention with simultaneous use of allogeneic grafts and automucous membrane of lip for complex cases of eyelids entropion.

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Morphological aspects of restoring a rat's eye socket defect with elastin-based biomaterial

Year: 2020, volume 16 Issue: №2 Pages: 614-618
Heading: Ophtalmology Article type: Original article
Authors: Lebedeva A.I., Nigmatullin R.T., Kutushev R.Z.
Organization: Bashkir State Medical University of the Russian Health Care, Russian Eye and Plastic Surgery Center
Summary:

The purpose of the study is to identify morphological aspects of replacement of xenogenic decellularized elastin matrix (DXEM) transplanted into a bone defect of the upper wall of the rat's eye socket. Materials and Methods. The experiment was performed on 60 Wistar rats, which produced a 7x4 mm defect in the upper edge of the orbit. DXEM was placed in the defect zone, in the experimental group (n=30). The size was similar to the defect and was fixed with a suture material-silk 50 microns. Soft tissues were sutured in layers in the control group (n=30). Tissue excision was performed after 1, 3 and 12 months. Histological, immunohistochemical and electron microscopic methods were used. Results. DXEM was gradually replaced by bone tissue against the background of a pronounced reaction of CD68+/MMP-9+ macrophages. This indicated its resorption and lysis. Osteogenesis occurred endesmally, periostally, which was preceded by centripetal migration of endothelial kidneys with subsequent differentiation into hemocapillaries and growth of loose fibrous connective tissue with progenitor cells. The microenvironment could contribute to differentiation of progenitor cells in the osteogenic direction and osteogenesis represented by reticulin fibers, TGFb, sulfated glycosaminoglycans in the control group, the defect remained open throughout the experiment. Conclusion. Decellularized biomaterial based on elastin matrix has osteoconductive and osteoinductive characteristics and can serve as an adequate biomimetic for bone defects restoration.

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Anatomical and biomechanical substantiation of the transplant for reconstructive surgery of the orbit bone walls

Year: 2020, volume 16 Issue: №2 Pages: 610-614
Heading: Ophtalmology Article type: Original article
Authors: Kutushev R.Z., Nigmatullin R.T., Musina L.A., Pervushin Yu.S., Gizatullina E.R.
Organization: Bashkir State Medical University of the Russian Health Care, Russian Eye and Plastic Surgery Center, Ufa State Aviation Technical University (USATU)
Summary:

The purpose is to study biomechanical parameters of elastin biomaterial's (BM) fibroarchitectonics. Material and Methods. For the study we usedxenogenic biomaterial made on the basis of the ligamentum nuchae (L. n.)) Bos taurus taurus, L. 1758. For histological examination of BM (n=24), we used electron microscopy (Jem-1011 microscope) and reflected light microscopy of histotopographic sections in the three planes, taking into account the orientation of elastic fibers (EF). Sections were stained with oreina, as well as according to Mallory and Van Gizon, they were impregnated according to Fut method. The mechanical properties of the material were studied on 11 samples with a size of 10x8x16 mm using a Zwick/Roell Z010 breaking machine, which allows for compression deformation. The strength of the suture fixation was determined by the tensile load (Pmax). To characterize the elastic properties of BM, the Young's modulus was calculated. Results. In the elastic deformation zone, the Young's modulus was 1.74±0.1 N/mm2. Subsequent loading of the BM led to deformations with stratification and formation of lamellar fragments. After removing the load, the BM restored its shape and size. BM fibroarchitectonics provides high strength of suture fixation. Conclusion. The BM fibroarchitectonics and the set of its structures form a single elastic-collagen complex. The results allowed us to develop structurally modified BM with osteoinductive properties.

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Cerebroprotective effects of xanthohumol on experimental stroke model: study design and preliminary results

Year: 2020, volume 16 Issue: №1 Pages: 377-379
Heading: Neurology Article type: Original article
Authors: Saitgareeva A.R., Akhmadeeva L.R.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

The aim of the study is to evaluate the neuroprotective effect of xanthohumol (XN) on experimental models of acute ischemic stroke in vivo and in vitro. Material and Methods. Middle cerebral artery occlusion (MCAO) and oxygen-glucose deprivation (OGD) are used as an in vivo and in vitro model. The object of the study is Sprag-Dawley rats, which are randomly divided into three groups: a control group; two groups operated by MCAO with and without XN. Primary culture of cortical neurons was obtained from newborn rats. We use the Bederson test and the angle test to evaluate neurological disorders. Results. Preliminary results indicate a possible cerebroprotective effect of XN in an ischemic stroke model. Conclusion. Prophylactic administration of xanthohumol before cerebral ischemia in an experiment can effectively reduce the volume of cerebral infarction and improve neurological deficiency 24 hours after MCAO

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Principles of the program of enhanced recovery of patients after radical prostatectomy

Year: 2019, volume 15 Issue: №2 Pages: 324-327
Heading: Urology Article type: Review
Authors: Pavlov V.N., Tarasenko A.I., Korelov Yu.A., Maksimova S.Yu., Khotko D.N., Khotko A.I.
Organization: Bashkir State Medical University of the Russian Health Care, I.M. Sechenov First Moscow State Medical University, Saratov State Medical University
Summary:

Analysis of statistical data on cancer incidence shows a high prevalence of such diseases as prostate cancer. The existing methods of treatment of this pathology are efective, but the question of reducing the surgical stress of patients who underwent surgery, reducing the number of complications, early mobilization and early recovery remains relevant. The presented literary review reveals the provisions proposed in the XX century, multimodal strategy «Fast track sur-gery», revealing the tactics of surgical patients throughout the perioperative period. The application of this protocol shows its efectiveness in reducing the duration of hospitalization and early rehabilitation of the considered group of patients.

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Principles of the program of enhanced recovery of patients after radical prostatectomy

Year: 2019, volume 15 Issue: №2 Pages: 324-327
Heading: Urology Article type: Review
Authors: Pavlov V.N., Tarasenko A.I., Korelov Yu.A., Maksimova S.Yu., Khotko D.N., Khotko A.I.
Organization: Bashkir State Medical University of the Russian Health Care, I.M. Sechenov First Moscow State Medical University, Saratov State Medical University
Summary:

Analysis of statistical data on cancer incidence shows a high prevalence of such diseases as prostate cancer. The existing methods of treatment of this pathology are efective, but the question of reducing the surgical stress of patients who underwent surgery, reducing the number of complications, early mobilization and early recovery remains relevant. The presented literary review reveals the provisions proposed in the XX century, multimodal strategy «Fast track sur-gery», revealing the tactics of surgical patients throughout the perioperative period. The application of this protocol shows its efectiveness in reducing the duration of hospitalization and early rehabilitation of the considered group of patients.

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Issues of epidemiology of epilepsy in the Republic of Bashkortostan

Year: 2019, volume 15 Issue: №1 Pages: 163-166
Heading: Neurology Article type: Original article
Authors: Novikova L.B., Akopyan А.Р., Sharapova K.M.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

Objective: to analyze the prevalence of epilepsy among adult population and the use of antiepileptic drugs (AED) in the Republic of Bashkortostan (RB) in 2013-2017. Material and Methods. Analysis of prevalence of etiological forms of epilepsy and used AEDs was carried out by analyzing data from annual reports of the neurological service of outpatient and inpatient medical institutions in cities and regions of the Republic of Bashkortostan, data of clinical examination of patients with a reliable diagnosis of epilepsy, as well as data from the Medical Information and Analytical Center (MIAC). Results. The prevalence of epilepsy in the Republic of Bashkortostan for the study period was 291.7- 325.8 case per 100 thousand population, which were most often recorded in central and eastern regions of the republic. The average age of patients ranged from 30.5±1.3to 41.8±0.2year. The ratio of men to women was approximately similar: 1.1:1.0. Cases of symptomatic epilepsy ranged from 82.6 to 46.5%. Among AEDs, carbamazepine was mainly used with a frequency of up to 47.4% and valproic acid with a frequency up to 32.9%. New generation drugs (parampanel) were rarely used (2.4%). Conclusion. The study of clinical and epidemiological characteristics of epilepsy is important for systemic organization of specific therapeutic and diagnostic measures and the creation of a specialized service to improve the quality of life of patients with epilepsy.

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Comorbidity of diseases of the cardiovascular system and primary open-angle glaucoma

Year: 2018, volume 14 Issue: №4 Pages: 949-953
Heading: Ophtalmology Article type: Review
Authors: Zagidullina A.Sh., Latypova Е.А., Nugmanova A.R.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

This literature review examines the potential diagnostic contribution of syndromes and cardiovascular diseases: hypertension, atherosclerosis, vascular dystonia, and cerebrovascular pathology in the development of primary open-angle glaucoma (POAG). The study of relationships is relevant due to the commonality of some pathogenetic factors of POAG and these diseases and syndromes. It is necessary to take into account the effect of comorbid pathology in the early diagnosis of POAG, which will improve its quality, and the correction of associated disorders will contribute to the effectiveness of complex treatment of the disease.

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Ocular rosacea: etiology, pathophysiological mechanisms, clinical manifestations and main methods of treatment

Year: 2018, volume 14 Issue: №4 Pages: 946-949
Heading: Ophtalmology Article type: Review
Authors: Mustafina G.R., Khismatullina Z.R., Sattarova R.R.
Organization: Bashkir State Medical University of the Russian Health Care, ZAO Optimedservis
Summary:

The review of the literature covers etiology, pathophysiological mechanisms, clinical manifestations and the main methods of treatment of ocular rosacea. Rosacea is one of the common chronic skin diseases with a diverse clinical picture. Ophthalmological manifestations of the disease are associated with affect to the cornea, conjunctiva and eyelids. The etiology and pathogenesis of the disease is not fully understood currently. Pathological processes in ocular rosacea are associated with disorders in vascular, immune and nervous systems, as well as with the influence of a number of microorganisms. In the treatment of ocular rosacea drugs of local and systemic action are used. Systemic therapy includes tetracycline and macrolide antibiotics and angioprotectors. Local therapy is associated with the use of artificial tears, anti-inflammatory drugs and local antibiotics. In severe cases of ocular rosacea surgical management is required.

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Physiotherapy in diseases of the anterior segment of the eye

Year: 2018, volume 14 Issue: №4 Pages: 941-945
Heading: Ophtalmology Article type: Review
Authors: Nazarova Е.М., Azamatova G.A., Akhtyamov A.E., Iseeva D.R.
Organization: Bashkir State Medical University of the Russian Health Care
Summary:

In the literature review were considered both well-established and modern physiotherapeutic methods used in the treatment of diseases of the anterior eye segment. Also, were presented the methods of combined effects of physical factors and pharmacological drugs, new methods of physiotherapy effects, were described the advantages and disadvantages, reinforcing the well-established recommendations of new modifications based on clinical trials.

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