Saratov JOURNAL of Medical and Scientific Research

parodontitis

Features of dental prosthetics at patients with chronic periodontitis and coronary heart disease

Year: 2019, volume 15 Issue: №2 Pages: 251-256
Heading: Stomatology Article type: Original article
Authors: Lepilin A.V., Eremin A.V., Lipatova T.E.
Organization: I.M. Sechenov First Moscow State Medical University, Saratov State Medical University
Summary:

Objective: at patients with chronic generalized periodontitis in combination with chronic ischemic heart disease to study the change of cytokines, biomarkers of osteoproliferation and osteoresorption in comparison with the character- istics of endothelial functions and the determine rational approaches to prosthetics. Material and Methods. 90 patients with periodontitis and coronary heart disease, who use metal, metal-ceramic and removable partial dentures using thermoplastic resin were survey. We studied of cytokines, markers of bone metabolism in the oral fuid, evaluated va-sodilating, vasoconstrictor and adhesive endothelial function. Results. The coronary heart disease in combination with chronic periodontitis is characterized by the endothelial dysfunction, which associated with the activity of periodontitis. Biochemical manifestations of periodontitis, bone resorption and endothelial dysfunction are more pronounced by the use patients metal dentures compared to metal-ceramic and removable partial dentures using thermoplastic resin. Conclusion. The use of patients at periodontitis and coronary heart disease metal dentures, in contrast to patients using metal-ceramic and removable partial dentures using thermoplastic resin, is accompanied the increase of biochemical markers of infammation and bone resorption in the oral fuid and the endothelial dysfunction.

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Features of dental prosthetics at patients with chronic periodontitis and coronary heart disease

Year: 2019, volume 15 Issue: №2 Pages: 251-256
Heading: Stomatology Article type: Original article
Authors: Lepilin A.V., Eremin A.V., Lipatova T.E.
Organization: I.M. Sechenov First Moscow State Medical University, Saratov State Medical University
Summary:

Objective: at patients with chronic generalized periodontitis in combination with chronic ischemic heart disease to study the change of cytokines, biomarkers of osteoproliferation and osteoresorption in comparison with the character- istics of endothelial functions and the determine rational approaches to prosthetics. Material and Methods. 90 patients with periodontitis and coronary heart disease, who use metal, metal-ceramic and removable partial dentures using thermoplastic resin were survey. We studied of cytokines, markers of bone metabolism in the oral fuid, evaluated va-sodilating, vasoconstrictor and adhesive endothelial function. Results. The coronary heart disease in combination with chronic periodontitis is characterized by the endothelial dysfunction, which associated with the activity of periodontitis. Biochemical manifestations of periodontitis, bone resorption and endothelial dysfunction are more pronounced by the use patients metal dentures compared to metal-ceramic and removable partial dentures using thermoplastic resin. Conclusion. The use of patients at periodontitis and coronary heart disease metal dentures, in contrast to patients using metal-ceramic and removable partial dentures using thermoplastic resin, is accompanied the increase of biochemical markers of infammation and bone resorption in the oral fuid and the endothelial dysfunction.

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Local effect of vitamin D on the immune system of periodontium

Year: 2019, volume 15 Issue: №1 Pages: 41-47
Heading: Stomatology Article type: Review
Authors: Ostrovskaya L.Yu., Zakharova N.B., Bodyleva А.Р., Bulkina N.V., Lysov A.V., Osipova U.L.
Organization: I.M. Sechenov First Moscow State Medical University, Saratov State Medical University
Summary:

 Literature review is devoted to the analysis of scientific findings about extraosseous effects of vitamin D on the immune system of the periodontal tissues. It was found that the biological functions of vitamin D (VD) in the body are diverse.Along with the detailed study of the effect on metabolic processes in bone tissue, VD makes a significant contribution to a large number of processes that ensure the activity of the immune system. In addition, VD increases the production of "endogenous antibiotics". This allows us to consider VD as a therapeutic agent that prevents the development of inflammatory and destructive changes in the periodontal tissues in population with simultaneous slowing of bone loss and preservation of bone mass of the dentofacial system. Currently detected hidden hypovitaminosis VD in almost majority of the population is considered a leading factor in the development of periodontal disease and its prevention and treatment is one of the most important tasks of therapeutic dentistry.

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Effect of vitamin D3 on the cytokine synthesizing activity of cells of gingival fluid

Year: 2016, volume 12 Issue: №3 Pages: 403-407
Heading: Stomatology Article type: Original article
Authors: Ostrovskaya L.Yu., Zakharova N.B., Mogila А.Р., Katkhanova L.S., Akulova E.V., Lysov A.V.
Organization: Saratov State Medical University
Summary:

Purpose: to study the effect of vitamin D3 on cytokine activity of macrophages and monocytes of gingival fluid. Material and methods. The examination and treatment of 42 patients with chronic generalized periodontitis at the age of 45-50 years were conducted. Gingival fluid was obtained from the periodontal pockets of patients. Material processed statistically. Results. Colecalciferol efficacy in inflammation and processes of destruction of periodontal tissue was twice higher than using traditional therapy. Resistance anti-inflammatory effect of the drug was maintained for 6 months, which had been confirmed by clinical and laboratory investigations. Conclusion. The use of applications of vitamin D in the treatment of periodontitis may achieve compensatory restoration of immune protection of the oral cavity.

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Treatment of chronic generalized periodontitis at women in the period of postmenopause

Year: 2015, volume 11 Issue: №1 Pages: 069-073
Heading: Stomatology Article type: Original article
Authors: Ostrovskaya L.U., Khanina A.l.
Organization: Saratov State Medical University
Summary:

Purpose: an assessment of efficiency of complex treatment of periodontitis at women in a period of postmenopause with the use of zoledronic acid. Material and methods. Examination and treatment of 90 patients with a chronic generalized periodontitis against post-menopausal osteoporosis has been conducted. Material is processed statistically. Results. Application of preparations of zoledronic acid in complex treatment of system osteoporosis and periodontitis allows to reduce the frequency of recurrence of periodontal disease and to improve indicators of bone remodeling. Conclusion. In conclusion it is worth while determining that zoledronic acid in complex therapy of periodontitis is an effective method of drug correction of a mineral exchange before periodontological surgery.

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Modern approaches to parodontitis therapy in HIV patients

Year: 2011, volume 7 Issue: №4 Pages: 910-912
Heading: Stomatology Article type: Original article
Authors: Oseeva А.О., Soboleva L.A., Bulkina N.V., Shuldyakov A.A.
Organization: Saratov State Medical University
Summary:

The research goal is to determine the clinical pathogenetic efficacy of Cycloferon liniment in the combined therapy of periodontitis in patients with subclinical stage of HIV-infection. Medical examination and treatment of 40 patients has been carried out. It is established that use of liniment Cycloferon in the combined treatment of patients with subclinical stage of HIV-infection allows to accelerate process of normalization of lipid peroxidation parameters and antioxidant potential of blood and to decrease infection (herpes symplex virus I, Candida albicans, staphylococcus aureus) in par-odontal recess and evidence of local inflammation. The considered method of therapy has been proved to improve convalescence period and to decrease frequency of parodontitis recurrences

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Investigation of violations of the functional activity of platelets in patients with chronic generalized periodontitis with a view to early diagnosis of periodontal pathology

Year: 2011, volume 7 Issue: №1 Pages: 295-297
Heading: Stomatology Article type: Short message
Authors: Kitaeva V.N., Bulkina N.V., Polosukhina E.N., Parfenova S.V., Kobzeva U.A.
Organization: Saratov State Medical University
Summary:

Violations occurring in the microcirculatory bed of periodontal tissue, are leading in the development of periodontal disease. The greatest changes are detected at the level of capillaries - lowering the tone and elasticity of blood vessels, reducing blood flow and the development of periodontal tissue hypoxia as a consequence -the development of the state of hypercoagulability and increased thrombotic events in the periodontal vessels

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Evaluating the effectiveness of the treatment of inflammatory periodontal disease on a background of chronic cholecystitis with the combined effect of the running of the alternating magnetic fields and low-intensity laser radiation

Year: 2011, volume 7 Issue: №1 Pages: 223-226
Heading: Stomatology Article type: Original article
Authors: Bulkina N.V., Kropotina A.J., Vulach N.A., Osipova J.L., Albitskaya J.N., Dyakova E.S.
Organization: Saratov State Medical University
Summary:

The aim of the study was to determine the characteristic clinical, instrumental and diagnostic criteria of inflammatory periodontal diseases on the background of chronic cholecystitis with subsequent evaluation of the effectiveness of therapeutic measures using the combined action of the running of an alternating magnetic field and low-intensity helium-neon laser. Application low-intensiti laser radiation and a running variable magnetic field in complex treatment of patients periodontitis with cholecystitis expressed anti-inflammatory action allows to stop quickly inflammatory process in periodontium and to reduce treatment terms

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Оptimization of periodontitis treatment in patients with chronic brucellosis infection

Year: 2010, volume 6 Issue: №2 Pages: 403-405
Heading: Stomatology Article type: Original article
Authors: L.A. Soboleva, R.R. Syakin, N.V. Bulkina, A.A. Shuldyakov
Organization: Saratov State Medical University
Summary:

For the purpose to determine the clinical pathogenetic efficacy of Cycloferon liniment in the combined therapy of parodontitis in patients with chronic brucellosis medical examination and treatment of 50 patients was carried out.
It was established that use of liniment Cycloferon in the combined treatment of patients with pariodontitis against chronic brucellosis allowed to accelerate process of normalization of parameters of lipid peroxidation and antioxidant potential of blood, to decrease infection load (herpes symplex virus I, candida albicans, staphylococcus aureus) in parodontal recess and evidence of local inflammation with reduction of activity of tumour necrosis and interleukin 1b, that provided acceleration of recovery processes, lowering in frequency of pariodontitis recurrences

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Clinical and pathogenetic approaches to development of parodontitis therapy in patients with chronic hepatitis С

Year: 2010, volume 6 Issue: №2 Pages: 322-325
Heading: Internal Diseases Article type: Original article
Authors: E.N. Blinnikova, L.A. Soboleva, N.V. Bulkina, A.A. Shuldyakov, A.N. Pospelov
Organization: Saratov State Medical University
Summary:

The research goal in to determine clinical and pathogenetic efficacy of Cycloferon liniment in the combined therapy of parodontitis in patients with chronic hepatitis C. Examination and treatment of 50 patients were conducted. It was revealed that the use of Cycloferon liniment in the combined treatment of patients with parodontitis accompanied by chronic hepatitis C allowed to accelerate process of normalization of lipid peroxidation and antioxidant potential of blood, to decrease infectious inflammation (herpes simplex virus I, candida albicans, staphylococcus aureus) in parodontal recess and local inflammation. The described method of treatment provided process of recovery and decrease in frequency of parodontitis recurrences

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