Saratov JOURNAL of Medical and Scientific Research

Veselova E.V.

Saratov State Medical University n.a. V. I. Razumovsky of the Ministry of Health of Russia, Department of Eye Disease, Assistant Professor, Candidate of Medical Science

Evaluation of the effectiveness of antiglaucomic operations with the use of the Ex-Press mini glaucoma shunt and Repegel-1 drainage in patients wi

Year: 2017, volume 13 Issue: №2 Pages: 394-400
Heading: Ophtalmology Article type: Original article
Authors: Kamenskikh T.G., Veselova E.V., Filatova V.S., Lyakhovich V.V., Golub' L.K., Karpenko A.A., Alekseyeva E.l., Kamenskikh I.D.
Organization: Saratov State Medical University
Summary:

The purpose of study is to evaluate the effectiveness of antiglaucomic operations with the use of the Ex-Press mini glaucoma shunt and Repegel-1 drainage in patients with primary open-angle glaucoma. Material and Methods. 65 patients (65 eyes) with an established diagnosis of uncompensated primary open-angle glaucoma of Stage III were observed. All patients underwent anti-glaucoma surgery. Patients of group 1 (15 patients, 15 eyes) underwent penetrating deep sclerectomy with implantation of the Ex-Press mini shunt under the scleral flap. Patients of group 2 (25 patients, 25 eyes) — penetrating deep sclerectomy with Repegel 1 drainage. Patients of group 3 (25 patients, 25 eyes) underwent sinus trabeculectomy without drainage. Results. In the early postoperative period, a good hypotensive effect was obtained in patients of all three groups. The most persistent antihypertensive effect was obtained in patients who underwent anti-glaucoma surgery with Repegel-1 drainage implantation. In patients who were implanted with the Ex-Press mini shunt, there was a significant decrease in the perimetrical MD index for 3 months. Conclusions. 1. Improvement of the photosensitivity of the retina in patients who underwent an antiglaucoma operation with Ex-Press shunt implantation, possibly due to the low invasiveness of the intervention and the absence of a sharp drop in IOP level. 2. Preliminary results (analysis 3 months after the operation) indicate a lower number of postoperative complications in the implantation of Repegel-1 drainage and a persistent hypotensive effect. 3. Patients who underwent antiglaucoma operations with implantation of drainage systems showed improvement of hemodynamic parameters in the pool of posterior short ciliary arteries in the postoperative period.

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Analysis of efficacy of travoprost with a preservative polyquad in the treatment of patients with primary open-angle glaucoma

Year: 2015, volume 11 Issue: №3 Pages: 337-341
Heading: Proceedings of all-Russia week of science with international participants Article type: Original article
Authors: Petrova Yu.V., Veselova E.V.
Organization: Saratov State Medical University
Summary:

The purpose was to evaluate the efficacy and tolerability of travoprost and timolol use in the treatment of patients with initial stage of primary open angle glaucoma (POAG), as well as a preservative effect on the state of the cornea. Material and Methods. We observed 30 patients with a diagnosis of POAG first revealed. Group 1 patients (24 eyes) afforded 0.004% solution travoprost, patients in Group 2 (16 eyes) — 0.5% solution of timolol maleate. Patients in Group 1 who received travoprost with ВАК were administered travoprost with preservative polyquad in the same mode instillation. After 3 months after changing medication patients underwent examination of the cornea by laser scanning confocal imaging. Results. Intraocular pressure (IOP) in patients in Group 1 dropped from 33±3mm Hg. Article 18±2mm Hg.Art. In group 2, IOP decreased from 32±2mm Hg. to 21 ±1,5 mm Hg. Art. After 3 months of treatment with travoprost polyquad total number of epithelial cells of the cornea increased to 6231 ±415 cells/ mm2, signs of edema were not detected in 18 of 24 eyes in 6 cases, swelling of the corneal epithelium decreased, decreased number of "bright" keratocytes, endothelial cells well visualized and of hexagonal shape. Conclusion. Application of travoprost in patients with POAG provides a marked hypotensive effect compared with timolol. Application of travoprost with polyquad improves the state of the front layers of the epithelium and the corneal stroma of patients with glaucoma, reduced patients complaints to sensation of a foreign body and eye discomfort and redness.

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Comparative analysis of the results of various physical therapy techniques in the treatment of patients with primary open-angle glaucoma with chronic cerebral ischemia

Year: 2012, volume 8 Issue: №2 Pages: 445-452
Heading: Neurology Article type: Original article
Authors: Kamenskih T.G., Raigorodskij Y.М., Veselova E.V., Mishkina E.J., Kolbenev I.O., Lazarev М.S., Kamenskih I.D.
Organization: Saratov State Medical University
Summary:

Aim of the study: to evaluate the effectiveness of the techniques of dynamic simultaneous transcranial magnetic therapy and resonance, and electrical stimulation, transcranial magnetic therapy and dynamic laser stimulation, magnetic simpatokorrektsii in the treatment of patients with primary open-angle glaucoma with chronic cerebral ischemia. Techniques. We observed 184 patients diagnosed with primary open-angle glaucoma who received different physical therapy techniques. Results. Patients treated with transcranial magnetic therapy and electrical stimulation or laser stimulation, in addition to improving visual function and improve the bioelectrical activity of the visual cortex, more pronounced than in other groups also observed the activation of the intraocular blood fow. Application of magnetic simpatokorrektsii allows for improvement of basic functional, electrophysiological and hemodynamic performance by reducing the activity of the sympathetic nervous system and reduce the vasopressor effect. Conclusion. Transcranial magnetic therapy in combination with electrical stimulation or laser stimulation is effective in the treatment of patients with POAG. In patients with primary open-angle glaucoma with chronic cerebral ischemia technique of magnetic sim-patokorrektsii compared with traditional methods of vasoactive therapy is more effective, which is manifested not only increase the visual functions, but also a decrease in cognitive impairment.

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Clinical-and-functional basing of the tactics of complex pharmacophysiothera-py of patients with primary glaucoma simplex

Year: 2010, volume 6 Issue: №1 Pages: 103-107
Heading: Ophtalmology Article type: Original article
Authors: T.G. Kamenskikh, I.O. Kolbenev, E.V. Veselova
Organization: Saratov State Medical University
Summary:

The research goal was to estimate the effectiveness of complex pharmacophysiotherapy of patients with initial glaucoma simplex on the basis of analysis of morphology, visual cortex electrobiological activity and regional blood flow level.
80 patients (149 eyes) aged 60-75 were examined. All of them had an initial glaucoma simplex of II or III stage and normalized intraocular pressure. Depending on the stage of glaucoma there were two groups of patients and each group contained two sub-groups. patients of sub-group A were treated by percutaneous electrostimulation with feedback based on visual evoked biopotentials; and patients of sub-group В were treated by traditional electrostimulation. All patients got complex eye examination before and after the therapeutic course, and in 3 months after it.
Method of selection of optimal electrostimulation parameters was worked out for the appropriate retina ganglionary cell effect. Individually selected electrostimulation in combination with nootropics contributes to eye hemodynamics improvement. Addition of magnetotherapy to the complex therapy of patients with eye hemodynamics leads to improvement of functional results. the increase of functional results of complex therapy with magnetotherapy that affects cervical sympathetic ganglia has been determined in patients with eye hemodynamics

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COMPLEX DIAGNOSTICS AND MONITORING OF PRIMARY GLAUCOMA SIMPLEX WITH USE OF COMPUTER COLORIMETRIC ANALYSIS AND DUPLEX DOPPLEROGRAPHY

Year: 2009, volume 5 Issue: №3 Pages: 363-366
Heading: Ophtalmology Article type: Original article
Authors: Yu.A. Dubinina, T.G. Kamenskikh, I.O. Kolbenev, E.V. Veselova
Organization: Saratov State Medical University
Summary:

Glaucoma simplex is one of the basic causes of blindness. The main problem of glaucoma is its early recognition. It's well known that changes of anatomic structure of each organ are preceded by functional disorders, including disturbances of hemodynamics. Method of computer colorimetric analysis of disk of optic nerve (DON) was worked out for the purpose of objective evaluation of its chroma as one of hemodynamics detection criteria. Computer program for analysis of DON chroma with calculation of integrated index (color index) was developed. DON chroma was analyzed in the group of persons suspected of glaucoma, in the group of patients with glaucoma simplex and in healthy people. This method along with confocal scanning tomography of DON allows to evaluate objectively in dynamics its state in the presence of glaucoma simplex. These methods are necessary to be used in complex for diagnostics of early stages of glaucoma simplex.

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