Saratov JOURNAL of Medical and Scientific Research

Ryabova A.Yu.

Saratov State Medical University n.a. V. I. Razumovsky Professor of Department of Therapy, Gastroenterol-ogy and Pulmonology Assistant Professor, DSc

Gender peculiarities of cardiovascular pathology in patients with chronic obstructive pulmonary disease

Year: 2019, volume 15 Issue: №1 Pages: 28-33
Heading: Internal Diseases Article type: Original article
Authors: Ryabova A.Yu., Kozlova I.V., Shapovalova T.G., Shashina M.M., Veselov V.V., Zemlyanskaya O.V.
Organization: Saratov State Medical University
Summary:

Purpuse: to research the gender-specific features of cardiovascular disease in the group of patients with chronic obstructive pulmonary disease (COPD). Material and Methods. We conducted a cross-sectional retrospective research of 419 patients hospitalized with exacerbation of COPD to the Pulmonology Department of Saratov Clinical Hospital №8 from 2015 to 2017 By the method of independent target sample, taking into account gender and multimorbidity 169 patients with COPD and cardiovascular disease were included into the research. Results. Relation between the nosological forms and the frequency of occurrence of cardiovascular pathology in the group of patients with COPD is gender- dependent. Gender features of heart remodeling in the group of patients with COPD and cardiovascular pathology are revealed. Women have more therapy adherence. Conclusion. The data that we obtained indicate the characteristics of the formation and course of the cardiovascular pathology in patients with COPD gender-dependent. Research of the features determines the optimal tactics of treatment, improves the prognosis and quality of life of co-morbid patients.

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Professor M.M. Kirillov (to the birth anniversary)

Year: 2018, volume 14 Issue: №1 Pages: 107-108
Heading: anniversary Article type: Short message
Authors: Shapovalova T.G., Ryabova A.Yu., Shashina M.M.
Organization: Saratov State Medical University
Summary:

The article is devoted to the 85th anniversary of the honored doctor of the Russian Federation, Professor M.M. Kirillov.

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Prediction of heart remodeling in patients with bronchial asthma

Year: 2018, volume 14 Issue: №1 Pages: 49-52
Heading: Internal Diseases Article type: Original article
Authors: Ryabova A.Yu., Shapovalova T.G., Shashina M.M., Lekareva L.I., Kudishina M.M.
Organization: Saratov State Medical University
Summary:

The aim of the study was to identify cardiac remodeling in bronchial asthma (BA), to construct a mathematical model for its prediction to optimize diagnosis. Material and Methods. Atotal of 283 patients with asthma who underwent a comprehensive examination including general clinical, immuno-enzymatic (determination of the N-terminal fraction of the brain natriuretic propeptide, activity of the angiotensin-converting enzyme) and instrumental methods: ECG, ECHO, daily Holter monitoring of ECG, FVD. Results. The analysis of the obtained results showed that in patients with asthma, structural, geometric changes of the myocardium of the right and left ventricles were noted, increasing as the disease became more severe. The activation of local neurohormonal systems, primarily myocardial is no less important. An analysis of the relationship between the concentration of natriuretic peptide and the end-diastolic size of the right ventricle in BA patients revealed a moderate correlation relationship. There was a weak correlation between the right ventricular end-diastolic size, the right ventricular frontal wall thickness and the ACE level. The analysis of the relationship between the above dimensions of the right ventricle and the index of the balance of the autonomic nervous system was reliable. Conclusion. Thus, the development of cardiac remodeling in AD patients occurs against the background of the hyperactivation of neurohumoral systems, including sympathoadrenal, renin-angiotensin-aldosterone and the system of natriuretic peptides.

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Pulmonary lymphangioleiomyomatosis (case report)

Year: 2017, volume 13 Issue: №4 Pages: 828-833
Heading: Internal Diseases Article type: Case report
Authors: Shashina M.M., Shapovalova T.G., Kazimirova N.E., Ryabova A.Y., Arkhangelskaya Е.Е., Lifanova D.V., Chernyshkova M.A.
Organization: Saratov State Medical University, Saratov Clinical Hospital № 8
Summary:

This article presents a clinical observation of a patient with a proven diffuse-nodular form of lymphangioleiomyomatosis of the lungs. Features of the course of the process against the background of pathogenetic therapy which included sirolimus and progesterone have been considered. It is necessary to raise awareness of doctors about the disease that facilitates timely diagnosis and treatment.

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Hemodynamics features and contractive miocardial function in patients with chronical obstructive pulmоnаry diseases accompanied by bronchial asthma

Year: 2010, volume 6 Issue: №1 Pages: 084-088
Heading: Internal Diseases Article type: Original article
Authors: T.G. Shapovalova, M.V. Volkova, N.V. Shelobanova, A.Yu. Ryabova, L.I. Lekareva
Organization: Saratov State Medical University
Summary:

Hemodynamics and contractive myocardial function features in patients with chronic obstructive pulmonary disease (OOPD) accompanied by bronchial asthma have been examined. The changes of cardiohemodynamics have been presented according to the ventilation disorders level, balance of blood cytokines (IL-4, IL-6, IL-8, TFN-a) and adhesion molecules level (IOAM-1, VOAM-1)

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Features of The Heart Remodeling in Patients with Chronic Obstructive Pulmonary Diseases, Combined with Coronary Heart Diseases

Year: 2009, volume 5 Issue: №3 Pages: 352-355
Heading: Internal Diseases Article type: Original article
Authors: T.G. Shapovalova, N.V.Shelobanova, M.V. Volkova, A.Yu. Ryabova, L.I. Lekareva
Organization: Saratov State Medical University
Summary:

The characteristics of heart remodeling in patients with chronic obstructive pulmonary diseases ( COPD), associated with coronary heart diseases (CHD) were examined. The changes of structural and functional state of myocardium, intracardiac relationships with associated pathology were under study. The role of blood inflammatory cytokines (IL-6, IL-8, TNF-a) and the level of cell adhesion molecules (ICAM-1, VCAM-1) in exacerbating myocardial dysfunction was clarified.

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