Saratov JOURNAL of Medical and Scientific Research

Zryachkin N.I.

Saratov State Medical University n. a. V. I. Razumovsky, Head of Department of Pediatrics of the Institute of Professional Training of Higher Qualifcations and Additional Professional Education, Professor, DSc

Eradication therapy in children: the choice of the optimal treatment regimen

Year: 2019, volume 15 Issue: №2 Pages: 225-231
Heading: Pediatrics Article type: Review
Authors: Zryachkin N.I., Ananyeva O.V.
Organization: Saratov State Medical University
Summary:

The review is devoted to the choice of the optimal treatment regimen of eradication therapy in children. Main tasks in the treatment of children with gastroduodenal pathology associated with Helicobacter pylori are eradication of the pathogen, restoration of the damaged mucosa and prevention of recurrence of the infection. A particular importance in the composition of eradication schemes is the choice of antibacterial drugs. The main requirements for anti-Helico-bacter therapy regimens used in pediatric practice are: eradication rate of at least 80 %, economic accessibility, good tolerability with minimal severity of adverse reactions, optimal frequency of admission. An analysis of a number of domestic and foreign studies has shown that insufcient adherence of the patient to therapy, the presence of antibacterial resistance, pathogenicity factors in a number of strains of H. pylori have a negative efect on the efectiveness of treatment and should also be taken into account when choosing therapeutic tactics. Successful eradication of H. pylori in most cases depends on the optimal treatment regimen also has an impact on the result.

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Issues on health status and rehabilitation of young children born with extremely low and very low weight

Year: 2017, volume 13 Issue: №2 Pages: 245-251
Heading: Pediatrics Article type: Review
Authors: Scherbatyuk E.S., Khmilevskaya S.A., Zryachkin N.I.
Organization: Saratov State Medical University
Summary:

The review presents literature data on the catamnesis of children born with extremely low and very low weight, identification of the most common pathological conditions, of the incidence rate and the main causes of disability in childhood, the rationale for the need for early initiation of rehabilitation actions aimed at preventing and correction of these conditions. The article highlights difficulties in assessment of physical and neuropsychological development of deeply premature babies, related to the heterogeneity of contingent of the children being surveyed and the difference in the tests used to determine these parameters. It was noted that for a comprehensive assessment of their health they also need to determine quality of life using the developed scales. The author substantiated the need to improve the system of medical support for such children at all phases of nursing and rehabilitation process and perforce to introduce a personal approach with differentiated programs of medical examination and rehabilitation in the wide practice.

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Efficiency of various preventive methods of perinatal mother and child complications

Year: 2012, volume 8 Issue: №1 Pages: 043-047
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Sadretdinova T.L., Vasilenko L.V., Zryachkin N.I.
Organization: Saratov State Medical University
Summary:

Purpose: to study efficiency of various methods of prevention of perinatal complications in mother and child. Material and methods. In three risk groups preventive treatment of intrauterine infected fetus (IUIF), gestosis, noncarrying of pregnancy and fetoplacental insufficiency has been carried out. In group I consisted of 71 pregnant women preventive treatment has included medication with application of antioxidants; stimulators of processes of carboxylation in cycle Krebs; endogenic synthesis prostaglandins, prostacyclin; drugs improving processes of microcirculation, stabilizing function of endothelium ofvessels, an exchange of homocysteine. In group II consisted of 67 pregnant women prevention of IUIF and complications has been carried out by means of physical exercises in combination with aqua aerobics. In group III consisted of 100 women prevention of IUIF has been standard. In the control group IV consisted of 70 women pregnancy has not been complicated. Parameters of oxidant and antioxidant systems, central hemodynamics, determined in this group have been determined as normal for comparison. Results. In relation to group III medicamen-tous treatment in group I, regular aqua aerobics in group II have allowed to lower frequency of IUIF, perinatal mother complications, perinatal diseases, death rates in newborns and morbidity in children of early age. Conclusion. For the prevention of IUIF, mother and child perinatal complications, morbidity in children of early age it has been proposed to use medication and regular aqua aerobics which provides nonmedicamentous pregnancy course

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Leading factors of cerebral ischemia in newborns

Year: 2010, volume 6 Issue: №4 Pages: 772-774
Heading: Obstetrics and Gynecology Article type: Original article
Authors: Yakovleva O.V., Muzurova L.V., Zryachkin N.I.
Organization: Saratov State Medical University
Summary:

The research goal is to study the causes of perinatal hypoxic impairments of Central Nervous System (CNS) in fetus and newborn. Risk factors of cerebral ischemia development in fetus and newborn are likely to be found anemia, chronic adnexitis in mothers, threatened abortions, athletic type of pregnant women, loop of cord during the pregnancy course, rapid parturition and acute respiratory diseases during the II and III trimesters of pregnancy

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Course Of Pregnancy, Delivery And Health State Of Newborns After Preventive Treatment Of Gestosis In Pregnant Women Of Risk Group

Year: 2009, volume 5 Issue: №4 Pages: 533-536
Heading: Obstetrics and Gynecology Article type: Original article
Authors: O.S. Odnokozova,L.V. Vasilenko ,N.I. Zryachkin
Organization: Saratov State Medical University
Summary:

The research objective is to decrease the frequency of perinatal complications in mother, fetus and newborn. Methodology used is prospective study. Course of pregnancy, delivery, postnatal period and neonatal period has been studied at 50 women and children (the basic group), at 80 women and children (group of comparison). The state of mi-crocirculation was studied at the I- II trimesters of pregnancy before and after treatment by means of biomicroscopy of vessels of eye conjunctiva by slit lamp with computer data processing. Homocysteine was studied at the I- II trimesters of pregnancy before and after treatment, and children of The control group consisted of 63 pregnant women without complicated anamnesis and with somatic status who gave birth to 63 children. At the I trimester of pregnancy in risk groups of development of gestosis hyperhomocysteinemia, preclinical disturbances of processes of microcirculation were observed. The method of preventive treatment of gestosis in the basic group included anticoagulant - Vessl Due F, vitamin E, essenciale H, folic acid, vitamin B6, vitamin B12. The preventive treatment was directed on stabilization of function of vessel endothelium, improvement of processes of microcirculation leading to decrease in frequency and severity of gestosis, perinatal complications in mother and newborn

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DYNAMICS OF CYTOKINE ACTIVITY IN PATIENTS’ BLOOD SERUM

Year: 2008, volume 4 Issue: №4 Pages: 56-58
Heading: Clinical Laboratory Diagnostics Article type: Original article
Authors: Z.S. Topchieva, G.P. Gladilin, N.I. Zryachkin
Organization: Tambov City Hospital №4, Saratov State Medical University
Summary:

In this work dynamics ofinflammatoryandanti-inflammatory cytokines in blood serum of 65 patients with atrophic arthritis depending on activity, duration of inflammatory process, presence or absence of the rheumatoid factor is represented.
It is determined: that the level ofФНО-а in blood serum among patients with atrophic arthritis does not depend upon the growth of an inflammatory process’s activity and presence or absence of the rheumatoid factor, but it depends upon the clinical course’s duration. The maintenance of ИФ-у and ИЛ-4 in patients' blood serum with atrophic arthritis depends upon a degree of an inflammatory process’s activity and does not depend upon the clinical course’s duration and presence or absence of the rheumatoid factor.

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