Saratov JOURNAL of Medical and Scientific Research

endothelin-1

Comparative analysis of the content of biochemical markers of endothelial dysfunction in women with preeclampsia and in the development of vascular retinal pathology

Year: 2020, volume 16 Issue: №2 Pages: 668-671
Heading: Ophtalmology Article type: Original article
Authors: Fil А.А., Sorokin E.L., Kolenko O.V.
Organization: Far Eastern Federal University, Postgraduate Institute for Public Health Workers, S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

Purpose: to study the level of markers of endothelial dysfunction (ED) in women with preeclampsia and with the development of retinal vein occlusions. Material and Methods. The main group was formed by 62 pregnant women with preeclampsia (124 eyes). Their age ranged from 22 to 43 years (30±6.9 years). The 1st comparison group was formed by 20 women with a physiological course of pregnancy, a comparable age and duration of pregnancy. The 2nd comparison group included 16 non-pregnant women with occlusions of the superior temporal branches of the central retinal vein (16 eyes). As a control group, 20 somatically healthy, non-pregnant women (40 eyes) were selected. Markers of ED were studied twice in the main and 1st comparison groups (III trimester of pregnancy and 6-8 months after delivery). In the control and 2nd comparison groups — once. Results. The levels of von Willebrand factor and endothe-lin-1, which are known to be the main markers of ED development, turned out to be high in women of the main group (109.3±33.2% and 2.69±1.49 ng/ml respectively), and in the 2nd comparison group (110.3±29.2% and 2.6±0.4 ng/ml respectively). Conclusion. Increased endothelin-1 in the tear fluid and von Willebrand factor in blood plasma in women with preeclampsia, as well as maintaining their high levels after 6-8 months, after childbirth may indicate the presence of generalized ED, which is a favorable background for the development of vascular retinal pathology in the remote postpartum period.

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