Saratov JOURNAL of Medical and Scientific Research

Sosnovskii S.V.

S. Fyodorov Eye Microsurgery Federal State Institution, St. Petersburg branch, Oph-thalmologist of Department of Vitreoretinal Surgery, Associate Professor, PhD

Pedicled retinal pigment epithelium — choroid graft autotranslocation in scarred age-related macular degeneration

Summary:

The purpose of the study is to analyse the effectiveness of pedicled RPE (retinal pigment epithelium) — choroid graft autotranslocation in scarred neovascular age-related macular degeneration (AMD) treatment. Material and Methods. Pedicled RPE — choroid graft autotranslocation was performed on 8 patients with scarred wet AMD. Follow-up was from 6 to 30 months. Visual acuity, ophthalmoscopy, optical coherent tomography and indocian-green angiography were analysed. Results. The average visual acuity increased from 0.009±0.006 to 0.018±0.022 (p=0.15). Visual acuity increased in 50% of the patients. In 50% of patients visual acuity decreased, which was associated with proliferative vitreoretinopathy in post-op period with retinal detachment formation. No cases of choroidal neovascularization recurrence were detected. According to angiography data normal choroidal perfusion in the rotated RPE — choroid patch was revealed after 1 month during the follow-up examination. Conclusion. Pedicled RPE — choroid graft translocation can be successively performed in case of scarred neovascular age-related macular degeneration.

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The vitreoretinal interface pathology and anti-VEGF therapy of macular edema in diabetic angioretinopathy

Year: 2020, volume 16 Issue: №2 Pages: 635-638
Heading: Ophtalmology Article type: Original article
Authors: Oskanov D.H., Sosnovskii S.V., Boiko E.V.
Organization: S. Fyodorov Eye Microsurgery Federal State Institution
Summary:

The purpose of the study is to assess the effect of vitreoretinal interface changes in patients with diabetic macular edema as far as the effectiveness of anti-VEGF therapy is concerned. Material and Methods. The study included 198 patients (198 eyes) with diabetic macular edema (DME). Two groups were formed: group 1 — patients without pathological changes in vitreoretinal interface (VRI); group 2 — patients with pathological changes in VRI. We studied the best-corrected visual acuity according to the Snellen table, central retinal thickness and VRI condition according to optical coherence tomography before the intravitreal administration and 1 month after. Results. Significant differences in best-corrected visual acuity were observed before and 1 month after intravitreal administration in both groups (p<0.05). A significant decrease in central retinal thickness in both groups was revealed (p<0.001). A statistically significantly larger average decrease in the thickness of the central retinal in group 1 was obtained (p<0.001). Conclusion. Improvement in visual acuity is significant in anti-VEGF therapy of DME with normal VRI, while with the pathological VRI it is not significant. The degree of improvement in average visual acuity and the degree of decrease in the average thickness of the central retina during anti-VEGF therapy of DME is significantly lower in the presence of VRI pathology. Presence of the vitreoretinal interface pathology reduces the effectiveness of antiangiogenic therapy of DME.

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