Saratov JOURNAL of Medical and Scientific Research

matrix metalloproteinase 9

Clinical and immunological evaluation of pathological changes in the organ of vision in patients with open-angle glaucoma

Year: 2020, volume 16 Issue: №1 Pages: 237-241
Heading: Ophtalmology Article type: Original article
Authors: Malysheva Ju.V., Volkova N.V., Kursakova Ju.V.
Organization: Irkutsk State Medical Academy of Postgraduate Education, Irkutsk State Medical University, S. Fyodorov Eye Microsurgery Federal State Institution

The purpose is to perform clinical assessment of neurodegenerative and inflammatory changes in the visual organ in patients with advanced open-angle glaucoma and to identify the relationship between the degree of neurodegenerative and inflammatory changes. Material and Methods. Prospective examination of 26 patients with advanced open-angle glaucoma and 22 patients without changes in eye hydrodynamics with determination of TGF-p and MMR-9 concentrations in lacrimal and anterior chamber aqueous humor. Results. There was a statistically significant decrease in the concentration of MMR-9 in patients with glaucoma by 1.62 times in the lacrimal fluid (p<0.01) and by 2.17 times in the anterior chamber aqueous humor (p<0.05) in comparison with the control group. There was a statistically significant inverse relationship between MMP-9 in the lacrimal and the indicator characterizing a clinical picture of inflammatory reaction of the conjunctiva (p=0.02) and direct interdependence of the concentration of MMP-9 in the lacrimal and the thickness of the nerve fiber layer (p=0.02). Conclusion. The study revealed correlations between the degree of severity of the conjunctival inflammatory response, neurodegenerative changes, and the content of MMR-9 in the lacrimal and aqueous humor of the anterior chamber of patients with open-angle glaucoma.

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