Saratov JOURNAL of Medical and Scientific Research


The role of mTOR in reprogramming of tumor associated macrophages and in cancero-genesis (review)

Year: 2020, volume 16 Issue: №1 Pages: 115-121
Heading: Рathophysiology Article type: Review
Authors: Martynova T.N., Malyshev I.Yu.
Organization: A. I. Yevdokimov Moscow State University of Medicine and Dentistry, Institute of General Pathology and Pathophysiology

Macrophages are heterogeneous population of cells, which differentiate into distinct functional groups depending of the external signals. Agonists of toll-like receptors (TLRs) and cytokines bind to corresponding receptors and cause changes in the metabolism and expression of genes in myeloid cells located in the innate immune system. These changes in phagocytes are occurring during their activation. As a result, they become polarized, acquiring a determined phenotype. This gene expression changes realize in the tumor microenvironment. mTOR — serine/threonine protein kinase, which receives various signals from cell environment. It causes changes in protein biosynthesis and cell metabolism. mTOR takes part in the activation of macrophages influenced by cytokines or agonists of TLRs. It determines the role of kinase in reprogramming mechanisms and in the regulation of cytokines production according to the type of received signals respectively. The review has been made about the role of mTOR in macrophages' reprogramming, in particular tumor-associated ones. The PubMed resource is used for information search

2020_01_115-121.pdf602.97 KB

Diagnosis of retinocytoma in the eye with swelling mature cataract (clinical case)

Year: 2020, volume 16 Issue: №1 Pages: 31-33
Heading: Ophtalmology Article type: Case report
Authors: Krasyuk E.Yu., Ovchinnikov V.I.
Organization: Tambov Ophthalmological Clinical Hospital

A clinical case of a rare retinocytoma tumor in a patient with swelling cataract and phacomorphic glaucoma is presented. A comprehensive examination of the patient using various diagnostic methods allowed to make the correct diagnosis and conduct timely surgical treatment with predictable results.

2020_01_031-033.pdf593.9 KB